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MBL2

  • Official Full Name

    mannose-binding lectin (protein C) 2, soluble

  • Overview

    Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA.
  • Synonyms

    COLEC 1; COLEC1; Collectin-1; HSMBPC; Mannan binding lectin; Mannan binding protein; Mannan-binding protein; Mannose binding lectin (protein C)3soluble; Mannose binding lectin (protein C) 2, soluble (opsonic defect); Mannose binding lectin (protein C) 2, soluble; Mannose binding lectin3soluble; Mannose binding lectin 2, soluble (opsonic defect); Mannose binding lectin; Mannose binding lectin protein C2 soluble opsonic defect; Mannose binding protein; Mannose binding protein C; Mannose binding protein C precursor; Mannose-binding lectin; Mannose-binding protein C; MBL 2; MBL; MBL2; MBL2_HUMAN; MBL2D; MBP 1; MBP; MBP C; MBP-C; MBP1; MBPC; MGC116832; MGC116833; Opsonic defect; protein C; Soluble mannose binding lectin;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bovine
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Baculovirus-Insect cells
  • CHO
  • E. coli
  • E.coli
  • HEK293
  • HEK293F
  • HEK293T
  • Human Cell
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • Yeast
  • C
  • His
  • Fc
  • His (Fc)
  • Avi
  • His|GST
  • His|MBP
  • His|T7
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • GST
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MBL2-354H Active Recombinant Human MBL2 Mammalian cells N/A
Human MBL2-7019H Recombinant Human MBL2 protein, His & MBP-tagged E.coli His/MBP Leu130~Ile248
Human MBL2-233H Recombinant Human MBL2 protein, His-tagged HEK293 His Glu21-Ile248
Human MBL2-373H Recombinant Human mannose-binding lectin (protein C) 2, soluble, His-tagged E.coli His
Human MBL2-2329H Recombinant Human MBL2, His tagged Human Cell His
Human MBL2-2330H Recombinant Human MBL2 protein CHO N/A Met1-Ile 248
Human MBL2-575H Recombinant Human MBL2 protein, His & GST-tagged E.coli His/GST Leu130~Ile248
Human MBL2-001HCL Recombinant Human MBL2 cell lysate CHO N/A
Human MBL2-1453H Recombinant Human MBL2 Protein (21-248 aa), His-tagged Yeast His 21-248 aa
Human MBL2-377H Recombinant Human MBL2 Protein, His-tagged HEK293 His 248
Human MBL2-620H Recombinant Human MBL2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human MBL2-4449H-B Recombinant Human MBL2 Protein Pre-coupled Magnetic Beads HEK293
Human MBL2-1098H Recombinant Human MBL2 Protein, His-tagged HEK293F N-His Leu130-Ile248
Human MBL2-4509H Recombinant Human MBL2 Protein (Glu21-Ile248), C-His tagged Mammalian cells C-His Glu21-Ile248
Human MBL2-4511H Recombinant Human MBL2 Protein (Glu21-Ile248), N-His tagged E.coli N-His Glu21-Ile248
Human MBL2-4449H Recombinant Human MBL2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human MBL2-2636H Recombinant Human MBL2 protein(21-248 aa), C-His-tagged E. coli C-His 21-248 aa
Mouse Mbl2-834M Recombinant Mouse Mbl2 Protein, Fc-tagged HEK293 Fc
Mouse Mbl2-835M Recombinant Mouse Mbl2 Protein, His-tagged HEK293 His
Mouse Mbl2-7020M Recombinant Mouse Mbl2 protein, His & T7-tagged E.coli His/T7 Glu19~Asp244 (Accession # P41317)
Mouse Mbl2-0144M Recombinant Mouse Mbl2 Protein (Full Length), C-His-tagged Baculovirus-Insect cells C-His Full Length
Mouse Mbl2-3980M Recombinant Mouse Mbl2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Mbl2-6752M Recombinant Mouse Mbl2 Protein (Glu19-Asp244) Mammalian cells Tag Free Glu19-Asp244
Mouse Mbl2-4062M Recombinant Mouse Mbl2 Protein (Ala18-Asp244), C-His tagged Insect Cells C-His Ala18-Asp244
Mouse Mbl2-4928M Recombinant Mouse Mbl2 protein(19-244aa), His-tagged E. coli N-His 19-244aa
Rat Mbl2-7022R Recombinant Rat Mbl2 protein, His & GST-tagged E.coli His/GST Glu19~Asp244 (Accession # P08661)
Rat MBL2-3603R Recombinant Rat MBL2 Protein Mammalian Cell His
Rat Mbl2-7021R Recombinant Rat Mbl2 protein, His-tagged E.coli His Glu19~Asp244
Rat MBL2-3259R-B Recombinant Rat MBL2 Protein Pre-coupled Magnetic Beads HEK293
Rat MBL2-3259R Recombinant Rat MBL2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Mbl2-4922R Recombinant Rat Mbl2 protein(19-244aa), GST-tagged E. coli N-GST 19-244aa
Bovine MBL2-1452B Recombinant Bovine MBL2 Protein (21-249 aa), His-tagged Yeast His 21-249 aa
Rhesus Macaque MBL2-2694R Recombinant Rhesus monkey MBL2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque MBL2-2514R-B Recombinant Rhesus Macaque MBL2 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque MBL2-2514R Recombinant Rhesus Macaque MBL2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken MBL2-5921C Recombinant Chicken MBL2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MBL2 Related Articles
  • MBL2 Related Research Area

