Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953 Learn More

NCK2

Official Full Name

NCK adaptor protein 2
Overview

This gene encodes a member of the NCK family of adaptor proteins. The protein contains three SH3 domains and one SH2 domain. The protein has no known catalytic function but has been shown to bind and recruit various proteins involved in the regulation of receptor protein tyrosine kinases. It is through these regulatory activities that this protein is believed to be involved in cytoskeletal reorganization. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Synonyms

NCK2; NCK adaptor protein 2; cytoplasmic protein NCK2; NCKbeta; SH2/SH3 adaptor protein NCK-beta; growth factor receptor-bound protein 4; noncatalytic region of tyrosine kinase, beta; GRB4;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse

Source

E.coli
HEK293
HEK293T
Mammalian Cell

Tag

His
His (Fc)
Avi
SUMO
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	NCK2-29113TH	Recombinant Human NCK2, His-tagged	E.coli	His		Inquiry
Human	NCK2-49H	Recombinant Human NCK Adaptor Protein 2	E.coli	N/A		Inquiry
Human	NCK2-15879H	Recombinant Human NCK2, His-tagged	E.coli	His	1-380aa	Inquiry
Human	NCK2-3945HCL	Recombinant Human NCK2 293 Cell Lysate	HEK293	N/A		Inquiry
Human	NCK2-3946HCL	Recombinant Human NCK2 293 Cell Lysate	HEK293	N/A		Inquiry
Human	NCK2-3267H	Recombinant Human NCK2 protein, His-SUMO-tagged	E.coli	His-SUMO	1-380aa	Inquiry
Human	NCK2-5136H	Recombinant Human NCK2 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Mouse	NCK2-10471M	Recombinant Mouse NCK2 Protein	Mammalian Cell	His		Inquiry
Mouse	NCK2-5941M-B	Recombinant Mouse NCK2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	NCK2-5941M	Recombinant Mouse NCK2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	Nck2-4311M	Recombinant Mouse Nck2 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Chicken	NCK2-2511C	Recombinant Chicken NCK2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

NCK2 involved in several pathways and played different roles in them. We selected most pathways NCK2 participated on our site, such as ErbB signaling pathway, Axon guidance, T cell receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NCK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
ErbB signaling pathway	CBLB;GSK3AA;PIK3CG;AKT2;CDKN1BB;PIK3CA;PLCG2;MAPK3;TGFA
Axon guidance	NADL1.1;CSF2;EFNA2A;DUSP9;GPC1A;KRAS;PPP3CA;DUSP6;EFNB3
T cell receptor signaling pathway	OXSR1A;GRB2;VAV2;CD8B;GRAPA;PAK1;VAV1;SLA1;MAP3K14
Pathogenic Escherichia coli infection	KRT18;CTTN;HCLS1;ABL1;TUBA4A;ROCK2;EZR;NCK1;TUBB2B

NCK2 has several biochemical functions, for example, SH3/SH2 adaptor activity, cytoskeletal adaptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NCK2 itself. We selected most functions NCK2 had, and list some proteins which have the same functions with NCK2. You can find most of the proteins on our site.

Function	Related Protein
SH3/SH2 adaptor activity	SKAP1;PAG1;GRAP;NCK1;CNTNAP1;EPS8;SH2D2A;LAT;STAP1
cytoskeletal adaptor activity	COX4I2;GAS2L2;BIN3;NCK1;NCK2;BAIAP2L1;BAIAP2;GAS2L1;BAIAP2L2B
protein binding	S100A16;SNX15;RMI1;SMPDL3A;TMEM190;SPTSSB;PHF10;MAGEB4;HTR3E
protein complex binding	ABI1;VPS28;CPD;YWHAB;ULK1;RIPK1;SKAP1;RPTOR;Ctsl
receptor signaling complex scaffold activity	MAGI2;MAPK8IP3;LRRK2;ROPN1B;CARD10;MMS19;GRIP1;CD3E;LDLRAP1
scaffold protein binding	NOS1;SCN5A;MAPK3;CACNA1G;CHUK;PANX1;GRID2;NLRP1;CRIPT

NCK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NCK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NCK2.

RHOU; CHN1; PAK1; CBLB