MTHFR
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Official Full Name
methylenetetrahydrofolate reductase (NAD(P)H)
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Overview
MTHFR catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. Genetic variation in this gene influences susceptibility to occlusive vascular disease, neural tube defects, colon cancer and acute leukemia, and mutations in this gene are associated with methylenetetrahydrofolate reductase deficiency. -
Synonyms
MTHFR; methylenetetrahydrofolate reductase (NAD(P)H); 5,10 methylenetetrahydrofolate reductase (NADPH); methylenetetrahydrofolate reductase; 5,10-methylenetetrahydrofolate reductase (NADPH);
- Cell & Tissue Lysates
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Cynomolgus Monkey
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- Yeast
- Flag
- His
- His (Fc)
- Avi
- His|SUMO
- His|T7
- Myc
- DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- MTHFR Related Articles
MTHFR involved in several pathways and played different roles in them. We selected most pathways MTHFR participated on our site, such as One carbon pool by folate, Metabolic pathways, Carbon metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with MTHFR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| One carbon pool by folate | MTHFR;ST20-MTHFS;FTCD;MTHFD2L;MTFMT;DHFRL1;MTHFS;MTHFD1;ALDH1L2 |
| Metabolic pathways | POLR1D;HK1;ENOPH1;NT5C1AA;HPSE;UQCRC1;AMY2A3;UCK2A;DLAT |
| Carbon metabolism | PKLR;TPI1;GPIB;GLUD1A;HAO1;MTHFR;PFKP;RPE;TALDO1 |
MTHFR has several biochemical functions, for example, NADP binding, flavin adenine dinucleotide binding, methylenetetrahydrofolate reductase (NAD(P)H) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MTHFR itself. We selected most functions MTHFR had, and list some proteins which have the same functions with MTHFR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NADP binding | FMO2;PGD;NOX1;NDOR1;POR;MIOX;GAPDH;HMGCRA;DPYD |
| flavin adenine dinucleotide binding | AOX1;ACADS;FMO1;NOS1;GSR;FOXRED2;AIFM2;SQLEA;ACAD11 |
| methylenetetrahydrofolate reductase (NAD(P)H) activity | |
| modified amino acid binding | DPEP1;CBS;CPS1;MUT;MTHFR;NOX4 |
| protein complex binding | TULP3;ABI2;FADD;OTOF;CPD;PRMT5;CDK5RAP1;UQCRC2;LRP1 |
MTHFR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MTHFR here. Most of them are supplied by our site. Hope this information will be useful for your research of MTHFR.
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