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ST14

  • Official Full Name

    suppression of tumorigenicity 14 (colon carcinoma)

  • Overview

    The protein encoded by this gene is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis. [provided by RefSeq, Jul 2008]
  • Synonyms

    ST14; suppression of tumorigenicity 14 (colon carcinoma); HAI; MTSP1; SNC19; ARCI11; MT-SP1; PRSS14; TADG15; TMPRSS14; suppressor of tumorigenicity 14 protein; prostamin; serine protease 14; serine protease TADG-15; membrane-type serine protease 1; tumor associated differentially expressed gene 15 protein; tumor-associated differentially-expressed gene 15 protein; suppression of tumorigenicity 14 (colon carcinoma, matriptase, epithin);

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • His
  • His (Fc)
  • Avi
  • Met|His
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ST14-742H Active Recombinant Human ST14 Protein, Met & His-tagged E.coli Met/His Gly596-Val855
Human ST14-256H Active Recombinant Human ST14, His-tagged E.coli His
Human ST14-2977H Recombinant Human ST14, His-tagged E.coli His 1-300aa
Human ST14-30315TH Recombinant Human ST14 Wheat Germ N/A 103 amino acids
Human ST14-31173TH Recombinant Human ST14 Wheat Germ N/A 855 amino acids
Human ST14-03H Active Recombinant Human ST14 Protein, His-tagged His
Human ST14-500HF Recombinant Full Length Human ST14 Protein In Vitro Cell Free System 855 amino acids
Mouse St14-210M Active Recombinant Mouse St14, His-tagged E.coli His
Mouse St14-653M Active Recombinant Mouse St14 Protein, Met & His-tagged E.coli Met/His Gly596-Val855
Mouse ST14-16060M Recombinant Mouse ST14 Protein Mammalian Cell His
Mouse ST14-8757M-B Recombinant Mouse ST14 Protein Pre-coupled Magnetic Beads HEK293
Mouse ST14-8757M Recombinant Mouse ST14 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ST14 Related Research Area

ST14 involved in several pathways and played different roles in them. We selected most pathways ST14 participated on our site, such as MicroRNAs in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with ST14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MicroRNAs in cancerSTMN1;HMGA2;MARCKS;CCNE2;HMOX1;BMI1;MAP2K1;DNMT3A;MMP16

ST14 has several biochemical functions, for example, serine-type endopeptidase activity, serine-type peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ST14 itself. We selected most functions ST14 had, and list some proteins which have the same functions with ST14. You can find most of the proteins on our site.

Function Related Protein
serine-type endopeptidase activityCMA1;KLK13;KLK7;KLK5;PCSK9;TPP1;PRSS2;PRSS37;CELA2B
serine-type peptidase activityKLK4;KLK1B1;KLK1B5;MCPT1;MCPT9;PRSS44;HTRA1B;IRBP;KLK1B3

ST14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ST14 here. Most of them are supplied by our site. Hope this information will be useful for your research of ST14.

bpt1_bovin; MST1; IGFBP7; RGS16; CHEK2; TGFB1; APC; AKT1; PHB; CDKN2C; NOTCH2; RAD51; CASP8; STK11

  • Q&As
  • Reviews

Q&As (7)

Ask a question
How does ST14 contribute to the regulation of protease activity? 06/12/2022

It regulates proteolytic activity, contributing to cellular processes like proliferation, differentiation, and migration.

In which cells or tissues is ST14 predominantly expressed? 04/04/2022

ST14 is predominantly expressed in epithelial tissues and is also found in immune cells.

Are there known genetic mutations or alterations in ST14 associated with specific diseases? 03/12/2022

Mutations and altered expression of ST14 have been associated with various types of cancers.

What role does ST14 play in the epidermal growth factor receptor (EGFR) signaling pathway? 01/27/2022

ST14 activates the EGFR pathway by cleaving and activating pro-heparin-binding EGF-like growth factor (pro-HB-EGF).

What therapeutic strategies are being explored targeting ST14 for disease treatment? 12/14/2020

Therapeutic strategies include developing ST14 inhibitors to prevent its pro-tumorigenic activities in cancer.

How is ST14 implicated in cancer progression and metastasis? 05/16/2020

Overexpression of ST14 is linked to cancer progression, enhancing tumor cell invasion and metastasis.

What is the primary function of the ST14 protein in cellular processes? 04/28/2020

ST14 (matriptase) is a type II transmembrane serine protease involved in the activation of other proteases and growth factors.

Customer Reviews (3)

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Reviews
04/08/2022

    Worked well in research.

    07/14/2021

      Great product, excellent quality.

      02/10/2021

        Reliable, high-quality product.

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