MUSK
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Official Full Name
muscle, skeletal, receptor tyrosine kinase
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Overview
This gene encodes a muscle-specific tyrosine kinase receptor. The encoded protein may play a role in clustering of the acetylcholine receptor in the postsynaptic neuromuscular junction. Mutations in this gene have been associated with congenital myasthenic syndrome. Alternatively spliced transcript variants have been described. -
Synonyms
MUSK; muscle, skeletal, receptor tyrosine kinase; muscle, skeletal receptor tyrosine-protein kinase; muscle-specific kinase receptor; muscle-specific tyrosine-protein kinase receptor; MGC126323; MGC126324;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- Insect Cell
- Insect Cells
- Mammalian Cell
- Sf21
- Sf9 Insect Cell
- Wheat Germ
- Yeast
- C
- His
- DDK|His
- GST
- GST|His
- His (Fc)
- Avi
- His|SUMO|Myc
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- MUSK Related Articles
- MUSK Related Research Area
MUSK involved in several pathways and played different roles in them. We selected most pathways MUSK participated on our site, such as ECM proteoglycans, Extracellular matrix organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with MUSK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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ECM proteoglycans | COL9A1;LRP4;HAPLN1;MUSK;MATN1;BGNB;DAG1;VCANB;COL9A3 |
Extracellular matrix organization | FBLN1;COL9A1B;BMP1A;LRP4;FURINA;EFEMP1;DMD;BMP10;COL6A3 |
MUSK has several biochemical functions, for example, ATP binding, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MUSK itself. We selected most functions MUSK had, and list some proteins which have the same functions with MUSK. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
ATP binding | TOR1;HSPH1;ACSM3;PCCA;MYO18A;ACACB;DNAHC8;MTHFD1B;FRK |
metal ion binding | KLF2A;PAPD7;ZFP865;CHD4A;BTR30;MAT1A;DNMT3B;SP8B;GALNT14 |
protein binding | TAF6L;ATP6V0A1;WARS;ZNF155;ERCC6;MED16;AKAP17A;SUV39H1;POT1 |
protein tyrosine kinase activity | MAP3K11;EPHB2;MAP2K4;NTRK2B;RET;FGFR1A;EGFR;SYK;FGFR1 |
transmembrane receptor protein tyrosine kinase activity | AXL;CADM2B;NTRK3;ERBB2;TYRO3;ERBB4;ROR2;IGF1RB;EPHA4A |
MUSK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MUSK here. Most of them are supplied by our site. Hope this information will be useful for your research of MUSK.
HSP90AB1; HSP90AA1; FKBP5; CDC37; HSP90AB1; Chrnb1
- Q&As
- Reviews
Q&As (5)
Ask a questionIn autoimmune myasthenia gravis, immunosuppressive therapies and acetylcholinesterase inhibitors are commonly used to manage symptoms, and some treatments specifically target the immune response against MUSK.
Yes, genetic testing and other diagnostic measures can identify MUSK protein abnormalities early in life, enabling prompt intervention and management.
Yes, diagnostic tests such as genetic testing and antibody assays can be employed to identify MUSK-related disorders.
MUSK protein plays a role in signaling pathways that contribute to muscle regeneration, making it an important factor in tissue repair.
Yes, gene therapy approaches aimed at restoring normal MUSK function are being explored as potential treatments for MUSK-related disorders.
Customer Reviews (3)
Write a reviewThe MUSK protein's high quality, stellar technical support, and compatibility with diverse experimental approaches make it an optimal choice for meeting my research needs.
Its usage in these techniques is highly praised by scientists worldwide, attesting to its effectiveness and significance in advancing scientific knowledge and understanding.
Its ability to consistently provide accurate and reliable results makes it an invaluable tool for quantifying and detecting specific targets in biological samples.
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