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MYD88

  • Official Full Name

    myeloid differentiation primary response 88

  • Overview

    This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
  • Synonyms

    MYD88; myeloid differentiation primary response 88; MYD88D; myeloid differentiation primary response protein MyD88; myeloid differentiation primary response gene (88);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • Myc
  • DDK
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • MYC
  • Myc|DDK
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MYD88-29151TH Recombinant Human MYD88 Wheat Germ N/A 100 amino acids
Human MYD88-7112H Recombinant Human MYD88, His-tagged E.coli His 1-309aa
Human MYD88-1550H Recombinant Human Myeloid Differentiation Primary Response Gene (88) E.coli N/A
Human MYD88-30H Recombinant Human MYD88 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human MYD88-4034HCL Recombinant Human MYD88 293 Cell Lysate HEK293 N/A
Human MYD88-4760H Recombinant Human MYD88 protein, His-tagged E.coli His 1-296aa
Human MYD88-1462H Recombinant Human MYD88 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human MYD88-5796H Recombinant Human MYD88 Protein, GST-tagged Wheat Germ GST
Human MYD88-301137H Recombinant Human MYD88 protein, GST-tagged E.coli GST Met1-Leu150
Human MYD88-687HFL Recombinant Full Length Human MYD88 Protein, C-Flag-tagged Mammalian cells Flag
Human MYD88-0071H Recombinant Human MYD88 Protein (M157-P296), Tag Free E.coli No tag M157-P296
Human MYD88-6731HF Recombinant Full Length Human MYD88 Protein, GST-tagged In Vitro Cell Free System GST 296 amino acids
Human MYD88-0072H Recombinant Human MYD88 Protein (M157-P296), His/GST tagged E.coli His/GST M157-P296
Human MYD88-1462H-B Recombinant Human MYD88 Protein Pre-coupled Magnetic Beads HEK293
Human MYD88-4640H Recombinant Human MYD88 Protein (Met157-Pro296), N-His tagged E.coli N-His Met157-Pro296
Human MYD88-272H Recombinant Human MYD88 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Mouse Myd88-1827M Recombinant Mouse Myd88 protein, His-tagged E.coli His Arg32~Pro265 (Accession # P22366)
Mouse MYD88-10293M Recombinant Mouse MYD88 Protein Mammalian Cell His
Mouse MYD88-5835M-B Recombinant Mouse MYD88 Protein Pre-coupled Magnetic Beads HEK293
Mouse Myd88-001M Recombinant Mouse Myd88 Protein, MYC/DDK-tagged HEK293 MYC/DDK
Mouse Myd88-4241M Recombinant Mouse Myd88 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse MYD88-5835M Recombinant Mouse MYD88 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Myd88-1828R Recombinant Rat Myd88 protein, His & GST-tagged E.coli His/GST Met1~Pro296 (Accession # Q6Y1S1)
Rat MYD88-3843R Recombinant Rat MYD88 Protein Mammalian Cell His
Rat MYD88-3502R Recombinant Rat MYD88 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat MYD88-3502R-B Recombinant Rat MYD88 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque MYD88-2918R Recombinant Rhesus monkey MYD88 Protein, His-tagged Mammalian Cell His
Rhesus Macaque MYD88-2737R Recombinant Rhesus Macaque MYD88 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque MYD88-2737R-B Recombinant Rhesus Macaque MYD88 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish MYD88-12080Z Recombinant Zebrafish MYD88 Mammalian Cell His
Chicken MYD88-2650C Recombinant Chicken MYD88 Mammalian Cell His
Chicken MYD88-1147C Recombinant Chicken MYD88 Protein, His-tagged E.coli N-His Arg34-Pro299
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MYD88 Related Articles
  • MYD88 Related Research Area

