MVK
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Official Full Name
mevalonate kinase
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Overview
This gene encodes the peroxisomal enzyme mevalonate kinase. Mevalonate is a key intermediate, and mevalonate kinase a key early enzyme, in isoprenoid and sterol synthesis. Mevalonate kinase deficiency caused by mutation of this gene results in mevalonic aciduria, a disease characterized psychomotor retardation, failure to thrive, hepatosplenomegaly, anemia and recurrent febrile crises. Defects in this gene also cause hyperimmunoglobulinaemia D and periodic fever syndrome, a disorder characterized by recurrent episodes of fever associated with lymphadenopathy, arthralgia, gastrointestinal dismay and skin rash. Two transcript variants that encode the same protein have been found for this gene. -
Synonyms
MVK; mevalonate kinase; mevalonate kinase (mevalonic aciduria); LH receptor mRNA binding protein; LRBP; mevalonic aciduria; MK; mevalonate kinase 1; LH receptor mRNA-binding protein; MVLK; FLJ96772;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect Cell
- Insect Cells
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Strep
- Myc
- DDK
- Myc|DDK
- N/A
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
MVK involved in several pathways and played different roles in them. We selected most pathways MVK participated on our site, such as Terpenoid backbone biosynthesis, Metabolic pathways, Peroxisome, which may be useful for your reference. Also, other proteins which involved in the same pathway with MVK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Terpenoid backbone biosynthesis | MVK;PCYOX1;HMGCS1;HMGCS2;PDSS1;NUS1;FNTB;MVDA;IDI2 |
| Metabolic pathways | MTHFR;CYP19A1B;ADH6;MOGS;AGL;UCK2B;PYCR1A;ATP5IA;MGAT3 |
| Peroxisome | DAO.2;PEX26;ACSL5;PMVK;ACSL3B;DAO.3;PEX13;CRATB;NUDT7 |
MVK has several biochemical functions, for example, ATP binding, identical protein binding, mevalonate kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MVK itself. We selected most functions MVK had, and list some proteins which have the same functions with MVK. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | MAPK4;NME7;ATP13A3;AARS2;GALK1;DDX20;SMARCA2;MAPK10;WEE1 |
| identical protein binding | MUL1;LDHB;PKD2L1;GOT2A;MICU1;PARP1;SH3GL3;MVK;COL18A1 |
| mevalonate kinase activity | |
| protein binding | MDM2;CCNB3;SLC3A2;COBL;RBFA;TOMM7;HSPBAP1;HMGN2;SOX9 |
MVK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MVK here. Most of them are supplied by our site. Hope this information will be useful for your research of MVK.
POT1; TERF1; EWSR1
- Q&As
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