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MSLN

  • Official Full Name

    mesothelin

  • Overview

    Membrane-anchored forms of mesothelin may play a role in cellular adhesion. Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation. Mesothelin interacts with MUC16. The protein is expressed in lung and at low levels in the heart, placenta, kidney, and mesothelial cells. Mestothelin is highly expressed in mesotheliomas, ovarian cancers, and some squamous cell carcinomas (at protein level). Both MPF and the cleaved form of mesothelin are N-glycosylated. It is proteolytically cleaved by a furin-like convertase to generate megakaryocyte- potentiating factor (MPF), and the cleaved form of mesothelin.
  • Synonyms

    MPF; SMRP; CAK1 antigen; megakaryocyte potentiating factor; pre-pro-megakaryocyte-potentiating factor; soluble MPF mesothelin related protein;

  • Recombinant Proteins
  • GMP Proteins
  • Cell & Tissue Lysates
  • Chromatography Reagents
  • Protein Pre-coupled Magnetic Beads
  • Cynomolgus
  • Human
  • Mouse
  • Rat
  • CHO
  • CHO cells
  • E.coli
  • HEK293
  • HEK293F
  • HEK293T
  • Human Cell
  • Human cells
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • NS0
  • Wheat Germ
  • Yeast
  • Avi|His
  • C
  • 6His
  • Avi
  • Fc
  • hFc
  • His
  • mFc
  • 6×His
  • Myc
  • DDK
  • GST
  • His (Fc)
  • His\Avi
  • His|Avi
  • His|GST
  • His|SUMO
  • human|IgG1|Fc
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MSLN-528H Active Recombinant Human MSLN Protein, Fc-tagged HEK293 Fc Glu296 - Ser592
Human MSLN-642H Active Recombinant Human MSLN, His-tagged, Biotinylated Human Cell His
Human MSLN-10625H Active Recombinant Human MSLN Protein, Fc-tagged Human cells Fc
Human MSLN-301H Active Recombinant Human MSLN, His-tagged Mammalian cells His
Human MSLN-10625HAF488 Active Recombinant Human MSLN Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc
Human MSLN-528HAF647 Active Recombinant Human MSLN Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc Glu296-Ser592
Human MSLN-10625HAF647 Active Recombinant Human MSLN Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc
Human MSLN-001H Active Recombinant Human MSLN Protein, His-tagged HEK293 His
Human MSLN-10625HF Active Recombinant Human MSLN Protein, Fc-tagged, FITC conjugated HEK293 Fc
Human MSLN-051H Active Recombinant Human MSLN protein, Fc/Avi-tagged, Biotinylated CHO cells Fc/Avi Glu296-Gly580
Human MSLN-315H Active Recombinant Human MSLN Protein (Glu 296 - Gly 580), His-tagged, FITC-Labeled HEK293 His Glu 296 - Gly 580
Human MSLN-8392H Active Recombinant Human MSLN Protein Human cells N/A
Human MSLN-0382H Active Recombinant Human MSLN protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Glu296-Thr600
Human MSLN-15H Active Recombinant Human MSLN Protein, His-tagged, Alexa Fluor® 488 conjugated NS0 His
Human MSLN-316H Active Recombinant Human MSLN Protein (Glu 296 - Gly 580), Fc-tagged, FITC-Labeled HEK293 Fc Glu 296 - Gly 580
Human MSLN-16H Active Recombinant Human MSLN Protein, His-tagged, Alexa Fluor® 647 conjugated NS0 His
Human MSLN-976HG Active GMP Recombinant Human MSLN protein HEK293 DNA sequence encoding Human MSLN(GenBank: AAH09272.1) was expressed with His tag at the C-terminal.
Human MSLN-528HAF555 Active Recombinant Human MSLN Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc Glu296-Ser592
Human MSLN-528HAF488 Active Recombinant Human MSLN Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc Glu296-Ser592
Human MSLN-528HF Active Recombinant Human MSLN Protein, Fc-tagged, FITC conjugated HEK293 Fc Glu296-Ser592
Human MSLN-10625HAF555 Active Recombinant Human MSLN Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc
