NEU4
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Official Full Name
sialidase 4
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Overview
The protein encoded by this gene belongs to a family of glycohydrolytic enzymes, which remove terminal sialic acid residues from various sialo derivatives, such as glycoproteins, glycolipids, oligosaccharides, and gangliosides. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. -
Synonyms
NEU4; sialidase 4; sialidase-4; neuraminidase 4; N-acetyl-alpha-neuraminidase 4; FLJ35928; MGC18222; MGC102757;
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Recombinant Proteins
- Human
- Mouse
- Mus musculus (Mouse)
- Zebrafish
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- NEU4 Related Articles
NEU4 involved in several pathways and played different roles in them. We selected most pathways NEU4 participated on our site, such as Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Glycosphingolipid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with NEU4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Asparagine N-linked glycosylation | SERPINA1L;ST8SIA2;CTAGE5;STT3A;DAD1;TRAPPC2;SEC23IP;MPDU1B;ALG14 |
| Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | ST8SIA3;MPDU1B;ST3GAL3A;NEU4;GNE;NANP;ALG2;ST6GAL2B;ZNF408 |
| Glycosphingolipid metabolism | GLB1L;ARSD;SUMF2;ARSI;ARSF;ARSH;ARSE;CPTP;ARSJ |
| Metabolism | PDP2;AZIN2;MPC1;ACOT11B;APOBB.1;CDS1;SREBF2;TREH;CPNE3 |
| Metabolism of lipids and lipoproteins | EBP;PPP1R2;CHKA;SLC25A20;CYP4F22;FAAH2;GRHL1;PHOSPHO1;CYP2U1 |
| Metabolism of proteins | HYOU1;EXOC5;APEH;LMAN2;DPP4;GFER;KDELR3;SEC23IP;SCMH1 |
| Other glycan degradation | NEU3;MAN2B1;NEU4;AGA;GBA;NEU3.3;MAN2B2;FUCA2;NEU3.5 |
| Post-translational protein modification | PHC3;PREB;ST8SIA3;DOHH;NSMCE2;WDR85;GCNT3;DPAGT1;B3GNT8 |
NEU4 has several biochemical functions, for example, exo-alpha-(2->3)-sialidase activity, exo-alpha-(2->6)-sialidase activity, exo-alpha-(2->8)-sialidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NEU4 itself. We selected most functions NEU4 had, and list some proteins which have the same functions with NEU4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| exo-alpha-(2->3)-sialidase activity | NEU1;NEU2;NEU4;NEU3 |
| exo-alpha-(2->6)-sialidase activity | NEU4;NEU1;NEU2;NEU3 |
| exo-alpha-(2->8)-sialidase activity | NEU4;NEU3;NEU2;NEU1 |
| exo-alpha-sialidase activity | NEU3.3;NEU3;NEU3.5;NEU3.2;NEU3.1;ST3GAL5L;NEU4;NEU1;NEU3.4 |
| protein binding | AMOTL2;C3;RRM2B;HDHD3;CCER1;MYRIP;DNAJC7;EML1;CITED2 |
NEU4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NEU4 here. Most of them are supplied by our site. Hope this information will be useful for your research of NEU4.
MDFI; RHOXF2; PLSCR1; Dlg4; RBPMS
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