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NBN

  • Official Full Name

    nibrin

  • Overview

    Nibrin, a ~95 kDa double stranded DNA repair protein,Is mutated in Nijmegen breakage syndrome (NBS). Patients with NBS exhibit chromosomal instability, resulting in hypersensitivity to irradiation and cancer predisposition. Nibrin forms a manganese-sensitive complex with hMre11 and hRAD50 that has single strand DNA endonuclease and exonuclease activities and is likely to be important for DNA excision, repair, and stability. This nibrin/Mre11/RAD50 complex is inhibited by BRCA1. The ATM (ataxia telangiectasia mutated) kinase has been shown to phosphorylate nibrin in an S-phase checkpoint pathway. Nibrin levels are elevated in testis tissue, suggesting a possible role in meiotic recombination. Nibrin may also be involved in telomere length maintenance.
  • Synonyms

    NBN; nibrin; NBS, NBS1, Nijmegen breakage syndrome 1 (nibrin); AT V1; AT V2; ATV; cell cycle regulatory protein p95; Nijmegen breakage syndrome 1 (nibrin); p95 protein of the MRE11/RAD50 complex; NBS; P95; NBS1; AT-V1; AT-V2; FLJ10155; MGC87362;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NBN-3957HCL Recombinant Human NBN 293 Cell Lysate HEK293 N/A
Human NBN-001H Recombinant Human NBN Protein, His-tagged E.coli His
Human NBN-01H Recombinant Human NBN Protein, His-tagged E.coli His 461-754
Human NBN-2479H Recombinant Human NBN Protein, His-tagged E.coli N-His Pro498-Arg754
Human NBN-2480H Recombinant Human NBN Protein, His-tagged E.coli N-His Met1-Arg218
Rat NBN-3912R Recombinant Rat NBN Protein Mammalian Cell His
Rat NBN-3571R-B Recombinant Rat NBN Protein Pre-coupled Magnetic Beads HEK293
Rat NBN-3571R Recombinant Rat NBN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque NBN-2951R Recombinant Rhesus monkey NBN Protein, His-tagged Mammalian Cell His
Rhesus Macaque NBN-2771R Recombinant Rhesus Macaque NBN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque NBN-2771R-B Recombinant Rhesus Macaque NBN Protein Pre-coupled Magnetic Beads HEK293
Zebrafish NBN-2289Z Recombinant Zebrafish NBN Mammalian Cell His
Chicken NBN-5909C Recombinant Chicken NBN Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • NBN Related Research Area

NBN involved in several pathways and played different roles in them. We selected most pathways NBN participated on our site, such as Homologous recombination, which may be useful for your reference. Also, other proteins which involved in the same pathway with NBN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Homologous recombinationRPA2;RPA4;FUZ;XRCC3;BRCA2;SHFM1;POLD2;RAD51D;MUS81

NBN has several biochemical functions, for example, contributes_to ATP-dependent DNA helicase activity, contributes_to damaged DNA binding, protein N-terminus binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NBN itself. We selected most functions NBN had, and list some proteins which have the same functions with NBN. You can find most of the proteins on our site.

Function Related Protein
contributes_to ATP-dependent DNA helicase activityMCM4;RAD50;MCM6;MRE11A;MCM7;NBN
contributes_to damaged DNA bindingDDB1;CUL4B;NBN;DDB2
protein N-terminus bindingNCOR2;FEZ1;TRP53;SERPINB1A;TBL1XR1;SYNGR3;PHB2;PARP1;RPS21
protein bindingMOBP;OAZ3;JMY;LGI4;FOXP3;DGKQ;ODC1;RAB33B;FAM161A
transcription factor bindingDIP2B;TAF7;PYDC3;FOS;CSNK2B;ATG7;PDCD11;TMEM173;CEBPA

NBN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NBN here. Most of them are supplied by our site. Hope this information will be useful for your research of NBN.

MDC1

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