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NCOA2

  • Official Full Name

    nuclear receptor coactivator 2

  • Overview

    The NCOA2 gene encodes nuclear receptor coactivator 2, which aids in the function of nuclear hormone receptors. Nuclear hormone receptors are conditional transcription factors that play important roles in various aspects of cell growth, development, and homeostasis by controlling expression of specific genes. Members of the nuclear hormone receptor superfamily, which includes the 5 steroid receptors and class II nuclear receptors (see below), are structurally characterized by 3 distinct domains: an N-terminal transcriptional activation domain, a central DNA-binding domain, and a C-terminal hormone-binding domain. Before the binding of hormone, steroid receptors, which are sometimes called class I of the nuclear hormone receptor family, remain inactive in a complex with heat-shock protein-90 (MIM 140571) and other stress family proteins. Binding of hormone induces critical conformational changes in steroid receptors that cause them to dissociate from the inhibitory complex, bind as homodimers to specific DNA enhancer elements associated with target genes, and modulate that genes transcription. After binding to enhancer elements, transcription factors require transcriptional coactivator proteins to mediate their stimulation of transcription initiation (Hong et al., 1997 [PubMed 9111344]).[supplied by OMIM, Nov 2010]
  • Synonyms

    NCOA2; nuclear receptor coactivator 2; SRC2; TIF2; GRIP1; KAT13C; NCoA-2; bHLHe75; hTIF2; transcriptional intermediary factor 2; class E basic helix-loop-helix protein 75; glucocorticoid receptor-interacting protein-1;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Rat
  • Zebrafish
  • E. coli
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NCOA2-3942HCL Recombinant Human NCOA2 293 Cell Lysate HEK293 N/A
Human NCOA2-23H Recombinant Human NCOA2 Protein, N-His-tagged E. coli N-His Met1-Ile280
Rat NCOA2-3923R Recombinant Rat NCOA2 Protein Mammalian Cell His
Rat NCOA2-3581R Recombinant Rat NCOA2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat NCOA2-3581R-B Recombinant Rat NCOA2 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish NCOA2-9291Z Recombinant Zebrafish NCOA2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • NCOA2 Related Articles
  • NCOA2 Related Research Area

NCOA2 involved in several pathways and played different roles in them. We selected most pathways NCOA2 participated on our site, such as Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3, Activation of gene expression by SREBF (SREBP), Adipogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with NCOA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3HIST3H2BB;KDM4C;HIST4H4;KDM1A;NCOA2;HIST2H3C
Activation of gene expression by SREBF (SREBP)PMVK;NFYBB;MTF1;CREBBP;NFYAL;NCOA2;HELZ2;CYP51A1;NFYBA
AdipogenesisCEBPB;MIXL1;HMGA1-RS1;BMP3;AHR;EGR2;FOXC2;CDKN1A;AGPAT2
Androgen receptor signaling pathwayPARK7;NCOA2;AES;POU2F1B;RAD54L2;HTATIP;RHOB;PIAS3;KAT5
BMAL1:CLOCK,NPAS2 activates circadian gene expressionCREBBP;CARM1;HELZ2;CRY2;NCOA2;DBP;NRIP1;CRY1;NAMPT
Bile acid and bile salt metabolismSLC27A2A;ACOT8;CYP27A1;BRSK2;AKR1C4;CYP46A1;AKR1C6;Alb;NCOA2
Biological oxidationsUGT1B2;DPEP2;CYP8B2;SLC35D1A;CYP3C4;PRKRA;AKR1A1;CYP4T8;SULT2ST2
Chromatin modifying enzymesKDM4C;KDM5BB;SUZ12A;COPRS;KANSL3;PAX3A;PRMT5;PHF21A;MSL1

NCOA2 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NCOA2 itself. We selected most functions NCOA2 had, and list some proteins which have the same functions with NCOA2. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II core promoter proximal region sequence-specific DNA bindingRBPJ;EHF;RBPJA;RFX1;MYC;PRDM1;NR4A3;ATF3;GCM1
RNA polymerase II intronic transcription regulatory region sequence-specific DNA bindingHSF1;SMYD3;NCOA2;ZNF350;VAX2;VAX1;HSF2;ZC3H8
chromatin bindingTP73;MPO;ZNF143;POU5F3;SKOR2;SOX14;PCGF2;ASH1L;EED
histone acetyltransferase activityKAT7A;NCOA2;KAT8;HTATIP;HAT1;EP300;CSRP2BP;TAF1;METTL8
ligand-dependent nuclear receptor bindingPROX1;NCOA1;SMARCD3;UBA3;PPARGC1A;NCOA3;NCOR2;TADA3;ISL1
ligand-dependent nuclear receptor transcription coactivator activityHELZ2;SMARCD3;ENY2;MED1;MED17;PRKCBB;AASS;CALCOCO1;PRKCB
nuclear hormone receptor bindingSIRT1;NCOA3;Ankar;BUD31;ACTN4;TCF7L2;MED1;EP300;NCOA1
protein bindingADAP2;ALKBH8;PRR3;C12orf49;GNA13;Ctsl;IL4;TRIM16;DNAJA1
protein dimerization activityNHLH2;LDB1A;PDCD6;POLR2J;HES2.2;AHRR;HER8A;CELSR1;GARS
thyroid hormone receptor coactivator activityMED1;NCOA2;MED16;ACTN2
transcription coactivator activityJUNB;NFKB2;KAT6A;CBFB;MED6;MAX;LPIN2;MED16;PDLIM1
transcription factor bindingEP300;SIRT1;PPP1R13BA;ARHGEF2;HEY1;PRKDC;RARA;TCF7L2;KAT2B

NCOA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NCOA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NCOA2.

ESR1; AR; DDX17; DDX5; 20-hydroxycholesterol; 25-hydroxycholestero; (22r)-22-hydroxycholesterol; TP53; CTNNB1; TAF9

Morzadec, C; Macoch, M; et al. Nrf2 expression and activity in human T lymphocytes: stimulation by T cell receptor activation and priming by inorganic arsenic and tert-butylhydroquinone. FREE RADICAL BIOLOGY AND MEDICINE 71:133-145(2014).
Dobroyolna, J; Chinenov, Y; et al. Glucocorticoid-Dependent Phosphorylation of the Transcriptional Coregulator GRIP1. MOLECULAR AND CELLULAR BIOLOGY 32:730-739(2012).
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