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NDUFAF4

  • Official Full Name

    NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 4

  • Overview

    NADH:ubiquinone oxidoreductase (complex I) catalyzes the transfer of electrons from NADH to ubiquinone (coenzyme Q) in the first step of the mitochondrial respiratory chain, resulting in the translocation of protons across the inner mitochondrial membrane. This gene encodes a complex I assembly factor. Mutations in this gene are a cause of mitochondrial complex I deficiency.
  • Synonyms

    NDUFAF4; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 4; C6orf66, chromosome 6 open reading frame 66; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4; bA22L21.1; HRPAP20; HSPC125; My013; C6orf66; Hormone-regulated proliferation-associated protein of 20 kDa; NDUF4_HUMAN; hormone-regulated proliferation-associated protein, 20 kDa;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NDUFAF4-7199H Recombinant Human NADH Dehydrogenase (Ubiquinone) Complex I, Assembly Factor 4, His-tagged E.coli His 1-175aa
Human NDUFAF4-3910HCL Recombinant Human NDUFAF4 293 Cell Lysate HEK293 N/A
Human NDUFAF4-5461H Recombinant Human NDUFAF4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse Ndufaf4-4338M Recombinant Mouse Ndufaf4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat NDUFAF4-3939R Recombinant Rat NDUFAF4 Protein Mammalian Cell His
Rat NDUFAF4-3597R Recombinant Rat NDUFAF4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat NDUFAF4-3597R-B Recombinant Rat NDUFAF4 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque NDUFAF4-2980R Recombinant Rhesus monkey NDUFAF4 Protein, His-tagged Mammalian Cell His
Rhesus Macaque NDUFAF4-2799R-B Recombinant Rhesus Macaque NDUFAF4 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque NDUFAF4-2799R Recombinant Rhesus Macaque NDUFAF4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • NDUFAF4 Related Articles

NDUFAF4 involved in several pathways and played different roles in them. We selected most pathways NDUFAF4 participated on our site, such as Metabolism, Respiratory electron transport, Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins., which may be useful for your reference. Also, other proteins which involved in the same pathway with NDUFAF4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MetabolismACY3;UST;CBLC-1;AKAP5;GLIPR1;YY2;SULT2ST1;CKM;IVD
Respiratory electron transportNDUFAF2;NDUFAF4;TIMMDC1;ETFDH;ETFA;NDUFAF7;SCO1;SURF1;C2orf56
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.ETFB;SURF1;NDUFAF2;ATP5L;NDUFAF3;UCP2;UCP3;COX16;SCO1
The citric acid (TCA) cycle and respiratory electron transportNDUFAF3;NDUFAF4;ADHFE1;ATP5S;COX16;TACO1;MPC1;NDUFAF2;SLC25A27

NDUFAF4 has several biochemical functions, for example, calmodulin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NDUFAF4 itself. We selected most functions NDUFAF4 had, and list some proteins which have the same functions with NDUFAF4. You can find most of the proteins on our site.

Function Related Protein
calmodulin bindingCALD1B;DCX;ADD2;UPF3B;CAMK1GB;TRPV5;ORAI1;ADCY1;CAMK1G
protein bindingSPN;OLIG1;ACLY;ASB3;ALS2;STX4;GRN;Tnfrsf23;UBLCP1

NDUFAF4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NDUFAF4 here. Most of them are supplied by our site. Hope this information will be useful for your research of NDUFAF4.

NDUFAF3; NDUFAF3; NDUFS5; NDUFS7; P; TIMMDC1; NDUFA13

Marcus, D; Lichtenstein, M; et al. Replacement of the C6ORF66 Assembly Factor (NDUFAF4) Restores Complex I Activity in Patient Cells. MOLECULAR MEDICINE 19:124-134(2013).
Rendon, OZ; Shoubridge, EA; et al. Early complex I assembly defects result in rapid turnover of the ND1 subunit. HUMAN MOLECULAR GENETICS 21:3815-3824(2012).
Dieteren, CEJ; Willems, PHGM; et al. Defective mitochondrial translation differently affects the live cell dynamics of complex I subunits. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS 1807:1624-1633(2011).
Saada, A; Vogel, RO; et al. Mutations in NDUFAF3 (C3ORF60), Encoding an NDUFAF4 (C6ORF66)-interacting Complex I Assembly Protein, Cause Fatal Neonatal Mitochondrial Disease. AMERICAN JOURNAL OF HUMAN GENETICS 84:718-727(2009).
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