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NFYC

Official Full Name

nuclear transcription factor Y, gamma
Overview

This gene encodes one subunit of a trimeric complex forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoters of a variety of genes. The encoded protein, subunit C, forms a tight dimer with the B subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms

NFYC; nuclear transcription factor Y, gamma; nuclear transcription factor Y subunit gamma; CBF C; NF YC; transactivator HSM-1; transactivator HSM-1/2; CCAAT binding factor subunit C; transcription factor NF-Y, C subunit; CAAT box DNA-binding protein subun;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat
Zebrafish

Source

E.coli
HEK293
HEK293T
Mammalian Cell
Wheat Germ

Tag

His
His (Fc)
Avi
His|GST
Myc
DDK
N/A
N
GST

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	NFYC-29920TH	Recombinant Human NFYC	Wheat Germ	N/A	100 amino acids	Inquiry
Human	NFYC-3838HCL	Recombinant Human NFYC 293 Cell Lysate	HEK293	N/A		Inquiry
Human	NFYC-308H	Recombinant Human NFYC Protein, His/GST-tagged	E.coli	His/GST	Met1~Val263	$298 / 10ug
Human	NFYC-4700H	Recombinant Human NFYC Protein (Met1-Val263), N-GST tagged	E.coli	N-GST	Met1-Val263	Inquiry
Human	NFYC-2446H	Recombinant Human NFYC Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Mouse	Nfyc-4403M	Recombinant Mouse Nfyc Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Rat	NFYC-3979R	Recombinant Rat NFYC Protein	Mammalian Cell	His		Inquiry
Rat	NFYC-3638R	Recombinant Rat NFYC Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	NFYC-3638R-B	Recombinant Rat NFYC Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	NFYC-10040Z	Recombinant Zebrafish NFYC	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
NFYC Related Articles

NFYC involved in several pathways and played different roles in them. We selected most pathways NFYC participated on our site, such as Antigen processing and presentation, Tuberculosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with NFYC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Antigen processing and presentation	NFYA;HSP90AA1;CD4;HLA-DMA;IFI30;HLA-DRB4;TNF;RFXAP;HLA-B
Tuberculosis	TNF;IFNA4;CAMK2D;STAT1;IFNA16;IFNA6;CD74;LSP1;PMAP-36

NFYC has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NFYC itself. We selected most functions NFYC had, and list some proteins which have the same functions with NFYC. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	TOX4;GTF2F2A;DOT1L;CHD2;CENPC1;POLR2J3;HER8A;NKX2.4A;HER5
RNA polymerase II core promoter proximal region sequence-specific DNA binding	NR5A2;SIX1;MITFA;NPAS4;JUND;ETV4;CRX;MESP1;FUBP3
protein binding	GAPDHS;HSP90AB1;MPLKIP;PPID;PIBF1;SKAP1;INPPL1;FOXO1;FRMD7
protein heterodimerization activity	HOMER2;HIST3H2BB;NPM1;HIST1H2BP;TAP1;Fzd4;DDIT3;HIST1H2BO;HAND1
transcription coactivator activity	YY1;GATA4;POU2AF1;ACTL6B;KAT2B;ABT1;NEUROG3;BRCA1;JUNBB
transcription factor activity, sequence-specific DNA binding	IRF4A;TGIF2;TFAP2B;SMAD5;GABPB1;ATF3;TBX21;NR4A2A;ALX3
transcription factor binding	PBX1;PIM1;NCOR2;STAT3;POU5F1;TFDP1;TFAP2A;HTT;IRF4
contributes_to transcription regulatory region DNA binding	HDAC5;ATF4;HDAC4;TCF3;NR1H3;HAND1;NFYB;RXRA;TCF12
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	NR4A2;HOXC13;TCF21;NRL;TFAP2A;PITX1;NPAS4;NR1H2;GATA3

NFYC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NFYC here. Most of them are supplied by our site. Hope this information will be useful for your research of NFYC.

NFYB; NFYA; SNX2; GAPDH; CSN2; SP1; ATF6; LMO4; DR1; DST; SREBF2; bipA; ARID2; KIAA2018

Tremblay, AM; Wilson, BJ; et al. Phosphorylation-dependent sumoylation regulates estrogen-related receptor-alpha and -gamma transcriptional activity through a synergy control motif. MOLECULAR ENDOCRINOLOGY 22:570-584(2008).

Vila-Del Sol, V; Diaz-Munoz, MD; et al. Requirement of tumor necrosis factor at and nuclear factor-kappa B in the induction by IFN-gamma of inducible nitric oxide synthase in macrophages. JOURNAL OF LEUKOCYTE BIOLOGY 81:272-283(2007).