NFRSF1B
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Overview
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. -
Synonyms
TNFRSF1B;tumor necrosis factor receptor superfamily, member 1B;p75;TBPII;TNFBR;TNFR2;CD120b;TNFR1B;TNFR80;TNF-R75;p75TNFR;TNF-R-II;p75 TNF receptor;tumor necrosis factor beta receptor;tumor necrosis factor binding protein 2;
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | NFRSF1B-590H | Recombinant Human TNFRSF1B | Insect Cell | N/A |
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- NFRSF1B Related Gene Family
NFRSF1B involved in several pathways and played different roles in them. We selected most pathways NFRSF1B participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with NFRSF1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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NFRSF1B has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by NFRSF1B itself. We selected most functions NFRSF1B had, and list some proteins which have the same functions with NFRSF1B. You can find most of the proteins on our site.
| Function | Related Protein |
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NFRSF1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NFRSF1B here. Most of them are supplied by our site. Hope this information will be useful for your research of NFRSF1B.
- Q&As
- Reviews
Q&As (5)
Ask a questionTNFRSF1B is a type I transmembrane protein with an extracellular domain containing cysteine-rich repeats. This domain is crucial for ligand binding, receptor trimerization, and subsequent signaling.
TNFRSF1B regulates inflammation by influencing the expression of inflammatory mediators. Dysregulation is associated with inflammatory diseases, highlighting its role in immune system homeostasis.
TNFRSF1B plays a role in apoptosis by influencing extrinsic apoptotic pathways. Its signaling can intersect with intrinsic pathways through crosstalk with mitochondria and pro-apoptotic proteins.
Post-translational modifications, including phosphorylation, modulate TNFRSF1B signaling. Phosphorylation events influence downstream signaling cascades and cellular responses to ligand binding.
TNFRSF1B binds specifically to TNF-β. Ligand binding induces conformational changes in the receptor, leading to the recruitment of signaling molecules and the initiation of downstream pathways.
Customer Reviews (3)
Write a reviewFast shipping and excellent service. This product is a lab essential.
Quality meets expectations. The consistency is perfect for our experiments.
Customer-centric service and high-quality products. Our experiments have benefited tremendously.
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