Human MSLN-340H Recombinant Human MSLN protein, Fc-tagged HEK293 human/IgG1/Fc Glu296-Gly580
Human MSLN-01H Recombinant Human Mesothelin HEK293 N/A
Human MSLN-7350H Recombinant Human MSLN, Fc tagged Human Cell Fc
Human MSLN-8558H Recombinant Human MSLN, Fc tagged Human Cell Fc
Human MSLN-1062H Recombinant Human MSLN, GST-tagged E.coli GST 273-621aa
Human MSLN-185H Active Recombinant Human MSLN Protein, Fc-tagged HEK293 Fc
Human MSLN-2967H Recombinant Human MSLN, Fc Tagged, Biotinylated Human Cell Fc Glu296-Gly580
Human MSLN-7818H Recombinant Human MSLN protein, Avi & His-tagged HEK293 Avi/His Glu 296 - Gly 580
Human MSLN-8559H Recombinant Human MSLN protein, His-tagged HEK293 His Leu37-Arg286
Human MSLN-491H Recombinant Human MSLN Protein HEK293 N/A
Human MSLN-10623H Recombinant Human MSLN protein, His-tagged, Biotin Labeled. HEK293 His Glu 296 - Gly 580
Human MSLN-302H Active Recombinant Human MSLN protein, His-tagged HEK293 His Glu296-Gly580
Human MSLN-1316HCL Recombinant Human MSLN cell lysate Human Cell N/A
Human MSLN-1343HCL Recombinant Human MSLN cell lysate Human Cell N/A
Human MSLN-10625HA Recombinant Human MSLN protein, Fc-tagged, APC labeled HEK293 Fc
Human MSLN-2092H Recombinant Human MSLN Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human MSLN-5659H Recombinant Human MSLN Protein, GST-tagged Wheat Germ GST
Human MSLN-303H Active Recombinant Human MSLN Protein, His-Avi-tagged, Biotinylated HEK293 His/Avi
Human MSLN-528HP Recombinant Human MSLN protein, Fc-tagged, R-PE labeled HEK293 Fc
Human MSLN-1538H Recombinant Human MSLN protein, His & GST-tagged E.coli His/GST Glu400~Leu615
Human MSLN-8558HP Recombinant Human MSLN protein, Fc-tagged, R-PE labeled HEK293 Fc
Human MSLN-304H Active Recombinant Human MSLN protein, Fc-Avi-tagged, Biotinylated HEK293 Fc-Avi Glu296-Gly580
Human MSLN-7350HP Recombinant Human MSLN protein, Fc-tagged, R-PE labeled HEK293 Fc
Human MSLN-151H Recombinant Human MSLN Protein, His-tagged Human cells His
Human MSLN-8558HA Recombinant Human MSLN protein, Fc-tagged, APC labeled HEK293 Fc
Human MSLN-185HP Recombinant Human MSLN protein, Fc-tagged, R-PE labeled HEK293 Fc
Human MSLN-266H Recombinant Human MSLN protein, His-tagged, Biotinylated HEK293 His Met1-Arg286
Human MSLN-340HB Recombinant Human MSLN Protein, hFc-tagged, Biotinylated HEK293 hFc Glu296-Gly580
Human MSLN-318H Recombinant Human MSLN Protein (Glu 296 - Gly 580), His-tagged, PE-Labeled HEK293 His Glu 296 - Gly 580
Human MSLN-185HA Recombinant Human MSLN protein, Fc-tagged, APC labeled HEK293 Fc
Human MSLN-1139H Recombinant Human MSLN Protein, His-tagged HEK293F N-His Glu296-Ser606
Human MSLN-185HAF488 Active Recombinant Human MSLN Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc 545
Human MSLN-7350HAF488 Recombinant Human MSLN Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc 491
Human MSLN-340HP Recombinant Human MSLN protein, Fc-tagged, R-PE labeled HEK293 Fc
Human MSLN-340HAF488 Recombinant Human MSLN Protein, hFc-tagged, Alexa Fluor 488 conjugated HEK293 hFc Glu296-Gly580
Human MSLN-10625HP Recombinant Human MSLN protein, Fc-tagged, R-PE labeled HEK293 Fc
Human MSLN-8558HAF488 Recombinant Human MSLN Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc 545
Human MSLN-340HA Recombinant Human MSLN protein, Fc-tagged, APC labeled HEK293 Fc
Human MSLN-5043H Recombinant Human MSLN protein, His-Myc-tagged HEK293 His/Myc 296-580aa
Human MSLN-528HA Recombinant Human MSLN protein, Fc-tagged, APC labeled HEK293 Fc
Human MSLN-6461HF Recombinant Full Length Human MSLN Protein, GST-tagged In Vitro Cell Free System GST 621 amino acids
