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NDUFS4

Official Full Name

NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)
Overview

This gene encodes an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), or NADH:ubiquinone oxidoreductase, the first multi-subunit enzyme complex of the mitochondrial respiratory chain. Complex I plays a vital role in cellular ATP production, the primary source of energy for many crucial processes in living cells. It removes electrons from NADH and passes them by a series of different protein-coupled redox centers to the electron acceptor ubiquinone. In well-coupled mitochondria, the electron flux leads to ATP generation via the building of a proton gradient across the inner membrane. Complex I is composed of at least 41 subunits, of which 7 are encoded by the mitochondrial genome and the remainder by nuclear genes.
Synonyms

NDUFS4; NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase); NADH dehydrogenase (ubiquinone) Fe S protein 4 (18kD) (NADH coenzyme Q reductase); NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial; AQDQ; CI 18;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat
Zebrafish

Source

E.coli
HEK293
HEK293T
Mammalian Cell

Tag

GST
His
His (Fc)
Avi
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	NDUFS4-29482TH	Recombinant Human NDUFS4	E.coli	N/A		Inquiry
Human	NDUFS4-2509H	Recombinant Human NADH Dehydrogenase (ubiquinone) Fe-S Protein 4, 18kDa (NADH-coenzyme Q reductase)	E.coli	N/A	43-175aa	Inquiry
Human	NDUFS4-367H	Recombinant Human NDUFS4	E.coli	N/A		Inquiry
Human	NDUFS4-28208TH	Recombinant Human NDUFS4	E.coli	N/A	133 amino acids	Inquiry
Human	NDUFS4-1240H	Recombinant Human NDUFS4, His-tagged	E.coli	His	1-175aa	$319 / 25ug
Human	NDUFS4-3895HCL	Recombinant Human NDUFS4 293 Cell Lysate	HEK293	N/A		Inquiry
Human	NDUFS4-301403H	Recombinant Human NDUFS4 protein, GST-tagged	E.coli	GST	Ala115-Lys175	Inquiry
Mouse	Ndufs4-4346M	Recombinant Mouse Ndufs4 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Rat	NDUFS4-3944R	Recombinant Rat NDUFS4 Protein	Mammalian Cell	His		Inquiry
Rat	NDUFS4-3602R-B	Recombinant Rat NDUFS4 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	NDUFS4-3602R	Recombinant Rat NDUFS4 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Zebrafish	NDUFS4-2842Z	Recombinant Zebrafish NDUFS4	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

NDUFS4 involved in several pathways and played different roles in them. We selected most pathways NDUFS4 participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Non-alcoholic fatty liver disease (NAFLD), which may be useful for your reference. Also, other proteins which involved in the same pathway with NDUFS4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Oxidative phosphorylation	NDUFB8;COX5A;ATP6V1A;ATP5IB;UQCRC2A;NDUFA4L;MT-ATP6;ATP6V1C1B;ATP5J
Metabolic pathways	GAD2;TREH;GBA3;ATP5G3A;MAT2B;ALDOA;B3GALT4;ITPK1;PAFAH1B2
Non-alcoholic fatty liver disease (NAFLD)	COX7B2;COX4I2;UQCRH;BAX;NDUFV2;PIK3R2;UQCR11;MAPK8;NDUFAB1
Alzheimers disease	NDUFB8;MAPK3;SDHD;COX4I1;GRIN2D;NDUFB2;CASP12;NDUFV3;NDUFS6
Parkinsons disease	SLC25A5;SLC18A2;NDUFS3;SNCA;NDUFV2;SDHB;DRD1A;TH;GNAL
Huntingtons disease	GRIN1;NDUFB5;SP1;COX7A1;HDAC2;NDUFA9;NDUFB7;SLC25A5;CREB3L3

NDUFS4 has several biochemical functions, for example, NADH dehydrogenase (ubiquinone) activity, contributes_to NADH dehydrogenase (ubiquinone) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NDUFS4 itself. We selected most functions NDUFS4 had, and list some proteins which have the same functions with NDUFS4. You can find most of the proteins on our site.

Function	Related Protein
NADH dehydrogenase (ubiquinone) activity	NDUFA2;NDUFS7;NDUFC2;NDUFA13;NDUFB10;NDUFB6;NDUFB3;NDUFB4;NDUFA4
contributes_to NADH dehydrogenase (ubiquinone) activity	NDUFS4;NDUFS1;NDUFS8

NDUFS4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NDUFS4 here. Most of them are supplied by our site. Hope this information will be useful for your research of NDUFS4.

NDUFA2; UBE2G2; NDUFS8; COX7A2L; NDUFS5; NDUFS2; NDUFS3; NDUFB4; NDUFB8; NDUFA7; NDUFB10; MT-ND1; MT-ND4; MT-ND5; NDUFV2; NDUFS1; NDUFV1; NDUFV3