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MCL1

  • Official Full Name

    myeloid cell leukemia sequence 1 (BCL2-related)

  • Overview

    MCL-1 (Myeloid cell leukemia-1) is a member of the BCL-2 family. The carboxy terminal of MCL-1 and BCL-2 share significant sequence homology. Expression of MCL-1 is increased upon exposure of ML-1 cells to various types of DNA damaging agents (e.g. ionizing radiation, ultraviolet radiation, and alkylating drugs) along with increases in GADD45 and Bax and a decrease in BCL-2. Like BCL-2, MCL-1 has the capacity to promote cell viability under conditions that otherwise cause apoptosis. This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing.
  • Synonyms

    MCL1; myeloid cell leukemia sequence 1 (BCL2-related); induced myeloid leukemia cell differentiation protein Mcl-1; BCL2L3; Mcl 1; bcl-2-like protein 3; myeloid cell leukemia ES; bcl-2-related protein EAT/mcl1; TM; EAT; MCL1L; MCL1S; Mcl-1; MCL1-ES; bcl2-L-3; mcl1/EAT; MGC1839; MGC104264; myeloid cell leukemia sequence 1, isoform 1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Canis lupus familiaris (Dog) (Canis familiaris)
  • Chicken
  • Felis catus (Cat) (Felis silvestris catus)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rhesus Macaque
  • Rhesus monkey
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • SUMO
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MCL1-781H Recombinant Human MCL1, His-tagged E.coli His 1-327aa
Human MCL1-780H Recombinant Human MCL1 protein, His-tagged E.coli His Arg6~Ile328
Human MCL1-782H Recombinant Human MCL1, GST-tagged E.coli GST 1-327aa
Human MCL1-779H Recombinant Human MCL1, His-tagged E.coli His 1-350aa
Human MCL1-4422HCL Recombinant Human MCL1 293 Cell Lysate HEK293 N/A
Human MCL135884H Recombinant Human Mcl1 (171-327) -delta(192-208) Protein
Human MCL1-4517H Recombinant Human MCL1 Protein (Arg6-Ile328), His tagged E.coli His Arg6-Ile328
Human MCL1-5820H Recombinant Human MCL1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human MCL1-337HFL Recombinant Full Length Human MCL1 Protein, C-Flag-tagged Mammalian cells Flag
Human MCL1-1381H Recombinant Human MCL1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human MCL1-1381H-B Recombinant Human MCL1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Mcl1-185M Recombinant Mouse Mcl1 protein, His-tagged E.coli His Phe2~Gly307
Mouse MCL1-9632M Recombinant Mouse MCL1 Protein Mammalian Cell His
Mouse Mcl1-780M Recombinant Mouse Mcl1, GST-tagged E.coli GST 1-331aa
Mouse Mcl1-3211M Recombinant Mouse Mcl1 protein, His-SUMO-tagged E.coli His-SUMO 1-308aa
Mouse Mcl1-3995M Recombinant Mouse Mcl1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse MCL1-5408M-B Recombinant Mouse MCL1 Protein Pre-coupled Magnetic Beads HEK293
Mouse MCL1-5408M Recombinant Mouse MCL1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat MCL1-3618R Recombinant Rat MCL1 Protein Mammalian Cell His
Rat MCL1-3274R Recombinant Rat MCL1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat MCL1-3274R-B Recombinant Rat MCL1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus monkey MCL1-73R Recombinant Rhesus monkey MCL1 Protein, His-tagged E.coli His
Canis lupus familiaris (Dog) (Canis familiaris) RFL18182CF Recombinant Full Length Dog Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 Homolog(Mcl1) Protein, His-Tagged E.coli expression system His Full Length (1-350)
Felis catus (Cat) (Felis silvestris catus) RFL36571FF Recombinant Full Length Cat Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 Homolog(Mcl1) Protein, His-Tagged E.coli expression system His Full Length (1-350)
Mus musculus (Mouse) RFL3792MF Recombinant Full Length Mouse Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 Homolog(Mcl1) Protein, His-Tagged E.coli expression system His Full Length (1-331)
Rhesus Macaque MCL1-2702R Recombinant Rhesus monkey MCL1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque MCL1-2522R Recombinant Rhesus Macaque MCL1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque MCL1-2522R-B Recombinant Rhesus Macaque MCL1 Protein Pre-coupled Magnetic Beads HEK293
Chicken MCL1-4610C Recombinant Chicken MCL1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MCL1 Related Articles
  • MCL1 Related Gene Family
  • MCL1 Related Signal Pathway

