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MTM1

  • Official Full Name

    myotubularin 1

  • Overview

    This gene encodes a dual-specificity phosphatase that acts on both phosphotyrosine and phosphoserine. It is required for muscle cell differentiation and mutations in this gene have been identified as being responsible for X-linked myotubular myopathy.
  • Synonyms

    MTM1; myotubularin 1; myotubular myopathy 1; myotubularin; CNM; MTMX; XLMTM;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Rat
  • Rhesus Macaque
  • Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MTM1-1086H Recombinant Human MTM1, His-tagged E.coli His N-term-362aa
Human MTM1-4078HCL Recombinant Human MTM1 293 Cell Lysate HEK293 N/A
Human MTM1-232H Recombinant Human MTM1 Protein (Met1-Phe603), N-His tagged, Animal-free, Carrier-free E.coli N-His Met1-Phe603
Human MTM1-6532HF Recombinant Full Length Human MTM1 Protein, GST-tagged In Vitro Cell Free System GST 603 amino acids
Human MTM1-5709H Recombinant Human MTM1 Protein, GST-tagged Wheat Germ GST
Rat MTM1-3812R Recombinant Rat MTM1 Protein Mammalian Cell His
Rat MTM1-3471R Recombinant Rat MTM1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat MTM1-3471R-B Recombinant Rat MTM1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque MTM1-2900R Recombinant Rhesus monkey MTM1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque MTM1-2720R-B Recombinant Rhesus Macaque MTM1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque MTM1-2720R Recombinant Rhesus Macaque MTM1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) RFL12323SF Recombinant Full Length Saccharomyces Cerevisiae Mitochondrial Carrier Protein Mtm1(Mtm1) Protein, His-Tagged E.coli expression system His Full Length (1-366)
Zebrafish MTM1-3578Z Recombinant Zebrafish MTM1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

MTM1 involved in several pathways and played different roles in them. We selected most pathways MTM1 participated on our site, such as Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with MTM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Inositol phosphate metabolismPLCD3;PLCB4;NUDT10;PLCH1;PLCZ1;MTMR4;PLCG1;PTENB;MTMR7
Metabolic pathwaysATP6V0C;NDUFA12;CYP2P8;NME1;ADSSL;GALCB;Acsm2a;UGDH;NADKD1
Phosphatidylinositol signaling systemPLCD1A;PIK3CG;INPP5K;INPP1;ITPK1A;MTMR3;PIK3C2G;IP6K2;CALM2B

MTM1 has several biochemical functions, for example, intermediate filament binding, phosphatidylinositol binding, phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MTM1 itself. We selected most functions MTM1 had, and list some proteins which have the same functions with MTM1. You can find most of the proteins on our site.

Function Related Protein
intermediate filament bindingNME2;PKP1;PKP2;EVPLA;NES;SYNM;MTM1;EVPL
phosphatidylinositol bindingPASK;TULP3;SNX5;SNX17;PLD1A;SNX29;SNX27A;SH3PXD2A;ARHGAP33
phosphatidylinositol-3,5-bisphosphate 3-phosphatase activityMTMR1;CTDSPL2A;SACM1L;MTM1;SACM1LA;SGPP2;SACM1LB;MTMR3;CTDSPL2B
phosphatidylinositol-3-phosphatase activitySACM1L;PTEN;MTMR1B;MTM1;MTMR3;MTMR2;MTMR14;MTMR1A;FIG4
phosphoprotein phosphatase activityPPP1CC;PPP1CBL;PTPN11;PPP1R3B;PTPRZ1;PPM1LB;PPP2CA;MTM1;PTPN4A
protein bindingZBTB7C;ATCAY;BMPR1B;SCOC;DPH2;COPS6;DDX42;KIR2DL3;a
protein tyrosine phosphatase activityCDC14AB;PTPRDB;PTPRK;CDKN3;MDP1;PTPN11A;PTPRA;SSH3;DUSP13A

MTM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MTM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MTM1.

DES; MTMR12; BIN1

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