Human MSLN-072H Recombinant Human MSLN Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human MSLN-185HAF555 Active Recombinant Human MSLN Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc 545
Human MSLN-7350HA Recombinant Human MSLN protein, Fc-tagged, APC labeled HEK293 Fc
Human MSLN-382H Recombinant Human MSLN Protein, His-tagged HEK293 His 630
Human MSLN-7350HAF555 Recombinant Human MSLN Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc 491
Human MSLN-381H Recombinant Human MSLN Protein, His-tagged, Biotinylated HEK293 His 630
Human MSLN-185HF Active Recombinant Human MSLN Protein, Fc-tagged, FITC conjugated HEK293 Fc 545
Human MSLN-383H Recombinant Human MSLN Protein, Fc-tagged HEK293 Fc 630
Human MSLN-8558HAF555 Recombinant Human MSLN Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc 545
Human MSLN-317H Active Recombinant Human MSLN Protein (Glu 296 - Gly 580), His-tagged, GFP Fusion HEK293 His Glu 296 - Gly 580
Human MSLN-2457H Recombinant Human MSLN Protein, His-tagged E.coli N-His Glu296-Ser606
Human MSLN-384H Recombinant Human MSLN Protein, His-tagged HEK293 His 630
Human MSLN-185HAF647 Active Recombinant Human MSLN Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc 545
Human MSLN-76H Recombinant Human MSLN Protein, His-tagged HEK293 His
Human MSLN-75H Recombinant Human MSLN Protein, hFc-tagged HEK293 hFc
Human MSLN-31H Recombinant Human MSLN Protein, His-tagged HEK293 His Glu296-Ser598
Human MSLN-340HAF647 Recombinant Human MSLN Protein, hFc-tagged, Alexa Fluor 647 conjugated HEK293 hFc Glu296-Gly580
Human MSLN-3527H Recombinant Human MSLN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human MSLN-380H Recombinant Human MSLN Protein, Fc-tagged, Biotinylated HEK293 Fc 630
Human MSLN-32H Recombinant Human MSLN Protein, Fc-tagged HEK293 Fc Glu296-Ser598
Human MSLN-340HAF555 Recombinant Human MSLN Protein, hFc-tagged, Alexa Fluor 555 conjugated HEK293 hFc Glu296-Gly580
Human MSLN-4681H Recombinant Human MSLN Protein, His-tagged, APC-Labeled HEK293 His Glu 296 - Gly 580
Human MSLN-0390H Active Recombinant Human MSLN protein, His-tagged, Biotinylated HEK293 His Glu296-Gly580
Human MSLN-0387H Active Recombinant Human MSLN protein, Fc-tagged, FITC-Labeled HEK293 Fc Glu296-Gly580
Human MSLN-7350HF Recombinant Human MSLN Protein, Fc-tagged, FITC conjugated HEK293 Fc 491
Human MSLN-3880H Recombinant Human MSLN Protein (Glu296-Ser598), N-His tagged E.coli N-His Glu296-Ser598
Human MSLN-651H Recombinant Human MSLN Protein (Glu296-Gly580), C-mFc and 6×His-tagged HEK293 C-mFc and 6×His Glu296-Gly580
Human MSLN-0388H Active Recombinant Human MSLN protein, Fc-tagged, FITC-Labeled HEK293 Fc Glu296-Gly580
Human MSLN-8558HF Recombinant Human MSLN Protein, Fc-tagged, FITC conjugated HEK293 Fc 545
Human MSLN-7689M Active MSLN protein-coupled magnetic Beads HEK293 Glu 296 - Gly 580 (R309P)
Human MSLN-4682H Recombinant Human MSLN Protein, His-tagged, PE-Labeled HEK293 His Glu 296 - Gly 580
Human MSLN-0389H Active Recombinant Human MSLN protein, Fc-tagged, Biotinylated HEK293 Fc Glu296-Gly580
Human MSLN-09H Recombinant Human MSLN Protein, C-6His-Avi tagged, Biotinylated Human Cell C-6His-Avi Glu296-Ser598
Human MSLN-3297H Recombinant Human MSLN protein(Glu296-Gly580), His-tagged HEK293 C-His Glu296-Gly580
Human MSLN-4684H Active Recombinant Human MSLN Protein, His-tagged, PE-Labeled HEK293 His Glu 296 - Gly 580
Human MSLN-4680H Active Recombinant Human MSLN Protein, His-tagged, APC-Labeled HEK293 His Glu 296 - Gly 580
Human MSLN-181H Recombinant Human MSLN Protein, His\Avi-tagged Human Cell His\Avi
Human MSLN-3874H Recombinant Human MSLN Protein (Glu296-Gly580), C-His tagged Mammalian cells C-His Glu296-Gly580