MCL1 involved in several pathways and played different roles in them. We selected most pathways MCL1 participated on our site, such as PIK-Akt signaling pathway, Jak-STAT signaling pathway, MicroRNAs in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with MCL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
PIK-Akt signaling pathwayRBL2;PDGFC;ITGA6;KITLG;INS1;COL6A6;PTK2;CREB3L2;TCL1B1
Jak-STAT signaling pathwayGRB2A;IL9;PIAS4A;Ifna15;SOCS5B;LIFRA;Il6ra;GRB2;IL4
MicroRNAs in cancerBAK1;PRKCE;TRP63;TP53;ROCK1;BMF;Casp3;CCNE2;WNT3A

MCL1 has several biochemical functions, for example, BH3 domain binding, protein binding, protein channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MCL1 itself. We selected most functions MCL1 had, and list some proteins which have the same functions with MCL1. You can find most of the proteins on our site.

Function Related Protein
BH3 domain bindingMCL1;BAX;BCL2;BCL2L1
protein bindingRSG1;ARHGAP44;RIMS1;LEO1;FZD5;WIPI2;CAV3;MUSK;ITM2A
protein channel activityTIMM22;TOMM40L;TOMM40;MCL1;TIMM23
protein heterodimerization activityATF4;HIST2H4A;POLE4;PDX1;GABRR1;AGTR1A;SLC51B;RARA;ADRa1A
protein homodimerization activityACVR1;TCF3A;DPY30;NACC2;NLRC4;CHMP4A;CAV2;XPA;ZNF174

MCL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MCL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MCL1.

BCL2L11; BAK1

Wang, YN; Bhattacharya, D; et al. Adjuvant-specific regulation of long-term antibody responses by ZBTB20. JOURNAL OF EXPERIMENTAL MEDICINE 211:841-856(2014).
Abdulghani, J; Allen, JE; et al. Sorafenib Sensitizes Solid Tumors to Apo2L/TRAIL and Apo2L/TRAIL Receptor Agonist Antibodies by the Jak2-Stat3-Mcl1 Axis. PLOS ONE 8:-(2013).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
Can targeting MCL1 have implications beyond cancer therapy? 11/22/2021

Yes, MCL1 modulation may have therapeutic implications in other diseases, such as neurodegenerative disorders, where apoptosis is a contributing factor.

Are there any diagnostic tools or biomarkers that can assess MCL1 expression in cancer patients? 08/11/2021

Immunohistochemistry and molecular assays can be used to measure MCL1 expression levels, providing insights into the prognosis and potential treatment strategies.

How does the understanding of MCL1 function contribute to personalized medicine in cancer treatment? 12/29/2019

Understanding MCL1 expression allows for the identification of patients who may benefit from targeted therapies, contributing to personalized treatment strategies.

Are there any ongoing clinical trials exploring MCL1 inhibitors as a therapeutic approach? 04/12/2019

Yes, there are several clinical trials investigating the use of MCL1 inhibitors in different cancer types to assess their safety and efficacy.

How does the MCL1 protein interact with other proteins in the Bcl-2 family? 02/08/2018

MCL1 interacts with pro-apoptotic and anti-apoptotic proteins in the Bcl-2 family, influencing the balance between cell survival and death.

Customer Reviews (3)

Write a review
Reviews
06/20/2022

    Another advantage of using MCL1 protein in trials is its potential as a therapeutic agent.

    01/16/2022

      The manufacturer's support and expertise further enhance the utility of MCL1 in my experimental work, ensuring reliable and high-quality results.

      03/23/2016

        This collaborative partnership greatly contributes to the success of my research projects and facilitates meaningful contributions to the scientific community.

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