NDUFA13
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Official Full Name
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
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Overview
This gene encodes a subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain. The protein is required for complex I assembly and electron transfer activity. The protein binds the signal transducers and activators of transcription 3 (STAT3) transcription factor, and can function as a tumor suppressor. The human protein purified from mitochondria migrates at approximately 16 kDa. Transcripts originating from an upstream promoter and capable of expressing a protein with a longer N-terminus have been found, but their biological validity has not been determined. -
Synonyms
NDUFA13; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13; B16.6; CDA016; CGI 39; complex I B16.6 subunit; GRIM 19; GRIM19; CI-B16.6; complex I-B16.6; cell death-regulatory protein GRIM19; cell death regulatory protein GRIM-19; NADH-ubiquinone oxidoreductase B16.6 subunit; gene associated with retinoic and IFN-induced mortality 19 protein; gene associated with retinoic and interferon-induced mortality 19 protein; CGI-39; GRIM-19; FLJ58045; FLJ59191;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Bos taurus (Bovine)
- Cynomolgus Monkey
- Dictyostelium discoideum (Slime mold)
- Gorilla gorilla gorilla (Western lowland gorilla)
- Homo sapiens (Human)
- Human
- Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
- Mouse
- Mus musculus (Mouse)
- Pan troglodytes (Chimpanzee)
- Pongo pygmaeus (Bornean orangutan)
- Zebrafish
- E.coli
- E.coli expression system
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- HIS
- His (Fc)
- Avi
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
NDUFA13 involved in several pathways and played different roles in them. We selected most pathways NDUFA13 participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Non-alcoholic fatty liver disease (NAFLD), which may be useful for your reference. Also, other proteins which involved in the same pathway with NDUFA13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Oxidative phosphorylation | ATP5IB;ATP6V1D;PPA1B;COX11;COX4I2;UQCRC2A;ATP5IA;COX7B2;NDUFV1 |
| Metabolic pathways | MLYCD;B3GNT5A;CKB;GNPDA1;POLR3C;CERS2A;CHDH;CBR1L;POLR1E |
| Non-alcoholic fatty liver disease (NAFLD) | NDUFA2;COX7A1;CASP8;UQCRFS1;PIK3CB;PIK3R5;MAPK10;NDUFB6;NDUFC2-KCTD14 |
| Alzheimers disease | UQCR11;COX6A1;FAS;NDUFB1;NDUFS3;NDUFS4;SDHB;NDUFC2;CAPN1 |
| Parkinsons disease | Casp3;CYCS;GNAI3;COX7B;NDUFA6;UBA1;NDUFA10;ATP5A1;COX7A2L |
| Huntingtons disease | NDUFA6;POLR2J;NDUFS6;DNALI1;HAP1;POLR2K;TFAM;COX6B2;NDUFC2-KCTD14 |
NDUFA13 has several biochemical functions, for example, ATP binding, NADH dehydrogenase (ubiquinone) activity, NADH dehydrogenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NDUFA13 itself. We selected most functions NDUFA13 had, and list some proteins which have the same functions with NDUFA13. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | MOV10;RAF1A;MKKS;ATP8A1;SIK2A;PTK2BB;DDX17;PL10;DDX39B |
| NADH dehydrogenase (ubiquinone) activity | NDUFA10;NDUFB10;NDUFAF2;NDUFS1;NDUFS4;NDUFA13;NDUFB8;NDUFB3;NDUFS2 |
| NADH dehydrogenase activity | NDUFA9;NDUFA9A;NDUFS3;NDUFA13 |
| protein binding | IL15RA;TUFM;PDE4A;CLCF1;UBE2Q1;PLEKHF2;F2;HER11;MLC1 |
NDUFA13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NDUFA13 here. Most of them are supplied by our site. Hope this information will be useful for your research of NDUFA13.
HTRA2; NOD2; NDUFA2; XRN1; TSG101; SLC22A20; RTEL1-TNFRSF6B; TIMM23; NDUFS4
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