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NDUFAF2

Official Full Name

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 2
Overview

NADH:ubiquinone oxidoreductase (complex I) catalyzes the transfer of electrons from NADH to ubiquinone (coenzyme Q) in the first step of the mitochondrial respiratory chain, resulting in the translocation of protons across the inner mitochondrial membrane. This gene encodes a complex I assembly factor. Mutations in this gene cause progressive encephalopathy resulting from mitochondrial complex I deficiency.
Synonyms

NDUFAF2; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 2; NDUFA12 like , NDUFA12L; mimitin, mitochondrial; B17.2L; mimitin; MMTN; Myc induced mitochondrial protein; NDUFA12-like protein; Myc-induced mitochondrial protein; NDUFA12L; F;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rhesus Macaque
Zebrafish

Source

E.coli
HEK293
HEK293T
Mammalian Cell

Tag

His
His (Fc)
Avi
Myc
DDK
Myc|DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	NDUFAF2-946H	Recombinant Human NDUFAF2	Mammalian Cell	His		Inquiry
Human	NDUFAF2-30238TH	Recombinant Human NDUFAF2, His-tagged	E.coli	His	169 amino acids	Inquiry
Human	NDUFAF2-1008H	Recombinant Human NDUFAF2, His-tagged	E.coli	His		Inquiry
Human	NDUFAF2-1230H	Recombinant Human NDUFAF2, His-tagged	E.coli	His	1-169aa	$319 / 25ug
Human	NDUFAF2-436HCL	Recombinant Human NDUFAF2 lysate	HEK293	N/A		Inquiry
Human	NDUFAF2-3600H-B	Recombinant Human NDUFAF2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Human	NDUFAF2-3600H	Recombinant Human NDUFAF2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Human	NDUFAF2-517H	Recombinant Human NDUFAF2 Protein, MYC/DDK-tagged	HEK293	Myc/DDK		Inquiry
Mouse	Ndufaf2-4336M	Recombinant Mouse Ndufaf2 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Rhesus Macaque	NDUFAF2-2978R	Recombinant Rhesus monkey NDUFAF2 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	NDUFAF2-2797R-B	Recombinant Rhesus Macaque NDUFAF2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rhesus Macaque	NDUFAF2-2797R	Recombinant Rhesus Macaque NDUFAF2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Zebrafish	NDUFAF2-6361Z	Recombinant Zebrafish NDUFAF2	Mammalian Cell	His		Inquiry
Chicken	NDUFAF2-4251C	Recombinant Chicken NDUFAF2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
NDUFAF2 Related Articles

NDUFAF2 involved in several pathways and played different roles in them. We selected most pathways NDUFAF2 participated on our site, such as Metabolism, Respiratory electron transport, Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins., which may be useful for your reference. Also, other proteins which involved in the same pathway with NDUFAF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Metabolism	IVD;MED25;APOA4B.1;CYP2S1;BHMT2;CERS5;ABHD4;FAM213B;ACAD11
Respiratory electron transport	SCO1;C2orf56;C20orf7;COX11;COX16;NDUFA11;ETFDH;ETFA;NDUFAF4
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	NDUFAF2;ETFB;C2orf56;NDUFAF6;UCP2;SCO1;LRPPRC;COX14;NDUFAF5
The citric acid (TCA) cycle and respiratory electron transport	SCO1;ADHFE1;NDUFAF7;ETFA;SLC25A27;NDUFAF4;C20orf7;PDP2;NDUFAF3
Validated targets of C-MYC transcriptional activation	PEG10;NDUFAF2;SERPINI1;MINA;MTDH;PRDX3;IREB2;MYCT1;LIN28B

NDUFAF2 has several biochemical functions, for example, NADH dehydrogenase (ubiquinone) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NDUFAF2 itself. We selected most functions NDUFAF2 had, and list some proteins which have the same functions with NDUFAF2. You can find most of the proteins on our site.

Function	Related Protein
NADH dehydrogenase (ubiquinone) activity	NDUFB4;NDUFC2-KCTD14;NDUFS8;NDUFB2;NDUFS5;NDUFS2;NDUFV1;NDUFA5;NDUFA13

NDUFAF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NDUFAF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NDUFAF2.

OPTN; ATXN3; CHST15

Schlehe, JS; Journel, MSM; et al. The mitochondrial disease associated protein Ndufaf2 is dispensable for Complex-1 assembly but critical for the regulation of oxidative stress. NEUROBIOLOGY OF DISEASE 58:57-67(2013).

Pereira, B; Videira, A; et al. Novel Insights into the Role of Neurospora crassa NDUFAF2, an Evolutionarily Conserved Mitochondrial Complex I Assembly Factor. MOLECULAR AND CELLULAR BIOLOGY 33:2623-2634(2013).