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Ngf

  • Official Full Name

    nerve growth factor (beta polypeptide)

  • Overview

    This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this genes expression is associated with allergic rhinitis. [provided by RefSeq, Jul 2008]
  • Synonyms

    NGF; nerve growth factor (beta polypeptide); NGFB; HSAN5; Beta-NGF; beta-nerve growth factor; nerve growth factor, beta subunit;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Transfected Stable Cell Lines
  • Native Proteins
  • GMP Proteins
  • Cattle
  • Chicken
  • Dog
  • Guinea pig
  • Horse
  • Human
  • Mouse
  • Pig
  • Rat
  • Rhesus monkey
  • Vulpes vulpes (Red fox)
  • Zebrafish
  • Bacillus subtilis
  • CHO
  • E. coli
  • E.coli
  • HEK293
  • HEK293F
  • HEK293T
  • Human
  • Human Cell
  • Human cells
  • Mammalian Cell
  • Mammalian cells
  • Mouse
  • Mouse Submaxillary Gland
  • Submaxillary gland
  • Submaxillary Gland of Grown Mouse
  • Yeast
  • C
  • Fc
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His(C
  • ter)
  • SUMO
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NGF-476H Active Recombinant Human Nerve Growth Factor (Beta Polypeptide) Mammalian Cell N/A
Human NGF-479H Active Recombinant Human NGF Mammalian cells N/A
Human NGF-14H Active Recombinant Human Nerve Growth Factor (Beta Polypeptide) HEK293 N/A
Human NGF-573H Active Recombinant Human Nerve Growth Factor (beta polypeptide) E.coli N/A
Human NGF-534H Active Recombinant Human NGF Human N/A
Human NGF-003H Active Recombinant Human NGF, HIgG1 Fc-tagged CHO Fc
Human NGF-001H Active Recombinant Human NGF, HIgG1 Fc-tagged, mutant CHO Fc
Human NGF-002H Active Recombinant Human NGF, MIgG2a Fc-tagged CHO Fc
Human NGF-1259H Acitve Recombinant Human NGF protein(Met1-Ala241) HEK293 N/A Met1-Ala241
Human NGF-05H Active Recombinant Human NGF protein CHO N/A Ser122-Arg239
Human NGF-1178H Recombinant Human Nerve Growth Factor (beta polypeptide) HEK293 N/A
Human NGF-11H Recombinant Human Pro-Nerve Growth Factor E.coli N/A
Human NGF-28H Recombinant Human Nerve Growth Factor (Beta Polypeptide) Mammalian cells N/A
Human NGF-537H Recombinant Human NGF protein, His-tagged E.coli His Glu19~Arg239
Human NGF-588H Recombinant Human NGF protein HEK293 N/A Ser122-Arg239
Human NGF-1287H Recombinant Human NGF, GST-tagged E.coli GST C-120aa
Human NGF-495H Recombinant Human NGF CHO N/A
Human NGF-1869H Recombinant Human Nerve Growth Factor (beta polypeptide) E.coli N/A
Human NGF-29918TH Recombinant Human NGF E.coli N/A 119 amino acids
Human NGF-54H Recombinant Human NGF Yeast N/A
Human NGF-29561TH Recombinant Human NGF N/A
Human NGF-425H Recombinant Human NGF protein, His-tagged HEK293F His Glu19~Arg239
Human NGF-001HCL Recombinant Human NGF cell lysate CHO N/A
