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MTIF3

Official Full Name

mitochondrial translational initiation factor 3
Overview

This gene encodes a translation initiation factor that is involved in mitochondrial protein synthesis. Polymorphism in this gene is associated with the onset of Parkinsons disease. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 5.
Synonyms

MTIF3; mitochondrial translational initiation factor 3; translation initiation factor IF-3, mitochondrial; IF 3mt; IF3(mt); IF 3; IF3; IF3Mt; Mt; Translation initiation factor IF 3, mitochondrial precursor; IF-3(Mt);

Type

Cell & Tissue Lysates
Recombinant Proteins

Species

Chicken
Human
Mouse

Source

E.coli
HEK293
HEK293T
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	MTIF3-4079HCL	Recombinant Human MTIF3 293 Cell Lysate	HEK293	N/A		Inquiry
Human	MTIF3-6127H	Recombinant Human MTIF3 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	MTIF3-5708H	Recombinant Human MTIF3 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	MTIF3-2150H	Recombinant Human MTIF3 Protein (1-278 aa), GST-tagged	E.coli	GST	1-278 aa	Inquiry
Human	MTIF3-6531HF	Recombinant Full Length Human MTIF3 Protein, GST-tagged	In Vitro Cell Free System	GST	278 amino acids	Inquiry
Mouse	Mtif3-4213M	Recombinant Mouse Mtif3 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Chicken	MTIF3-5159C	Recombinant Chicken MTIF3	Mammalian Cell	His		Inquiry
Chicken	MTIF3-5158C	Recombinant Chicken MTIF3	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
MTIF3 Related Articles

MTIF3 involved in several pathways and played different roles in them. We selected most pathways MTIF3 participated on our site, such as Mitochondrial translation, Mitochondrial translation initiation, Organelle biogenesis and maintenance, which may be useful for your reference. Also, other proteins which involved in the same pathway with MTIF3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Mitochondrial translation	MTIF3;MRPL49;MRPL51;GFM1;MRPL37;MRPL39;MRPL3;PTCD3;MTFMT
Mitochondrial translation initiation	ICT1;MRPL41;AURKAIP1;MRPL3;MRPS22;MRPS26;MRPS36;MRPL54;MRPS31
Organelle biogenesis and maintenance	PKD1;ATAT1;MRPS31;MRPS25;CNGA2;TMEM67;WDR35;MRRF;MRPS30

MTIF3 has several biochemical functions, for example, protein binding, ribosomal small subunit binding, translation factor activity, RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MTIF3 itself. We selected most functions MTIF3 had, and list some proteins which have the same functions with MTIF3. You can find most of the proteins on our site.

Function	Related Protein
protein binding	CHRD;NPM3;ABI1;EEA1;SOX1;FOXO3B;C15orf57;EXOSC2;HMBOX1
ribosomal small subunit binding	CPEB2;NPM1;PIM1;ERAL1;DDX3X;DHX29;MTIF3;NME1;PTCD3
translation factor activity, RNA binding	PPP1R2P9;GTF2H3;CPEB4;CPEB2;EIF1AX;CPEB1A;GTF2H2;EIF4E2;CPEB1
translation initiation factor activity	EIF2D;COPS5;EIF4G2;EIF3B;EIF4BB;EIF4E2;AGO2;EIF2S3;EIF4G1

MTIF3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MTIF3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MTIF3.

SIAH1; MAPK1; 2_aha_camp

Niu, YN; Liu, QQ; et al. Alternative Messenger RNA Splicing of Autophagic Gene Beclin 1 in Human B-cell Acute Lymphoblastic Leukemia Cells. ASIAN PACIFIC JOURNAL OF CANCER PREVENTION 15:2153-2158(2014).

Schwer, CI; Stoll, P; et al. Carbon monoxide releasing molecule-2 CORM-2 represses global protein synthesis by inhibition of eukaryotic elongation factor eEF2. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 45:201-212(2013).