MUC16
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Official Full Name
mucin 16, cell surface associated
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Overview
CA-125 (cancer antigen 125 or carbohydrate antigen 125) also known as mucin 16 or MUC16 is a protein that in humans is encoded by the MUC16 gene. MUC16 is a member of the mucin family glycoproteins. CA-125 has found application as a tumor marker or biomarker that may be elevated in the blood of some patients with specific types of cancers, or other benign conditions. MUC16 (CA125) is a serum marker that is used routinely in gynecologic practice to monitor patients with ovarian cancer. It is a mullerian duct differentiation antigen that is overexpressed in epithelial ovarian cancer cells and secreted into the blood, although its expression is not entirely confined to ovarian cancer. Most biochemical studies have concluded that MUC16 is a high molecular mass glycoprotein, although estimates of its size range from 200?to 2000?kDa with smaller “subunits” being described by some investigators. -
Synonyms
MUC16; mucin 16, cell surface associated; CA125; mucin-16; CA-125; MUC-16; CA125 ovarian cancer antigen; ovarian carcinoma antigen CA125; ovarian cancer-related tumor marker CA125; FLJ14303; Igovomab; Indimacis-125; 171656-50-1; Abagovomab; 792921-10-9;
- Native Proteins
- Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- CHO
- E.coli
- HEK293
- HEK293 cells
- Human Ascites Fluid
- Human Cell
- Insect Cell
- Wheat Germ
- Avi|Fc
- C
- Fc
- Avi
- His
- Fc\Avi
- GST
- N/A
- N
- MUC16 Related Articles
MUC16 involved in several pathways and played different roles in them. We selected most pathways MUC16 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MUC16 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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MUC16 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by MUC16 itself. We selected most functions MUC16 had, and list some proteins which have the same functions with MUC16. You can find most of the proteins on our site.
| Function | Related Protein |
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MUC16 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MUC16 here. Most of them are supplied by our site. Hope this information will be useful for your research of MUC16.
- Q&As
- Reviews
Q&As (7)
Ask a questionMUC16 works with other mucins and immune components to maintain epithelial barrier function and immune responses.
It aids in forming the mucosal barrier, protecting against pathogens and mechanical damage.
Targeting MUC16 in cancer therapy, especially in ovarian cancer, could be effective in inhibiting tumor growth and spread.
Altered MUC16 activity can impact the body's defense against inflammation and infection.
MUC16, a mucin protein, is essential for maintaining the protective mucous layer on epithelial surfaces.
MUC16 is associated with cancer progression, particularly in ovarian cancer, where it may facilitate tumor growth and metastasis.
Genetic variations in MUC16 can lead to differences in mucosal integrity and potentially influence cancer susceptibility.
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