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MXD1

  • Official Full Name

    MAX dimerization protein 1

  • Overview

    This gene encodes a member of the MYC/MAX/MAD network of basic helix-loop-helix leucine zipper transcription factors. The MYC/MAX/MAD transcription factors mediate cellular proliferation, differentiation and apoptosis. The encoded protein antagonizes MYC-mediated transcriptional activation of target genes by competing for the binding partner MAX and recruiting repressor complexes containing histone deacetylases. Mutations in this gene may play a role in acute leukemia, and the encoded protein is a potential tumor suppressor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
  • Synonyms

    MXD1; MAX dimerization protein 1; MAD; bHLHc58; MAD1; max dimerizer 1; MAX-binding protein; antagonizer of myc transcriptional activity; MGC104659;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|Myc
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MXD1-2502H Active Recombinant Human MAX Dimerization Protein 1 E.coli N/A
Human MXD1-28856TH Recombinant Human MXD1, FLAG-tagged E.coli Flag
Human MXD1-427HCL Recombinant Human MXD1 lysate HEK293 N/A
Human MXD1-5773H Recombinant Human MXD1 Protein, GST-tagged Wheat Germ GST
Human MXD1-301546H Recombinant Human MXD1 protein, GST-tagged E.coli GST Asp170-Leu221
Human MXD1-6631HF Recombinant Full Length Human MXD1 Protein, GST-tagged In Vitro Cell Free System GST 221 amino acids
Mouse MXD1-2778M Recombinant Mouse MXD1 Protein (1-227 aa), His-Myc-tagged Insect Cell His/Myc 1-227 aa
Rhesus Macaque MXD1-2913R Recombinant Rhesus monkey MXD1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque MXD1-2732R Recombinant Rhesus Macaque MXD1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque MXD1-2732R-B Recombinant Rhesus Macaque MXD1 Protein Pre-coupled Magnetic Beads HEK293
Chicken MXD1-3369C Recombinant Chicken MXD1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

MXD1 involved in several pathways and played different roles in them. We selected most pathways MXD1 participated on our site, such as Regulation of Telomerase, Signaling events mediated by HDAC Class I, which may be useful for your reference. Also, other proteins which involved in the same pathway with MXD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Regulation of TelomeraseTNKS;CMTM2A;MXD1;NR2F2;SP3;DKC1;PINX1
Signaling events mediated by HDAC Class ISIRT5;SIRT2;FKBP3;SIRT4;TFCP2;PRMT5;NR2C1;MXD1;GATA2

MXD1 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, protein binding, protein dimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MXD1 itself. We selected most functions MXD1 had, and list some proteins which have the same functions with MXD1. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II core promoter proximal region sequence-specific DNA bindingMYBL1;PYDC3;FOSB;NKX6-1;CREB1;YBX1;TBP;BATF;IRF1
protein bindingPLA2G16;SMG5;KLF12;LNX2B;TNFRSF1B;MYO5A;ZBTB7C;NIP7;C14orf159
protein dimerization activityPTF1A;AHRRB;FBXW11B;MEF2D;HER8A;MESPBA;HER7;FAP;ZBED1
transcription cofactor activityZNF710A;PRKCBP1L;ZFP865;ZFP710;SND1;ZNF671;ZFP667;MED12;ZNF763
transcription corepressor activityCCAR1;TDP2;EID1;BHLHE40;ZNF136;E2F6;HIF3A;TFCP2L1;TAF9B
transcription factor activity, sequence-specific DNA bindingZNF711;ZNF621;TP63;ZNF239;ESR2A;TARDBP;GRHL2A;ZHX3;HINFP
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific bindingSPI1;NFIL3-5;RELA;BTG2;NKX3-2;TBX3;ASCL1;PROX1B;ZFPM1

MXD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MXD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MXD1.

SIN3B; MAX; MLX

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