MTAP
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Official Full Name
methylthioadenosine phosphorylase
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Overview
MTAP is an enzyme that is essential for the salvage pathway for both adenine and methionine synthesis. MTAP catalyzes the cleavage of 5'-methylthioadenosine into adenine and 5-methylthio-D-ribose-1-phosphate. Adenine is then used to generate AMP whereas 5 -
Synonyms
MTAP; methylthioadenosine phosphorylase; S-methyl-5-thioadenosine phosphorylase; c86fus; MSAP; MTAPase; MTA phosphorylase; MeSAdo phosphorylase; 5-methylthioadenosine phosphorylase;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Cynomolgus Monkey
- Human
- Mouse
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- MTAP Related Articles
MTAP involved in several pathways and played different roles in them. We selected most pathways MTAP participated on our site, such as Cysteine and methionine metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with MTAP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cysteine and methionine metabolism | DNMT3A;DNMT4;LDHAL6A;AHCYL1;GCLM;DNMT3AB;MTR;MDH1AA;MDH2 |
| Metabolic pathways | POLR2F;ALOX12E;PIP5K1BB;PLA2G4A;AOX2P;CHKB;CYP2U1;BPGM;POLA2 |
MTAP has several biochemical functions, for example, S-methyl-5-thioadenosine phosphorylase activity, phosphorylase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MTAP itself. We selected most functions MTAP had, and list some proteins which have the same functions with MTAP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| S-methyl-5-thioadenosine phosphorylase activity | |
| phosphorylase activity | PYGMA;MTAP;TYMP;PYGMB |
| protein binding | CCNB3;KCNB1;CXCL2;HMGN2;Fgf15;PSMA6;CENPL;STARD3;TUBB2A |
MTAP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MTAP here. Most of them are supplied by our site. Hope this information will be useful for your research of MTAP.
CENPH; LYRM1; NP; CDC25A; RELB; FOLH1; MAP1LC3A
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, the presence or absence of MTAP is being investigated as a potential predictive biomarker for the response to specific anticancer therapies.
Yes, molecular diagnostic techniques can assess MTAP status in tumors, aiding in cancer diagnosis and prognosis.
One challenge is the development of targeted therapies that selectively exploit MTAP deficiency without causing significant side effects in normal cells.
Researchers are exploring targeted therapies that exploit MTAP deficiency in cancer cells, aiming for more effective and selective treatments.
MTAP-deficient cells may be more sensitive to certain chemotherapeutic agents, offering a potential therapeutic advantage in cancer treatment.
Customer Reviews (3)
Write a reviewWhat sets the MTAP protein apart is not only its outstanding quality but also the excellent technical support provided by the manufacturer.
the MTAP protein's versatility extends beyond its proven usefulness in in vitro experiments.
Whether studying angiopoietin signaling pathways, vascular remodeling, or endothelial cell biology, the MTAP protein is an invaluable tool for researchers.
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