Human MSLN-3527H-B Recombinant Human MSLN Protein Pre-coupled Magnetic Beads HEK293
Human MSLN-3881H Recombinant Human MSLN Protein (Glu310-Gly588), C-His tagged Mammalian cells C-His Glu310-Gly588
Human MSLN-0379H Active Recombinant Human MSLN protein, His-tagged, Alexa Fluor 488-Labeled HEK293 His Glu296-Gly580
Human MSLN-1339H Recombinant Human MSLN protein(Met1-Arg286), hFc-tagged HEK293 C-hFc Met1-Arg286
Human MSLN-0380H Active Recombinant Human MSLN protein, His-tagged, Alexa Fluor 647-Labeled HEK293 His Glu296-Gly580
Human MSLN-0381H Recombinant Human MSLN protein, His-tagged, Alexa Fluor 555-Labeled HEK293 His Glu296-Gly580
Human MSLN-3875H Recombinant Human MSLN Protein (Glu296-Ser598), C-Fc tagged Mammalian cells C-Fc Glu296-Ser598
Human MSLN-3876H Recombinant Human MSLN Protein (Glu296-Ser598), C-His tagged Mammalian cells C-His Glu296-Ser598
Human MSLN-3877H Recombinant Human MSLN Protein (Leu37-Arg286), C-Fc tagged Mammalian cells C-Fc Leu37-Arg286
Human MSLN-3878H Recombinant Human MSLN Protein (Leu37-Arg286), C-His tagged Mammalian cells C-His Leu37-Arg286
Human MSLN-7350HAF647 Recombinant Human MSLN Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc 491
Human MSLN-8558HAF647 Recombinant Human MSLN Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc 545
Human MSLN-340HF Recombinant Human MSLN Protein, hFc-tagged, FITC conjugated HEK293 hFc Glu296-Gly580
Mouse Msln-32M Active Recombinant Mouse Msln protein, His-tagged CHO His Asp298-Ser600
Mouse Msln-33M Active Recombinant Mouse Msln protein, His-tagged HEK293 His Asp298-Gly582
Mouse MSLN-0384M Active Recombinant Mouse MSLN protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Asp298-Ser600
Mouse Msln-35M Recombinant Mouse Msln Protein, Fc-tagged HEK293 Fc Glu296 - Ser592
Mouse Msln-34M Recombinant Mouse Msln protein, His-tagged E.coli His Pro345~Asn548
Mouse MSLN-10141M Recombinant Mouse MSLN Protein Mammalian Cell His
Mouse MSLN-5745M Recombinant Mouse MSLN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse MSLN-5745M-B Recombinant Mouse MSLN Protein Pre-coupled Magnetic Beads HEK293
Mouse Msln-4191M Active Recombinant Mouse Msln Protein, His-tagged HEK293 His Asp298-Gly582
Mouse Msln-267M Recombinant Mouse Msln Protein, Asp298-Ser600, C-His tagged, Biotinylated HEK293 C-His Asp298-Ser600
Mouse MSLN-669M Recombinant Mouse MSLN Protein (298-600 aa), His-SUMO-tagged E.coli His/SUMO 298-600 aa
Mouse Msln-4192M Recombinant Mouse Msln Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Msln-5473M Recombinant Mouse Msln protein, His-tagged Yeast His 298-600aa
Mouse MSLN-0386M Active Recombinant Mouse MSLN protein, His-tagged HEK293 His Asp298-Ser600
Mouse Msln-1539M Recombinant Mouse Msln protein, His & GST-tagged E.coli His/GST Pro345~Asn548 (Accession # Q61468)
Rat MSLN-0383R Active Recombinant Rat MSLN protein, His-tagged HEK293 His Asp298-Ser600
Rat MSLN-3790R Recombinant Rat MSLN Protein Mammalian Cell His
Rat MSLN-3449R Recombinant Rat MSLN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat MSLN-3449R-B Recombinant Rat MSLN Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus MSLN-0385C Active Recombinant Cynomolgus MSLN protein, His-tagged HEK293 His Asp296-Gly580
Cynomolgus MSLN-25C Recombinant Cynomolgus MSLN Protein, Fc tagged Human cells Fc
Cynomolgus MSLN-26C Recombinant Cynomolgus MSLN Protein, C-His tagged Human cells C-His
Cynomolgus MSLN-006C Recombinant Cynomolgus MSLN Protein, Asp296-Gly580, C-His tagged, Biotinylated HEK293 C-His Asp296-Gly580
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MSLN Related Articles
  • MSLN Related Research Area