Human NGF-814H Recombinant Human NGF Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human NGF-131H Active Recombinant Human NGF Protein E.coli
Human NGF-4655H Recombinant Human NGF Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human NGF-091H Active Recombinant Human NGF Protein E. coli
Human NGF-589H Active Recombinant Human NGF(Arg 121 Gly) protein HEK293 N/A Met1-Ala241
Human NGF-0302H Recombinant Human NGF protein E.coli N/A Glu19-Ala241
Human NGF-2488H Recombinant Human NGF Protein, His-tagged E.coli N-His Ser122-Ala241
Human NGF-257H Recombinant Active Human NGF Protein, His-tagged(C-ter) E.coli His(C-ter)
Human NGF-092H Active Recombinant Human NGF Protein E. coli
Human NGF-3158H Recombinant Human NGF Protein (Ser122-Ala241), His tagged E.coli His Ser122-Ala241
Human NGF-41H Active Recombinant Human NGF Protein, Animal Free Human cells
Human NGF-1508H Recombinant Human NGF Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human NGF-1508H-B Recombinant Human NGF Protein Pre-coupled Magnetic Beads HEK293
Human NGF-2511H Recombinant Human NGF protein(131-230 aa), N-SUMO & C-His-tagged E. coli N-SUMO & C-His 131-230 aa
Human NGF-124H Recombinant Human NGF Protein Human Cell Ser122-Arg239
Human NGF-0262H Recombinant Human NGF Protein (Ser122-Val238), Tag Free Bacillus subtilis Tag Free Ser122-Val238
Human NGF-4701H Recombinant Human NGF Protein (Met1-Val238), C-Fc tagged Mammalian cells C-Fc Met1-Val238
Human NGF-4702H Recombinant Human NGF Protein (Glu19-Ala241) E.coli Tag Free Glu19-Ala241
Human NGF-735HFL Recombinant Full Length Human NGF Protein, C-Flag-tagged Mammalian cells Flag
Human NGF-4703H Recombinant Human NGF Protein (Ser122-Val238), C-Fc tagged Mammalian cells C-Fc Ser122-Val238
Human NGF-128H Human Nerve Growth Factor(rDNA derived) Reference standard N/A
Human NGF-234H Active Recombinant Human NGF Protein (Ser122-Ala241), C-His tagged, Animal-free, Carrier-free E.coli C-His Ser122-Ala241
Human NGF-1314H Recombinant Human NGF Protein (Ser122-Arg239) Mammalian cells Tag Free Ser122-Arg239
Human NGF-213H Active Recombinant Human beta-NGF Protein E.coli
Human NGF-145H Recombinant Human NGF Protein E.coli Glu19-Ala241
Mouse Ngf-8330M Active Recombinant Mouse Ngf Mammalian cells N/A
Mouse Ngf-298M Active Native Mouse Nerve Growth Factor Mouse Submaxillary Gland N/A
Mouse Ngf-182M Active Native Mouse Ngf Protein Submaxillary Gland of Grown Mouse N/A
Mouse Ngf-01M Active GMP Recombinant Mouse Ngf Protein, His-Tagged E.coli His
Mouse Ngf-810M Active Recombinant Mouse Ngf protein E.coli N/A Met130-Arg239
Mouse Ngf-662M Recombinant Mouse Nerve Growth Factor Mouse N/A
Mouse Ngf-354M Recombinant Mouse Nerve Growth Factor Mammalian cells N/A
Mouse Ngf-09M Mouse Nerve Growth Factor, Liquid Submaxillary gland N/A
Mouse Ngf-477M Recombinant Mouse Ngf, None tagged CHO N/A
