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NDUFS1

  • Official Full Name

    NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)

  • Overview

    The protein encoded by this gene belongs to the complex I 75 kDa subunit family. Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. This protein is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized. Mutations in this gene are associated with complex I deficiency. Several transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    NDUFS1; NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase); NADH dehydrogenase (ubiquinone) Fe S protein 1 (75kD) (NADH coenzyme Q reductase); NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial; CI 75k; complex I 75kDa subunit; NADH ubiquinone oxidoreductase 75 kDa subunit; mitochondrial; Complex I 75Kd; Complex I, mitochondrial respiratory chain, 75 kD subunit; NADH coenzyme Q reductase; NADH dehydrogenase (ubiquinone) FeS protein 1 (75kD) (NADH coenzyme Q reductase); NADH ubiquinone oxidoreductase 75 kDa subunit mitochondrial; PRO1304; complex I, mitochondrial respiratory chain, 75-kD subunit; mitochondrial NADH-ubiquinone oxidoreductase 75 kDa subunit; CI-75k; CI-75Kd;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NDUFS1-272H Recombinant Human NDUFS1 Mammalian Cell His
Human NDUFS1-3898HCL Recombinant Human NDUFS1 293 Cell Lysate HEK293 N/A
Human NDUFS1-1716H Recombinant Human NDUFS1 protein, His & T7-tagged E.coli His/T7 Ala524~Cys727 (Accession # P28331)
Human NDUFS1-3606H Recombinant Human NDUFS1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human NDUFS1-4064H Recombinant Human NDUFS1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human NDUFS1-3606H-B Recombinant Human NDUFS1 Protein Pre-coupled Magnetic Beads HEK293
Human NDUFS1-4675H Recombinant Human NDUFS1 Protein (Ala524-Cys727), N-His tagged E.coli N-His Ala524-Cys727
Mouse NDUFS1-10541M Recombinant Mouse NDUFS1 Protein Mammalian Cell His
Mouse NDUFS1-5988M Recombinant Mouse NDUFS1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Ndufs1-4344M Recombinant Mouse Ndufs1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse NDUFS1-5988M-B Recombinant Mouse NDUFS1 Protein Pre-coupled Magnetic Beads HEK293
Rat NDUFS1-3942R Recombinant Rat NDUFS1 Protein Mammalian Cell His
Rat NDUFS1-3600R Recombinant Rat NDUFS1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat NDUFS1-3600R-B Recombinant Rat NDUFS1 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey NDUFS1-738C Recombinant Cynomolgus NDUFS1 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey NDUFS1-482C-B Recombinant Cynomolgus Monkey NDUFS1 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey NDUFS1-482C Recombinant Cynomolgus Monkey NDUFS1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish NDUFS1-1841Z Recombinant Zebrafish NDUFS1 Mammalian Cell His
Chicken NDUFS1-1656C Recombinant Chicken NDUFS1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

NDUFS1 involved in several pathways and played different roles in them. We selected most pathways NDUFS1 participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Non-alcoholic fatty liver disease (NAFLD), which may be useful for your reference. Also, other proteins which involved in the same pathway with NDUFS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Oxidative phosphorylationUQCRH;NDUFB2;COX7A3;SDHD;UQCR10;NDUFA3;NDUFC2-KCTD14;ATP6V1BA;ATP6V0A2B
Metabolic pathwaysST8SIA1;B3GNT4;PKM2;PIGO;PRODH;ATP6V1C1B;ALOX15;PYGMA;NME2
Non-alcoholic fatty liver disease (NAFLD)IL1A;COX7A2;NDUFA2;AKT1;MLXIPL;TRAF2;PRKAB1;NDUFA4L2;RXRA
Alzheimers diseaseSNCA;CALM3;CALM4;ATP5G1;PLCB3;COX6B2;NOS1;mt-Atp8;COX6B1
Parkinsons diseaseSDHA;NDUFV3;ATP5D;NDUFB10;ATP5O;SLC25A6;DRD1A;COX6A2;UBE2J1
Huntingtons diseasePOLR2F;NDUFA2;COX6B2;NDUFS5;NDUFC2-KCTD14;NDUFA4L2;COX6A2;ATP5G1;NDUFAB1

NDUFS1 has several biochemical functions, for example, 2 iron, 2 sulfur cluster binding, 4 iron, 4 sulfur cluster binding, contributes_to NADH dehydrogenase (ubiquinone) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NDUFS1 itself. We selected most functions NDUFS1 had, and list some proteins which have the same functions with NDUFS1. You can find most of the proteins on our site.

Function Related Protein
2 iron, 2 sulfur cluster bindingAOX3;FDX1L;AOX4;XDH;FDX1B;GLRX2;CISD3;SDHB;NDUFS1
4 iron, 4 sulfur cluster bindingRTEL1;DDX11;POLD1;PRIM2;IREB2;NDUFS8A;ETFDH;NUBP1;ISCUB
contributes_to NADH dehydrogenase (ubiquinone) activityNDUFS1;NDUFS8;NDUFS4
NADH dehydrogenase (ubiquinone) activityNDUFB10;NDUFA5;NDUFV2;NDUFB7;NDUFV3;NDUFA10;NDUFB3;NDUFS3;NDUFA1
electron carrier activityGLDC;ACADVL;NDUFS6;NDUFS3;COX7A3;AOX3L1;TXNRD1;COX7A1;AKR7A2
iron-sulfur cluster bindingDPYDB;NDUFS1;PROZA;RPS3;AOX3L1;AIFM4;FDX1B;ELP3;ABAT
metal ion bindingZNF583;AGFG1B;COL3A1;ZNF529;NRXN1B;ACSM2;GALNTL2;ZNF823;CSH2
protein bindingTIPIN;NR1H2;IL18;DPYSL4;VTN;SULT2A1;APLF;HHIPL2;DNAJC5B

NDUFS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NDUFS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NDUFS1.

NDUFA2; HLA-B; NOA1; TNIP3; ECE2; C1QTNF9; 15-deoxy-delta(12,14; E2F3; NDUFS4; NDUFS5; NDUFS7; NDUFS6; NDUFS3; MYC; VCAM1; NDUFV2; Rab5c; Bmpr1a; HTT

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