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MYO3A

Official Full Name

myosin IIIA
Overview

The protein encoded by this gene belongs to the myosin superfamily. Myosins are actin-dependent motor proteins and are categorized into conventional myosins (class II) and unconventional myosins (classes I and III through XV) based on their variable C-terminal cargo-binding domains. Class III myosins, such as this one, have a kinase domain N-terminal to the conserved N-terminal motor domains and are expressed in photoreceptors. The protein encoded by this gene plays an important role in hearing in humans. Three different recessive, loss of function mutations in the encoded protein have been shown to cause nonsyndromic progressive hearing loss. Expression of this gene is highly restricted, with the strongest expression in retina and cochlea.
Synonyms

MYO3A; myosin IIIA; deafness, autosomal recessive 30 , DFNB30; myosin-IIIa; deafness, autosomal recessive 30; DFNB30;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Human
Zebrafish

Source

E.coli
In Vitro Cell Free System
Mammalian Cell
Sf9 Insect Cell
Wheat Germ

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	MYO3A-90H	Active Recombinant Human MYO3A, GST-tagged	Sf9 Insect Cell	GST		Inquiry
Human	MYO3A-1160HCL	Recombinant Human MYO3A cell lysate		N/A		Inquiry
Human	MYO3A-5838H	Recombinant Human MYO3A Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	MYO3A-6774HF	Recombinant Full Length Human MYO3A Protein, GST-tagged	In Vitro Cell Free System	GST	247 amino acids	Inquiry
Human	MYO3A-301341H	Recombinant Human MYO3A protein, GST-tagged	E.coli	GST	Gln1090-Ser1308	Inquiry
Zebrafish	MYO3A-11619Z	Recombinant Zebrafish MYO3A	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

MYO3A involved in several pathways and played different roles in them. We selected most pathways MYO3A participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MYO3A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

MYO3A has several biochemical functions, for example, ADP binding, ATP binding, actin filament binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MYO3A itself. We selected most functions MYO3A had, and list some proteins which have the same functions with MYO3A. You can find most of the proteins on our site.

Function	Related Protein
ADP binding	GCLC;MYH10;CYB5R3;P2RY1;ME1;ERN1;PRPS1;PKM;MIEF1
ATP binding	TAP2;MLH1;SNRK;CHEK1;PRKCZ;UBE2D3;DDX11;STRADA;MCM2
actin filament binding	SHROOM1;PANX1;WIPF1A;SVILA;VPS16;MARCKS;NEBL;MYO7A;MYH11A
actin-dependent ATPase activity	MYH9;MYO1C;MYO1D;MYL6;MYH10;MYH7;MYO7A;MYO3A
calmodulin binding	IQCB1;NRGNA;MYH1;C2orf62;MARCKSA;MYO1A;CNN1A;MYO3A;MYO7A
microfilament motor activity	MYH3;MYH13;MYH8;MYO5A;MYH7;MYH10;MYH9;MYO1D;MYO7A
plus-end directed microfilament motor activity	MYO3A;MYO19
protein kinase activity	MAP3K11;PKDCC;AKT3;DAPK1;RIPK1;PDPK1B;TSSK1;SNRKA;PTK2
protein serine/threonine kinase activity	SYK;BMPR2B;CSNK1DA;TTBK2;STK10;CSNK1G2;RAF1B;MAP3K8;TESK2

MYO3A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MYO3A here. Most of them are supplied by our site. Hope this information will be useful for your research of MYO3A.

GRINL1A