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NFAT5

Official Full Name

nuclear factor of activated T-cells 5, tonicity-responsive
Overview

The product of this gene is a member of the nuclear factors of activated T cells family of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. This protein regulates gene expression induced by osmotic stress in mammalian cells. Unlike monomeric members of this protein family, this protein exists as a homodimer and forms stable dimers with DNA elements. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms

NFAT5; nuclear factor of activated T-cells 5, tonicity-responsive; nuclear factor of activated T-cells 5; KIAA0827; NF AT5; NFATL1; NFATZ; OREBP; TONEBP; NFAT-like protein 1; TonE-binding protein; glutamine rich protein H65; T-cell transcription factor NF;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Rat

Source

HEK293
HEK293T
Mammalian Cell
Wheat Germ

Tag

His
His (Fc)
Avi
Myc|DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	NFAT5-1187HCL	Recombinant Human NFAT5 cell lysate	HEK293T	Myc/DDK		Inquiry
Human	NFAT5-30376TH	Recombinant Human NFAT5	Wheat Germ	N/A	110 amino acids	Inquiry
Rat	NFAT5-3969R	Recombinant Rat NFAT5 Protein	Mammalian Cell	His		Inquiry
Rat	NFAT5-3628R	Recombinant Rat NFAT5 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	NFAT5-3628R-B	Recombinant Rat NFAT5 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Chicken	NFAT5-4235C	Recombinant Chicken NFAT5	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
NFAT5 Related Articles

NFAT5 involved in several pathways and played different roles in them. We selected most pathways NFAT5 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with NFAT5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

NFAT5 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, protein binding, transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NFAT5 itself. We selected most functions NFAT5 had, and list some proteins which have the same functions with NFAT5. You can find most of the proteins on our site.

Function	Related Protein
RNA polymerase II core promoter proximal region sequence-specific DNA binding	NFIB;TCF3A;RBPJA;CC2D1A;MYF6;NFIC;GZF1;TTC6;PPARA
protein binding	NR2C1;NR5A2;UNG;ZFP143;TBX1;TAF10;PTH1R;MAGEA1;SCRN1
transcription factor activity, sequence-specific DNA binding	RFX1A;GATAD2A;EFCAB11;IRF1A;NFE2L2;ZNF567;E4F1;ZNF792;IRF1B
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	TFAP2E;DLX5;FOXD1;EGR2;CREB3;TCF12;NR4A2;HNF4A;EBF2

NFAT5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NFAT5 here. Most of them are supplied by our site. Hope this information will be useful for your research of NFAT5.

DDX5; DDX17; TBC1D4; mtfA; dsdna_dadt:dadt; lcn2_human_gene; s100a4_human_gene; ORF

Wiig, H; Schroder, A; et al. Immune cells control skin lymphatic electrolyte homeostasis and blood pressure. JOURNAL OF CLINICAL INVESTIGATION 123:2803-2815(2013).

Shaterian, A; Borboa, A; et al. Non-invasive detection of spatio-temporal activation of SBE and NFAT5 promoters in transgenic reporter mice following stroke. NEUROPATHOLOGY 32:118-123(2012).