Mouse Ngf-10M Mouse Nerve Growth Factor, Lyophilized Submaxillary gland N/A
Mouse NGF-001MCL Recombinant Mouse NGF cell lysate CHO N/A
Mouse Ngf-71M Active Recombinant Mouse Ngf Protein (Ser122-Gly241), C-His tagged, Animal-free, Carrier-free E.coli C-His Ser122-Gly241
Mouse Ngf-51M Native Mouse Nerve Growth Factor 2.5S Mouse Submaxillary Gland N/A
Mouse Ngf-4406M Active Recombinant Mouse Ngf Protein E. coli
Mouse Ngf-5426M Recombinant Mouse Ngf Protein (Ser122-Ala241) E.coli Tag Free Ser122-Ala241
Mouse Ngf-10602M Recombinant Mouse Ngf Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Ngf-4407M Recombinant Mouse Ngf Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Ngf-10602M-B Recombinant Mouse Ngf Protein Pre-coupled Magnetic Beads HEK293
Mouse Ngf-1827M Recombinant Mouse Ngf Protein, His-tagged E.coli N-His Glu85-Gly307
Mouse NGF-214M Active Recombinant Mouse beta-NGF Protein E.coli
Mouse Ngf-1828M Recombinant Mouse Ngf Protein, His-tagged E.coli N-His Glu85-Gly307
Mouse Ngf-5427M Recombinant Mouse Ngf Protein (Met130-Arg239) E.coli Tag Free Met130-Arg239
Mouse Ngf-258M Recombinant Active Mouse NGF Protein, His-tagged(C-ter) E.coli His(C-ter)
Mouse NGF-3313M Recombinant Mouse NGF protein, His-GST-tagged E.coli His/GST Glu85~Gly307
Rat Ngf-5481R Recombinant Rat Ngf protein, His-tagged Yeast His 122-241aa
Rat Ngf-489R Recombinant Rat Ngf Protein(124-241aa), His-tagged E. coli N-His 124-241aa
Rat Ngf-1152R Recombinant Rat Ngf Protein, His-tagged HEK293F N-His Glu19-Gly241
Rat Ngf-1825R Recombinant Rat Ngf Protein, His-tagged E.coli N-His Glu19-Gly241 linked with LEHHHHHH
Rat Ngf-1826R Recombinant Rat Ngf Protein, His-tagged E.coli N-His Glu19-Gly241
Rhesus monkey NGF-1154R Recombinant Rhesus monkey NGF Protein, His-tagged E.coli N-His Glu19-Arg121+DDDDK+Ser122-Arg239
Dog NGF-0754D Recombinant Dog NGF Protein (Ser122-Gly238), C-Fc tagged E.coli C-Fc Ser122-Gly238
Cattle NGF-1157C Recombinant Cattle NGF Protein, His-tagged E.coli N-His Ser122-Ala241
Guinea pig Ngf-1158G Recombinant Guinea pig Ngf Protein, His-tagged E.coli N-His Glu19-Gly241
Horse NGF-1155H Recombinant Horse NGF Protein, His-tagged E.coli N-His Glu64-Ala286
Vulpes vulpes (Red fox) NGF-5607V Recombinant Red fox NGF Protein (Met1-Gly238), C-Fc tagged Mammalian cells C-Fc Met1-Gly238
Zebrafish NGF-9894Z Recombinant Zebrafish NGF Mammalian Cell His
Pig NGF-1153P Recombinant Pig NGF Protein, His-tagged E.coli N-His Ser110-Ala229
Pig NGF-4462P Recombinant Pig NGF protein, His-SUMO-tagged E.coli His-SUMO 110-229aa
Chicken NGF-5531C Recombinant Chicken NGF Mammalian Cell His
Chicken NGF-1156C Recombinant Chicken NGF Protein, His-tagged E.coli N-His Ala23-Pro243
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Ngf Related Articles
  • Ngf Related Gene Family
  • Ngf Related Research Area

