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NKX2-1

Official Full Name

NK2 homeobox 1
Overview

NK2 homeobox 1 (NKX2-1), also known as thyroid transcription factor 1 (TTF-1), is a protein which in humans is encoded by the NKX2-1 gene. This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares the symbol/alias 'TFF1' with another gene, transcription termination factor 1, which plays a role in ribosomal gene transcription.
Synonyms

NKX2-1; NK2 homeobox 1; BCH, benign chorea , NKX2A, thyroid transcription factor 1 , TITF1; homeobox protein Nkx-2.1; TTF 1; TTF1; NK-2 homolog A; thyroid nuclear factor 1; thyroid transcription factor 1; homeobox protein NK-2 homolog A; BCH; BHC; NK-2;

Type

Recombinant Proteins

Species

Chicken
Human
Mouse

Source

E. coli
E.coli
In Vitro Cell Free System
Mammalian Cell
Protein Conjugation
Wheat Germ

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	NKX2-1-226H	Recombinant Human NK2 Homeobox 1	E.coli	N/A		Inquiry
Human	NKX2-1-3277H	Recombinant Human NKX2-1 protein, His&Myc-tagged	E.coli	His&Myc	1-371aa	Inquiry
Human	NKX2-1-02H	Recombinant Human NKX2-1 Protein, GST-tagged	Wheat Germ	GST	56-147	Inquiry
Human	NKX2-1-01H	Recombinant Human NKX2-1 Protein, GST-tagged	Wheat Germ	GST	1-371	Inquiry
Human	NKX2-1-5133H	Recombinant Human NKX2-1 Protein (Ala40-Pro111), N-GST tagged	E.coli	N-GST	Ala40-Pro111	Inquiry
Human	NKX2-1-384H	Recombinant Human NKX2-1 Protein, His&GST-tagged	E.coli	N-His&GST	Ala40-Pro111	Inquiry
Human	NKX2-1-6855HF	Recombinant Full Length Human NKX2-1 Protein, GST-tagged	In Vitro Cell Free System	GST	371 amino acids	Inquiry
Human	NKX2-1-2824H	Recombinant Human NKX2-1 Protein, His-tagged, OVA Conjugated	Protein Conjugation	N-His	Val13-Gly28	Inquiry
Mouse	NKX2-1-10697M	Recombinant Mouse NKX2-1 Protein, His-tagged	E. coli	His		$990 / 50ug
Chicken	NKX2-1-6184C	Recombinant Chicken NKX2-1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
NKX2-1 Related Articles

NKX2-1 involved in several pathways and played different roles in them. We selected most pathways NKX2-1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with NKX2-1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

NKX2-1 has several biochemical functions, for example, DNA binding, RNA polymerase II regulatory region DNA binding, RNA polymerase II regulatory region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NKX2-1 itself. We selected most functions NKX2-1 had, and list some proteins which have the same functions with NKX2-1. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	RAG1;NKX1.2LA;BARHL1B;THAP10;KCNIP3;HOXB1B;TFAP2B;AHRRA;ZNF653
RNA polymerase II regulatory region DNA binding	PPARG;NKX2-1;TXK;NCOA1;NPAS4;ATXN3L
RNA polymerase II regulatory region sequence-specific DNA binding	ALX1;RUNX3;BCL6A;ZNF812;ZNF583;NEUROD2;GFI1AA;MEF2A;BARHL1A
core promoter binding	NKX3-1;IFI203;CCAR1;MTF1;E2F2;SFPQ;MYBBP1A;TFAP2C;ARNTL
enzyme binding	PYCARD;GSTM4;FOXO4;HMOX1;TRAF2;GSTM3;THRB;BCL10;CYP2A4
intronic transcription regulatory region DNA binding	THRA;NKX2-1
intronic transcription regulatory region sequence-specific DNA binding	NKX2-1;GRHL2;BCL6
protein binding	DDX39A;FNDC3B;SEC61B;CHGB;NAPG;EGF;G3BP1;NAALADL2;CD14
sequence-specific DNA binding	DLX4A;HOXC5;ISL2B;DLX4;HESX1;HOXC4A;MEIS3;PTF1A;KDM6B
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	GATA5;RELA;USF2;ATF1;BHLHE40;SNAI2;SOX17;FOXC2;MEF2A
transcription factor activity, sequence-specific DNA binding	ZNF565;FOXK2;SMAD1;TCF7;ZNF317;FEV;ZKSCAN3;TADA3;CDX1A
transcription factor binding	UBN1;SMARCD3;GATA3;HEY1;NFATC3;FOXA2;RB1;BPTF;SMARCA4
transcription regulatory region DNA binding	TAL1;TBX16;HNRNPL;TAF9;TCF7L2;PAX8;ERBB4;GLIS2;ZNF821

NKX2-1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NKX2-1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NKX2-1.

Hmga2

Lindskog, C; Fagerberg, L; et al. The lung-specific proteome defined by integration of transcriptomics and antibody-based profiling. FASEB JOURNAL 28:5184-5196(2014).

DeMaio, L; Buckley, ST; et al. Ligand-independent transforming growth factor-ss type I receptor signalling mediates type I collagen-induced epithelial-mesenchymal transition. JOURNAL OF PATHOLOGY 226:633-644(2012).