MBL2 involved in several pathways and played different roles in them. We selected most pathways MBL2 participated on our site, such as Phagosome, Complement and coagulation cascades, Staphylococcus aureus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with MBL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
PhagosomeCtsl;CD209B;BF2;ATP6V0D1;STX18;TUBB5;HLA-DRB3;ATP6V0E;TUBAL3
Complement and coagulation cascadesF8;CR1L;C1R;CR2;VWF;F10;C4A;LOC100514666;PLG
Staphylococcus aureus infectionCFI;HLA-DMA;HLA-DRB3;FCGR3A;PLG;HLA-DRB4;Hc;DSG1A;SELP

MBL2 has several biochemical functions, for example, calcium ion binding, calcium-dependent protein binding, mannose binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MBL2 itself. We selected most functions MBL2 had, and list some proteins which have the same functions with MBL2. You can find most of the proteins on our site.

Function Related Protein
calcium ion bindingEFEMP2A;SYT5B;TBC1D9B;MMP1A;PCDH2AB9;PCDHB16;TNNC2;CDH17;CAPN2A
calcium-dependent protein bindingS100A1;S100A4;PLSCR3;STX2;NELF;ANXA3;CPNE3;MMP13;VPS37C
mannose bindingCD209C;MBL1;CLEC4M;LMAN2L;MANBA;DPM1;LMAN1;CD209A;Acr
protein bindingVPS72;GMIP;TPM4;ALOX5;TNIP3;VPS45;GAS6;TRIM5;ZFP932
receptor bindingPLXNC1;MCHR1;PVRL1B;NRG2;JAK2;Fert2;HLA-B;KCNA5;IDE

MBL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MBL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MBL2.

LRP1; TLR3; YBX1

Pavlov, VI; Tan, YS; et al. Human Mannose-Binding Lectin Inhibitor Prevents Myocardial Injury and Arterial Thrombogenesis in a Novel Animal Model. AMERICAN JOURNAL OF PATHOLOGY 185:347-355(2015).
Soltani, A; RahmatiRad, S; et al. Polymorphisms and Serum Level of Mannose-Binding Lectin: An Iranian Survey. IRANIAN JOURNAL OF ALLERGY ASTHMA AND IMMUNOLOGY 13:428-432(2014).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
How does MBL2 contribute to the defense against infections? 12/21/2022

MBL2 binds to the surface of pathogens, triggering the activation of the complement system, which leads to the destruction of the pathogens.

Can MBL2 be used as a biomarker for certain medical conditions? 07/01/2022

Yes, altered levels of MBL2 in the blood can serve as a biomarker for certain infections and immune-related disorders.

Are there any diseases associated with MBL2 deficiencies? 05/20/2018

Yes, MBL2 deficiencies have been linked to an increased susceptibility to various infections and autoimmune diseases.

Are there any genetic variations in the MBL2 gene? 06/27/2017

Yes, genetic variations in the MBL2 gene can lead to variations in MBL2 protein levels and functionality.

Can MBL2 be a target for drug development? 12/03/2016

Yes, targeting MBL2 in drug development may offer new avenues for modulating the immune response and treating infectious and autoimmune diseases.

Customer Reviews (3)

Write a review
Reviews
09/05/2019

    The use of MBL2 protein in such analyses provides valuable structural insights that contribute to the elucidation of ANO2's functional mechanisms and potential drug targeting sites.

    01/28/2018

      MBL2 protein has shown great utility in protein electron microscopy structure analysis.

      06/06/2016

        By visualizing the structural features, interactions, and conformational changes of MBL2, researchers gain valuable insights into its function and potential for therapeutic interventions.

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