Ngf involved in several pathways and played different roles in them. We selected most pathways Ngf participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ngf were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayATF4B1;RPS6KA4;RAC1A;MAP3K14;RPS6KA3A;MKNK1;TGFBR2;MAP2K5;RASGRP3
Ras signaling pathwayVEGFC;PLA2G12B;GNG13;HTR7;SHC2;INS1;CDC42;SHC4;Fgf15
Rap signaling pathwayFGFR4;LPAR5;VEGFB;FGF21;MAP2K1;MAPK12;HRAS;FGF1;NGF
PIK-Akt signaling pathwayITGA3;COL6A6;TEK;Kitl;RELA;FGF9;LAMB2;IFNA2;RBL2
ApoptosisHIST1H1A;STK24B;CASP7;IRAK3;CAPN1;TNFRSFA;CDK5RAP2;HIST1H1D;AKT2L
Neurotrophin signaling pathwayNTRK3;PIK3CB;MAPK9;NFKBIB;MAPK1;SHC1;GAB1;CAMK2D;KIDINS220
Inflammatory mediator regulation of TRP channelsKLK1B4;CYP2C39;PRKCH;IL1R1;PIK3CA;GNAS;TRPM8;CAMK2B;PIK3R5

Ngf has several biochemical functions, for example, growth factor activity, metalloendopeptidase inhibitor activity, nerve growth factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Ngf itself. We selected most functions Ngf had, and list some proteins which have the same functions with Ngf. You can find most of the proteins on our site.

Function Related Protein
growth factor activityFGF14;BMP8A;TDGF1;AMH;NOV;Fgf15;PDGFA;FGF1A;KLK1B4
metalloendopeptidase inhibitor activityTIMP1;TIMP2A;TIMP3;WFIKKN1;RECK;COL4A3;LXN;TIMP2;SPOCK1
nerve growth factor receptor bindingNTF7;NGF
protein bindingNFATC3;IL1R1;CD9;N6AMT1;BEX2;IFIT2;DLAT;SNRPE;DHX58
receptor signaling protein activityDOK2;ADRB1;IL4R;CD19;KLK1B3;TYROBP;PDCL;BAG4;TGFBR1

Ngf has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ngf here. Most of them are supplied by our site. Hope this information will be useful for your research of Ngf.

NTRK1; Ngfr; NGFR; SORT1; SORCS3

Gezginci-Oktayoglu, S; Karatug, A; et al. Nerve Growth Factor Neutralization Suppresses beta-Cell Proliferation Through Activin A and Betacellulin. PANCREAS 44:243-249(2015).
Paoletti, F; Malerba, F; et al. A comparative analysis of the structural, functional and biological differences between Mouse and Human Nerve Growth Factor. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS 1854:187-197(2015).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
Is there a role for NGF protein in pain? 12/06/2022

Studies have shown that NGF protein plays a role in the occurrence and development of pain. It stimulates the growth and survival of sensory neurons and enhances their ability to transmit signals, thereby increasing pain sensation. In addition, NGF can interact with other pain-related molecules to modulate pain perception and tolerance.

How to use the activity of NGF protein for disease treatment? 05/21/2022

There are a variety of drug development treatments that target NGF proteins and their related signaling pathways, including direct administration of NGF proteins, use of their analogues, or drugs that inhibit its degradation. These treatments are in clinical trials and are expected to provide new options for the treatment of neurological disorders.

How does the NGF protein interact with target cells? 04/13/2022

NGF proteins interact with target cells by binding to their receptors. It binds to TrkA receptors on the surface of target cells, triggering a series of signal transduction mechanisms that ultimately influence the biological behavior of target cells.

What is the role of NGF proteins in other systems? 05/22/2021

In addition to its important role in the nervous system, NGF proteins can also affect the function of other systems. For example, NGF proteins can affect the function of the immune system, involved in inflammatory responses and the development of autoimmune diseases.

Which function of NGF protein in glial cells? 01/20/2021

The function of NGF protein in glial cells is mainly to regulate its proliferation, differentiation and apoptosis. In addition, NGF promotes the repair and regeneration of damaged neurons by glial cells.

What are the biological activities of NGF proteins? 01/11/2019

NGF proteins have a variety of biological activities, including promoting neuronal growth, differentiation, survival, and repair of damage, regulating connections and signaling between neurons, and influencing the function of other systems.

Customer Reviews (3)

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Reviews
06/29/2022

    High catalytic efficiency, high safety and high expression level of the protein make it perform well in many experiments.

    08/06/2020

      The short half-life and high clearance of NGF make it possible to better control the concentration and action time of drugs in the body, so as to better control the therapeutic effect.

      08/27/2019

        This production process of NGF pays attention to the recycling of resources and minimizes waste, which is very consistent with the principle of green production.

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