Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains.;Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in;intracellular transport to axons and dendrites. This gene encodes the medium neurofilament protein. This protein is;commonly used as a biomarker of neuronal damage. Alternative splicing results in multiple transcript variants encoding;distinct isoforms.