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MSH3

  • Official Full Name

    mutS homolog 3

  • Overview

    The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNA mismatch repair system. MutS beta initiates mismatch repair by binding to a mismatch and then forming a complex with MutL alpha heterodimer. This gene contains a polymorphic 9 bp tandem repeat sequence in the first exon. The repeat is present 6 times in the reference genome sequence and 3-7 repeats have been reported. Defects in this gene are a cause of susceptibility to endometrial cancer. [provided by RefSeq, Mar 2011]
  • Synonyms

    MSH3; mutS homolog 3; DUP; MRP1; DNA mismatch repair protein Msh3; hMSH3; mismatch repair protein 1; divergent upstream protein;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MSH3-494H Recombinant Human MSH3 Protein, His-tagged E.coli His
Human MSH3-23HCL Recombinant Human MSH3 HEK293T cell lysate HEK293 Myc/DDK
Zebrafish MSH3-6056Z Recombinant Zebrafish MSH3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MSH3 Related Articles
  • MSH3 Related Research Area

MSH3 involved in several pathways and played different roles in them. We selected most pathways MSH3 participated on our site, such as Mismatch repair, Pathways in cancer, Colorectal cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with MSH3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Mismatch repairMLH3;RFC4;RFC2;RFC1;RPA4;PMS2;RFC3;LIG1;SSBP1
Pathways in cancerWNT5A;FZD3;IKBKB;RHOA;NKX3;FGFR2;RUNX1;FGF13;PLCB1
Colorectal cancerMSH2;TCF7;MAPK10;BCL2;RHOA;CYCS;PIK3R5;KRAS;APPL1

MSH3 has several biochemical functions, for example, ATP binding, DNA-dependent ATPase activity, Y-form DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MSH3 itself. We selected most functions MSH3 had, and list some proteins which have the same functions with MSH3. You can find most of the proteins on our site.

Function Related Protein
ATP bindingDCKL1B;DDX28;NLRC5;ATP2A2B;DYNC1LI2;OASL2;BMPR2A;NEK7;PKN2
DNA-dependent ATPase activityDHX36;TTF2;MSH6;TOP2A;RAD51C;MSH2;ERCC6;SMARCAL1;CHD8
Y-form DNA bindingMEN1;MSH3;WRN;MSH2;RAD18
centromeric DNA bindingMLH3;CENPB;MSH2;CENPC1;MSH3;ZW10;KIF2C
contributes_to dinucleotide insertion or deletion bindingMSH2;MSH3
contributes_to dinucleotide repeat insertion bindingMSH3;MSH2
double-strand/single-strand DNA junction bindingMSH3;MSH2
enzyme bindingCAD;UGT1A6A;HINFP;CYP2A6;TBP;ERN1;AKT1;CYP3A4;TSPAN15
NOT guanine/thymine mispair binding
heteroduplex DNA loop bindingMSH3;MSH2
contributes_to mismatched DNA bindingMSH6;MSH2;MSH3
NOT contributes_to oxidized purine DNA binding
protein bindingMRPS9;HMGCR;GSDMD;PTPN1;CDT1;STARD3;UIMC1;CRYAB;TUBB2A
NOT protein homodimerization activityMECOM;MLXIPL;MYO9B;NUDT16L1;EXT2;DDIT3;MSH6;MSH3;KCNA3
contributes_to single guanine insertion bindingMSH3;MSH6;MSH2
contributes_to single-stranded DNA bindingIGHM;POLR2D;MLH1;MSH3;IGJ;MSH2;PMS2

MSH3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MSH3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MSH3.

PCNA; MLH1; MSH2; RCHY1; ssdna_dn

Muro, Y; Nakashima, R; et al. Autoantibodies to DNA Mismatch Repair Enzymes in Polymyositis/Dermatomyositis and Other Autoimmune Diseases: A Possible Marker of Favorable Prognosis. ARTHRITIS & RHEUMATOLOGY 66:3457-3462(2014).
Tome, S; Simard, JP; et al. Tissue-specific mismatch repair protein expression: MSH3 is higher than MSH6 in multiple mouse tissues. DNA REPAIR 12:46-52(2013).
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