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MSL3

Official Full Name

male-specific lethal 3 homolog (Drosophila)
Overview

This gene encodes a nuclear protein that is similar to the product of the Drosophila male-specific lethal-3 gene. The Drosophila protein plays a critical role in a dosage-compensation pathway, which equalizes X-linked gene expression in males and females. Thus, the human protein is thought to play a similar function in chromatin remodeling and transcriptional regulation, and it has been found as part of a complex that is responsible for histone H4 lysine-16 acetylation. This gene can undergo X inactivation. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 7 and 8. [provided by RefSeq, Jul 2010]
Synonyms

MSL3; male-specific lethal 3 homolog (Drosophila); MSL3L1; male-specific lethal 3 homolog; MSL3-like 1; male-specific lethal-3 protein-like 1;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse

Source

HEK293
HEK293T
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	MSL3-4113HCL	Recombinant Human MSL3 293 Cell Lysate	HEK293	N/A		Inquiry
Human	MSL3-4112HCL	Recombinant Human MSL3 293 Cell Lysate	HEK293	N/A		Inquiry
Human	MSL3-5657H	Recombinant Human MSL3 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	MSL3-5290H	Recombinant Human MSL3 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	MSL3-6460HF	Recombinant Full Length Human MSL3 Protein, GST-tagged	In Vitro Cell Free System	GST	521 amino acids	Inquiry
Mouse	MSL3-10139M	Recombinant Mouse MSL3 Protein	Mammalian Cell	His		Inquiry
Mouse	Msl3-4190M	Recombinant Mouse Msl3 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Mouse	MSL3-5744M-B	Recombinant Mouse MSL3 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	MSL3-5744M	Recombinant Mouse MSL3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry

Involved Pathway
Protein Function
Interacting Protein

MSL3 involved in several pathways and played different roles in them. We selected most pathways MSL3 participated on our site, such as Chromatin modifying enzymes, Chromatin organization, HATs acetylate histones, which may be useful for your reference. Also, other proteins which involved in the same pathway with MSL3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Chromatin modifying enzymes	SMARCA4;MBIP;KAT7;PADI2;BRPF3;MSL1;PHF15;MSL3;CARM1
Chromatin organization	RUVBL2;KDM5B;SMARCD3B;ANO9A;SMYD2;SMARCB1B;KAT7A;ARID1A;SAP30L
HATs acetylate histones	EP400;MEAF6;MSL2A;KAT6B;ELP3;ANO9A;KANSL3;PHF20B;KAT6A

MSL3 has several biochemical functions, for example, DNA binding, methylated histone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MSL3 itself. We selected most functions MSL3 had, and list some proteins which have the same functions with MSL3. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	FOXE1;HOXA5;TSHZ1;RAD51AP1;RAD51C;SERPINA3;ZFML;ILF2;SWAP70
methylated histone binding	JHDM1D;RRP8;SUZ12;CDYL2;CBX5;MSH6;CBX4;L3MBTL2;KAT8

MSL3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MSL3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MSL3.

Kat8; CDK6; Map3k1; yitJ; p27958-pro_0000037566; DYRK1B