MYD88 involved in several pathways and played different roles in them. We selected most pathways MYD88 participated on our site, such as NF-kappa B signaling pathway, Apoptosis, Toll-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MYD88 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
NF-kappa B signaling pathwayCCL4;LCK;CXCL2;ATM;CCL21B;ERC1;LBP;NFKB1;LRDD
ApoptosisDFFA;PPP3CCB;HIST1H1B;CDK5RAP2;PIK3R5;PPP3CA;DCC;PRKACA;CAPN2
Toll-like receptor signaling pathwayRELA;Ifna11;CD86;PIK3R2;CXCL9;NFKBIAA;CCL4L1;PIK3CG;IKBKG
Salmonella infectionDYNC1LI2;PFN2L;ROCK2B;NFKB1;DYNC1I1;FLNB;TLR4BA;KLC2;TLR5B
PertussisMAPK10;GNAI2;CALML3;Il23a; Il12b;IRAK4;MAPK13;CALM2;CASP1;SERPING1
LegionellosisNAIP6;VCP;HSPD1;TNF;IL6;CXCL3;TLR4;CASP7;RAB1A
LeishmaniasisNCF1;TLR2;NCF2;HLA-DRA;Itgam&Itgb2;TGFB1;PRKCB;HLA-DQB1;TNF
Chagas disease (American trypanosomiasis)LOC100033925;TLR9;C1QC;GNA11;ACE;PLCB4;PPP2R2C;PPP2R2A;SMAD3
African trypanosomiasisICAM1;PLCB1;IFNG;IDO2;IL6;PLCB3;Fasl;PRKCA;IL18
MalariaIL-8;TGFB1;THBS4;COMP;CD40LG;THBS2;Ccl12;TGFB3;TGFB2
ToxoplasmosisTAB2;HLA-DPA1;Casp3;LAMC2;ITGB1;HLA-DRB1;TLR2;BIRC2;LAMB2
TuberculosisRFX5;RIPK2;BID;LSP1;HLA-DRA;PLK3;CAMK2B;TRADD;CARD9
Hepatitis BMAPK1;RB1;PTK2B;MAP2K4;STAT2;AKT2;BAX;TGFB3;PIK3R3
MeaslesAKT1;TNFRSF10A;TLR2;IFNAR2;PIK3R2;IL12A;IFNGR2;DOK1;OAS3
Influenza AHLA-DPA1;IKBKE;PABPN1;DNAJB1;IFNB1;ADAR;IFNA16;XPO1;PML
Herpes simplex infectionCRFB2;HLA-DOA;IFNPHI3;HLA-DPB1;HLA-DMB;TAB2;HCFC1;EIF2S1B;IRF3

MYD88 has several biochemical functions, for example, TIR domain binding, death receptor binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MYD88 itself. We selected most functions MYD88 had, and list some proteins which have the same functions with MYD88. You can find most of the proteins on our site.

Function Related Protein
TIR domain binding
death receptor bindingFEM1B;PRDM4;NOL3;PIDD1;FADD;TMBIM1;MYD88;RIPK1;TNFSF15
identical protein bindingSEPHS1;AXIN1;CALCA;TNK2;GRASP;SH3GLB1;RGMB;TPCN2;COL2A1
protein bindingPLIN3;SFRS9;RPS6KA2;POLM;HIST1H2BE;BPIFA2;RTN3;SPTSSA;TOB1

MYD88 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MYD88 here. Most of them are supplied by our site. Hope this information will be useful for your research of MYD88.

TIRAP; SPOP; TNFRSF13B

Maeda, A; Bandow, K; et al. Induction of CXCL2 and CCL2 by pressure force requires IL-1 beta-MyD88 axis in osteoblasts. BONE 74:76-82(2015).
Huang, HF; Zeng, Z; et al. Heme oxygenase-1 protects rat liver against warm ischemia/reperfusion injury via TLR2/TLR4-triggered signaling pathways. WORLD JOURNAL OF GASTROENTEROLOGY 21:2937-2948(2015).
  • Q&As
  • Reviews

Q&As (5)

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How does MYD88 contribute to the formation of the Myddosome complex in TLR signaling? 12/13/2021

MYD88 recruits IRAK kinases to form the Myddosome complex, initiating a signaling cascade that culminates in the activation of NF-κB and pro-inflammatory gene expression.

How is the expression of the MYD88 gene regulated at the molecular level? 06/26/2020

MYD88 expression is tightly regulated at the transcriptional level by various factors, including transcription factors and epigenetic modifications.

Explain the role of MYD88 in the recognition of microbial components by the immune system. 03/09/2019

MYD88 is a key mediator in the recognition of microbial components by TLRs, initiating signaling cascades that trigger immune responses against pathogens.

What are the downstream signaling pathways activated by MYD88, and how do they influence immune responses? 10/26/2018

MYD88 activates NF-κB and MAPK signaling pathways, leading to the production of pro-inflammatory cytokines and interferons that orchestrate immune responses.

Explain the role of MYD88 in adaptive immunity and its crosstalk with T and B cell responses. 05/01/2018

MYD88 plays a role in shaping adaptive immune responses by influencing the activation and differentiation of T and B cells, promoting an effective immune defense.

Customer Reviews (3)

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Reviews
02/26/2022

    Top-tier service—customer support's expertise ensured the perfect protein fit.

    01/09/2019

      Dependable quality and service—this recombined protein is a lab favorite.

      05/23/2018

        Rapid delivery, precise results—this product is a lab essential.

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