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MYCN

Official Full Name

v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
Overview

This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. [provided by RefSeq, Jul 2008]
Synonyms

MYCN; v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog; NMYC; ODED; MODED; N-myc; MYCNOT; bHLHe37; N-myc proto-oncogene protein; pp65/67; oncogene NMYC; neuroblastoma MYC oncogene; class E basic helix-loop-helix protein 37; neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rat
Zebrafish

Source

E.coli
HEK293
In Vitro Cell Free System
Insect Cell
Mammalian Cell
Sf9 insect cells
Wheat Germ
Yeast

Tag

GST
His
His (Fc)
Avi
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	MYCN-27993TH	Recombinant Human MYCN protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	MYCN-30409TH	Recombinant Human MYCN	Wheat Germ	N/A	100 amino acids	Inquiry
Human	MYCN-4036HCL	Recombinant Human MYCN 293 Cell Lysate	HEK293	N/A		Inquiry
Human	MYCN-1468H	Recombinant Human MYCN Protein (1-464 aa), His-tagged	Yeast	His	1-464 aa	Inquiry
Human	MYCN-3128H	Recombinant Human MYCN protein, His-tagged	E.coli	His	289 - 464 aa	$319 / 25ug
Human	MYCN-2244H	Recombinant Human MYCN protein, His-tagged	Insect Cell	His	1-464aa	Inquiry
Human	MYCN-7006HF	Recombinant Full Length Human MYCN Protein, GST-tagged	In Vitro Cell Free System	GST	464 amino acids	Inquiry
Human	MYCN-35H	Recombinant Human MYCN Protein (Full length), N-GST-tagged	Sf9 insect cells	N-GST	Full Length	Inquiry
Mouse	MYCN-10290M	Recombinant Mouse MYCN Protein	Mammalian Cell	His		Inquiry
Mouse	MYCN-5832M-B	Recombinant Mouse MYCN Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	MYCN-5832M	Recombinant Mouse MYCN Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	MYCN-3841R	Recombinant Rat MYCN Protein	Mammalian Cell	His		Inquiry
Rat	MYCN-3500R	Recombinant Rat MYCN Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	MYCN-3500R-B	Recombinant Rat MYCN Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	MYCN-11893Z	Recombinant Zebrafish MYCN	Mammalian Cell	His		Inquiry
Chicken	MYCN-2766C	Recombinant Chicken MYCN	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
MYCN Related Articles
MYCN Related Research Area

MYCN involved in several pathways and played different roles in them. We selected most pathways MYCN participated on our site, such as Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with MYCN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Transcriptional misregulation in cancer	GOLPH3;PLAU;ATM;RELA;TSPAN7;WHSC1;FEV;MYCN;NR4A3

MYCN has several biochemical functions, for example, DNA binding, protein binding, protein dimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MYCN itself. We selected most functions MYCN had, and list some proteins which have the same functions with MYCN. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	ZFP523;RTEL1;MYO18A;RXRAA;ZNF483;ZFP39;SIX2B;TBX5;ZNF672
protein binding	TNNI1;CCDC60;FAM114A1;FAM167A;DRD2;GNAQ;VPS54;EFNB2;HIST2H3C
protein dimerization activity	AHRR;POLR2J;GRIN2A;NPAS4;PPP3CB;DAO;ID2B;LMLN;STK3
transcription factor activity, sequence-specific DNA binding	SOX13;ZNF621;GTF2IRD1;SMAD5;HOXD10;NR1D2B;TA;GM239;NR6A1A

MYCN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MYCN here. Most of them are supplied by our site. Hope this information will be useful for your research of MYCN.

AURKA; MAX; Aurka; CDKN2A; SIRT1

Ramani, P; Nash, R; et al. Aurora kinase A is superior to Ki67 as a prognostic indicator of survival in neuroblastoma. HISTOPATHOLOGY 66:370-379(2015).

Wang, L; Wu, JZ; et al. Regulation of the cell cycle and PI3K/Akt/mTOR signaling pathway by tanshinone I in human breast cancer cell lines. MOLECULAR MEDICINE REPORTS 11:931-939(2015).

Oncoprotein-Transcription Factors