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NFS1

Official Full Name

NFS1 nitrogen fixation 1 homolog (S. cerevisiae)
Overview

Iron-sulfur clusters are required for the function of many cellular enzymes. The proteins encoded by this gene supply inorganic sulfur to these clusters by removing the sulfur from cysteine, creating alanine in the process. This gene uses alternate in-frame translation initiation sites to generate mitochondrial forms and cytoplasmic/nuclear forms. Selection of the alternative initiation sites is determined by the cytosolic pH. The encoded proteins belong to the class-V family of pyridoxal phosphate-dependent aminotransferases. Alternatively spliced transcript variants have been described.
Synonyms

NFS1; NFS1 nitrogen fixation 1 homolog (S. cerevisiae); nitrogen fixation 1 (S. cerevisiae, homolog); cysteine desulfurase, mitochondrial; IscS; NifS; HUSSY 08; nitrogen fixation gene 1; OTTHUMP00000030799; OTTHUMP00000030800; OTTHUMP00000179026; nitrogen-fixing bacteria S-like protein; HUSSY-08;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	NFS1-3844HCL	Recombinant Human NFS1 293 Cell Lysate	HEK293	N/A		Inquiry
Human	NFS1-01H	Recombinant Human NFS1 protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	NFS1-02H	Recombinant Human NFS1 protein, GST-tagged	Wheat Germ	GST	1-457aa	Inquiry
Zebrafish	NFS1-4074Z	Recombinant Zebrafish NFS1	Mammalian Cell	His		Inquiry
Chicken	NFS1-2543C	Recombinant Chicken NFS1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

NFS1 involved in several pathways and played different roles in them. We selected most pathways NFS1 participated on our site, such as Thiamine metabolism, Metabolic pathways, Sulfur relay system, which may be useful for your reference. Also, other proteins which involved in the same pathway with NFS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Thiamine metabolism	THTPA;TPK1;NTPCR;NFS1
Metabolic pathways	LPCAT2;CHIA;ACAA2;AGL;PCCA;RPIA;GAD1;TYR;NME2
Sulfur relay system	MOCS2;CTU1;URM1;MPST;TST;TRMU;LBH;NFS1;CTU2

NFS1 has several biochemical functions, for example, cysteine desulfurase activity, iron-sulfur cluster binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NFS1 itself. We selected most functions NFS1 had, and list some proteins which have the same functions with NFS1. You can find most of the proteins on our site.

Function	Related Protein
cysteine desulfurase activity
iron-sulfur cluster binding	RSAD1;PRIM2;CISD3;CMAH;RPS3;FDX1B;PROZA;AOX3;AOX4
metal ion binding	ZNFX1;SEMG2;ATP2C2;GRIN2A;ESRRGA;VAV1;ZFP574;ACY3.1;ZNF740B
protein binding	COL4A3;PRPF3;SIPA1L2;GOSR2;BTG3;CD5;INTS7;GBAS;HMGB3
protein homodimerization activity	STK25;PON3;BMP2B;PDXK;BOK;MYH7;TP53I3;ASMT;GRHPR
pyridoxal phosphate binding	SPTLC2B;CTHL;HINT2;CSAD;NFS1;GAD2;HDC;THNSL2;AGXT2

NFS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NFS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NFS1.

ABL1; FYN; GRB2; CLPP; RB1CC1