NDUFS6
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Official Full Name
NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase)
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Overview
This gene encodes a subunit of the NADH:ubiquinone oxidoreductase (complex I), which is the first enzyme complex in the electron transport chain of mitochondria. This complex functions in the transfer of electrons from NADH to the respiratory chain. The subunit encoded by this gene is one of seven subunits in the iron-sulfur protein fraction. Mutations in this gene cause mitochondrial complex I deficiency, a disease that causes a wide variety of clinical disorders, including neonatal disease and adult-onset neurodegenerative disorders. -
Synonyms
NDUFS6; NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase); NADH dehydrogenase (ubiquinone) Fe S protein 6 (13kD) (NADH coenzyme Q reductase); NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial; CI 13kA; complex I 13kDa subunit A; NADH dehydrogenase [ubiquinone] iron sulfur protein 6; mitochondrial; CI 13kD A; CI-13kD-A; Complex I 13kD A; Complex I-13kD-A; NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH coenzyme Q reductase); NADH dehydrogenase [ubiquinone] iron sulfur protein 6, mitochondrial; NADH ubiquinone oxidoreductase 13 kDa A subunit; NADH-ubiquinone oxidoreductase 13 kDa-A subunit; NDUS6_HUMAN; NADH:ubiquinone oxidoreductase NDUFS6 subunit; complex I, mitochondrial respiratory chain, 13-kD subunit; CI-13kA; CI13KDA;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Cynomolgus Monkey
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- NDUFS6 Related Articles
NDUFS6 involved in several pathways and played different roles in them. We selected most pathways NDUFS6 participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Non-alcoholic fatty liver disease (NAFLD), which may be useful for your reference. Also, other proteins which involved in the same pathway with NDUFS6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Oxidative phosphorylation | PPA1B;NDUFB11;ATP6V0E1;NDUFA3;NDUFB2;COX17;COX6B2;ATP5G1;SDHDB |
| Metabolic pathways | DCT;ALDH1A1;XYLT1;GBE1;DNMT3AA;NT5C3L;UMPS;GAL3ST1A;CKMT1B |
| Non-alcoholic fatty liver disease (NAFLD) | NDUFC1;NDUFB5;NDUFA4;RXRA;SDHB;NDUFS8;PRKAA1;COX4I2;NDUFC2 |
| Alzheimers disease | IDE;NDUFA10;COX6A2;TNFRSF1A;IL1B2;ATP5G3;MAPT;COX8A;ITPR2 |
| Parkinsons disease | SDHD;NDUFC2-KCTD14;NDUFA1;NDUFS4;UBE2G1;ATP5D;UQCR11;GPR37;NDUFB10 |
| Huntingtons disease | CYCS;COX7A1;HIP1;POLR2C;CASP8;mt-Atp8;Casp3;BAX;ATP5O |
NDUFS6 has several biochemical functions, for example, NADH dehydrogenase (ubiquinone) activity, electron carrier activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NDUFS6 itself. We selected most functions NDUFS6 had, and list some proteins which have the same functions with NDUFS6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NADH dehydrogenase (ubiquinone) activity | NDUFA9;NDUFC1;NDUFS8;NDUFA12;NDUFV3;NDUFA1;NDUFA5;NDUFA10;NDUFB6 |
| electron carrier activity | CYCSB;ACADL;HAAO;AOX3L1;AKR1B1;IDH3B;NDUFA12;DHDH;GLDC |
NDUFS6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NDUFS6 here. Most of them are supplied by our site. Hope this information will be useful for your research of NDUFS6.
NDUFA2; GDNF; MAP3K7; FGFR3; KCNH2; MAPK8IP2; MAPK6; NDUFS8; NDUFS5; NDUFS2; NDUFS3; NDUFA7; MT-ND4; NDUFV2; NDUFS1; Rab5c; NDUFV1; RAB7A; NDUFV3
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