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MSH5

Official Full Name

mutS homolog 5
Overview

This gene encodes a member of the mutS family of proteins that are involved in DNA mismatch repair and meiotic recombination. This protein is similar to a Saccharomyces cerevisiae protein that participates in segregation fidelity and crossing-over events during meiosis. This protein plays a role in promoting ionizing radiation-induced apoptosis. This protein forms hetero-oligomers with another member of this family, mutS homolog 4. Polymorphisms in this gene have been linked to various human diseases, including IgA deficiency, common variable immunodeficiency, and premature ovarian failure. Alternative splicing results multiple transcript variants. Read-through transcription also exists between this gene and the downstream chromosome 6 open reading frame 26 (C6orf26) gene.
Synonyms

MSH5; mutS homolog 5 (E. coli); mutS (E. coli) homolog 5; mutS protein homolog 5; G7; NG23; MUTSH5; MGC2939; DKFZp434C1615;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat

Source

E.coli
HEK293
HEK293T
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	MSH5-4118HCL	Recombinant Human MSH5 293 Cell Lysate	HEK293	N/A		Inquiry
Human	MSH5-2013H	Recombinant Human MSH5 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	MSH5-1240H	Recombinant Human MSH5 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	MSH5-5652H	Recombinant Human MSH5 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	MSH5-3844H	Recombinant Human MSH5 protein, His-tagged	E.coli	His	635-835 aa	$319 / 25ug
Mouse	Msh5-4187M	Recombinant Mouse Msh5 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Rat	MSH5-3788R	Recombinant Rat MSH5 Protein	Mammalian Cell	His		Inquiry
Rat	MSH5-3447R	Recombinant Rat MSH5 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	MSH5-3447R-B	Recombinant Rat MSH5 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein
MSH5 Related Articles

MSH5 involved in several pathways and played different roles in them. We selected most pathways MSH5 participated on our site, such as Cell Cycle, Meiosis, Meiotic recombination, which may be useful for your reference. Also, other proteins which involved in the same pathway with MSH5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Cell Cycle	HIST2H3C;CDC14AB;YWHAE;MAD2L2;RAD9A;PLK4;CDK6;CTDNEP1B;NDE1
Meiosis	STAG1;TEX12;MSH5;TERF2;SUN1;SYNE1;SYCE1;TEX15;DIDO1
Meiotic recombination	MSH5;SPO11;TEX15;PSMC3IP;MSH4;DMC1;MND1
Ovarian Infertility Genes	DMC1;SYNE2;ZP2;NRIP1;INHA;MSH5;NR5A1;ZP3;DAZL

MSH5 has several biochemical functions, for example, ATP binding, DNA-dependent ATPase activity, NOT damaged DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MSH5 itself. We selected most functions MSH5 had, and list some proteins which have the same functions with MSH5. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	RIPK3;PFKFB1;FICD;DDX27;FGFR1A;DYRK3;ACSL4;MOCS3;PKN2
DNA-dependent ATPase activity	SMARCA4;ERCC2;DHX36;CHD6;CDK7;DDX11;TTF2;RAD51B;RAD51C
NOT damaged DNA binding	MSH4;MSH5
mismatched DNA binding	MSH4;MLH3;MSH6;PMS1;TDG;MSH5;MLH1
protein binding	MSH5;IL6ST;EIF3H;MIEF1;ALK;USP42;SYN1;FYN;AIRE

MSH5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MSH5 here. Most of them are supplied by our site. Hope this information will be useful for your research of MSH5.

ABL1; MSH4; XRCC5; Brca1; Tecpr2; LRRK2; SGTB

Skeldon, SC; Semotiuk, K; et al. Patients with Lynch Syndrome Mismatch Repair Gene Mutations Are at Higher Risk for Not Only Upper Tract Urothelial Cancer but Also Bladder Cancer. EUROPEAN UROLOGY 63:379-385(2013).

Aceto, GM; De Lellis, L; et al. Nonfluorescent Denaturing HPLC-Based Primer-Extension Method for Allele-Specific Expression: Application to Analysis of Mismatch Repair Genes. CLINICAL CHEMISTRY 55:1711-1718(2009).