MBL2
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Official Full Name
mannose-binding lectin (protein C) 2, soluble
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Overview
Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA. -
Synonyms
COLEC 1; COLEC1; Collectin-1; HSMBPC; Mannan binding lectin; Mannan binding protein; Mannan-binding protein; Mannose binding lectin (protein C)3soluble; Mannose binding lectin (protein C) 2, soluble (opsonic defect); Mannose binding lectin (protein C) 2, soluble; Mannose binding lectin3soluble; Mannose binding lectin 2, soluble (opsonic defect); Mannose binding lectin; Mannose binding lectin protein C2 soluble opsonic defect; Mannose binding protein; Mannose binding protein C; Mannose binding protein C precursor; Mannose-binding lectin; Mannose-binding protein C; MBL 2; MBL; MBL2; MBL2_HUMAN; MBL2D; MBP 1; MBP; MBP C; MBP-C; MBP1; MBPC; MGC116832; MGC116833; Opsonic defect; protein C; Soluble mannose binding lectin;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Bovine
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- Baculovirus-Insect cells
- CHO
- E. coli
- E.coli
- HEK293
- HEK293F
- HEK293T
- Human Cell
- Insect Cells
- Mammalian Cell
- Mammalian cells
- Yeast
- C
- His
- Fc
- His (Fc)
- Avi
- His|GST
- His|MBP
- His|T7
- Myc
- DDK
- Myc|DDK
- N/A
- N
- GST
- Tag Free
- Involved Pathway
- Protein Function
- Interacting Protein
- MBL2 Related Articles
- MBL2 Related Research Area
MBL2 involved in several pathways and played different roles in them. We selected most pathways MBL2 participated on our site, such as Phagosome, Complement and coagulation cascades, Staphylococcus aureus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with MBL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Phagosome | Ctsl;CD209B;BF2;ATP6V0D1;STX18;TUBB5;HLA-DRB3;ATP6V0E;TUBAL3 |
Complement and coagulation cascades | F8;CR1L;C1R;CR2;VWF;F10;C4A;LOC100514666;PLG |
Staphylococcus aureus infection | CFI;HLA-DMA;HLA-DRB3;FCGR3A;PLG;HLA-DRB4;Hc;DSG1A;SELP |
MBL2 has several biochemical functions, for example, calcium ion binding, calcium-dependent protein binding, mannose binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MBL2 itself. We selected most functions MBL2 had, and list some proteins which have the same functions with MBL2. You can find most of the proteins on our site.
Function | Related Protein |
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calcium ion binding | EFEMP2A;SYT5B;TBC1D9B;MMP1A;PCDH2AB9;PCDHB16;TNNC2;CDH17;CAPN2A |
calcium-dependent protein binding | S100A1;S100A4;PLSCR3;STX2;NELF;ANXA3;CPNE3;MMP13;VPS37C |
mannose binding | CD209C;MBL1;CLEC4M;LMAN2L;MANBA;DPM1;LMAN1;CD209A;Acr |
protein binding | VPS72;GMIP;TPM4;ALOX5;TNIP3;VPS45;GAS6;TRIM5;ZFP932 |
receptor binding | PLXNC1;MCHR1;PVRL1B;NRG2;JAK2;Fert2;HLA-B;KCNA5;IDE |
MBL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MBL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MBL2.
LRP1; TLR3; YBX1
- Q&As
- Reviews
Q&As (5)
Ask a questionMBL2 binds to the surface of pathogens, triggering the activation of the complement system, which leads to the destruction of the pathogens.
Yes, altered levels of MBL2 in the blood can serve as a biomarker for certain infections and immune-related disorders.
Yes, MBL2 deficiencies have been linked to an increased susceptibility to various infections and autoimmune diseases.
Yes, genetic variations in the MBL2 gene can lead to variations in MBL2 protein levels and functionality.
Yes, targeting MBL2 in drug development may offer new avenues for modulating the immune response and treating infectious and autoimmune diseases.
Customer Reviews (3)
Write a reviewThe use of MBL2 protein in such analyses provides valuable structural insights that contribute to the elucidation of ANO2's functional mechanisms and potential drug targeting sites.
MBL2 protein has shown great utility in protein electron microscopy structure analysis.
By visualizing the structural features, interactions, and conformational changes of MBL2, researchers gain valuable insights into its function and potential for therapeutic interventions.
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