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NHLRC1

  • Official Full Name

    NHL repeat containing 1

  • Overview

    The protein encoded by this gene is a single subunit E3 ubiquitin ligase. Laforin is polyubiquitinated by the encoded;protein. Defects in this intronless gene lead to an accumulation of laforin and onset of Lafora disease, also known as;progressive myoclonic epilepsy type 2 (EPM2).
  • Synonyms

    NHLRC1; NHL repeat containing 1; E3 ubiquitin-protein ligase NHLRC1; bA204B7.2; epilepsy; progressive myoclonus type 2B; EPM2B; malin; MGC119265; EPM2A; MGC119262; MGC119264; NHL repeat containing protein 1; NHL repeat-containing protein 1; NHLC1_HUMAN; NHLRC 1;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NHLRC1-1291H Recombinant Human NHLRC1, GST-tagged E.coli GST C-310aa
Human NHLRC1-30H Recombinant Human NHLRC1 Protein, GST-tagged Wheat Germ GST
Rat NHLRC1-3984R Recombinant Rat NHLRC1 Protein Mammalian Cell His
Rat NHLRC1-3643R Recombinant Rat NHLRC1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat NHLRC1-3643R-B Recombinant Rat NHLRC1 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • NHLRC1 Related Articles

NHLRC1 involved in several pathways and played different roles in them. We selected most pathways NHLRC1 participated on our site, such as Glucose metabolism, Glycogen synthesis, Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with NHLRC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Glucose metabolismSLC25A1A;AGL;GYG1B;PFKLB;EPM2A;SLC25A13;SLC25A11;GYG1A;SLC25A10
Glycogen synthesisGYG1B;NHLRC1;EPM2A;GYG1A
MetabolismCOQ6;SLC25A21;COX6C;NUDT4A;KIAA1199;CYP2AD3;NDUFAF5;NQO1;SLC4A1A
Metabolism of carbohydratesOXSR1;SLC35B2;B3GNT2A;CHST9;Gpc2;PYGMB;SLC25A1A;LYVE1;B3GAT2
Ubiquitin mediated proteolysisCDC34A;UBE4B;TCEB2;ANAPC13;WWP2;ANAPC11;UBR5;RNF7;FBXW11

NHLRC1 has several biochemical functions, for example, ligase activity, protein binding, ubiquitin protein ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NHLRC1 itself. We selected most functions NHLRC1 had, and list some proteins which have the same functions with NHLRC1. You can find most of the proteins on our site.

Function Related Protein
ligase activityUBR1;BRCA1;CTPS1A;UBE2D1A;MYLIP;MGRN1A;TRIM68;SH3RF2;TRIM2
protein bindingPTCH1;SNRNP70;SCN11A;NDC80;TRAF2;HLA-DOA;DNAI2;FOXK2;IDE
ubiquitin protein ligase activityCDK8;CDC42;TRIM72;MGRN1;RNF144B;PDZD4;RAG2;ANKIB1;RNF24
ubiquitin-protein transferase activityANKIB1A;FBXL14;TNFAIP3;UHRF1;TRIM68;FANCL;RNF135;TRIM13;HECTD3
zinc ion bindingRXRGA;CPO;ZCCHC2;RNF145B;ADH4;DTNA;NR1H4;ZDHHC8B;FHL3B

NHLRC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NHLRC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NHLRC1.

EPM2A; Epm2a; HSP90AB1

Smith, JA; Lovley, DR; et al. Outer Cell Surface Components Essential for Fe(III) Oxide Reduction by Geobacter metallireducens. APPLIED AND ENVIRONMENTAL MICROBIOLOGY 79:901-907(2013).
Brackmann, FA; Kiefer, A; et al. Rapidly Progressive Phenotype of Lafora Disease Associated With a Novel NHLRC1 Mutation. PEDIATRIC NEUROLOGY 44:475-477(2011).
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