MSLN involved in several pathways and played different roles in them. We selected most pathways MSLN participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MSLN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

MSLN has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MSLN itself. We selected most functions MSLN had, and list some proteins which have the same functions with MSLN. You can find most of the proteins on our site.

Function Related Protein
protein bindingKHDRBS1;CLASP1;DUSP15;AKIP1;RPUSD4;SART1;CCDC64;RAB8A;ZBED4

MSLN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MSLN here. Most of them are supplied by our site. Hope this information will be useful for your research of MSLN.

RSG1

Samineni, D; Li, C; et al. PHARMACOKINETICS (PK) OF ANTI-MSLN ANTIBODY DRUG CONJUGATE (ADC) IN PATIENTS WITH UNRESECTABLE PANCREATIC OR PLATINUM-RESISTANT OVARIAN CANCER IN A PHASE I STUDY.. CLINICAL PHARMACOLOGY & THERAPEUTICS 97:S46-S46(2015).
Scales, SJ; Gupta, N; et al. An Antimesothelin-Monomethyl Auristatin E Conjugate with Potent Antitumor Activity in Ovarian, Pancreatic, and Mesothelioma Models. MOLECULAR CANCER THERAPEUTICS 13:2630-2640(2014).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
What is the primary role of MSLN in normal tissues? 12/07/2022

MSLN is normally expressed in mesothelial cells, playing a role in cell adhesion.

How is MSLN expression altered in cancerous cells? 03/19/2022

In cancer, MSLN expression is significantly upregulated.

In which types of cancer is MSLN overexpressed? 03/28/2021

MSLN is overexpressed in mesothelioma, ovarian, and pancreatic cancers.

Are there any therapeutic strategies targeting MSLN in cancer treatment? 02/25/2020

Therapies targeting MSLN include antibody-drug conjugates and CAR-T cell therapies.

How can MSLN levels be detected and measured in clinical settings? 10/07/2019

MSLN levels can be assessed through immunohistochemistry and serum biomarker tests.

What is the prognostic significance of MSLN overexpression in cancer patients? 11/23/2018

MSLN overexpression is often associated with poor prognosis in cancer patients.

How does MSLN contribute to cancer progression and metastasis? 11/07/2018

MSLN promotes tumor cell proliferation, invasion, and resistance to apoptosis.

Customer Reviews (3)

Write a review
Reviews
05/22/2022

    Very satisfied, great product.

    03/06/2022

      Product is high-quality.

      09/30/2021

        Excellent for experiments, reliable.

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