NKX6-1
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Official Full Name
NK6 homeobox 1
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Overview
In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription;regulator that binds to AT-rich sequences within the promoter region of target genes Iype et al. (2004) (PubMed;15056733).
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- E. coli
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- His|GST
- N
- GST,C
- Involved Pathway
- Protein Function
- Interacting Protein
- NKX6-1 Related Articles
NKX6-1 involved in several pathways and played different roles in them. We selected most pathways NKX6-1 participated on our site, such as Maturity onset diabetes of the young, which may be useful for your reference. Also, other proteins which involved in the same pathway with NKX6-1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Maturity onset diabetes of the young | INS;FOXA3;NEUROG3;RFX6;IAPP;NKX6-1;HNF1A;NR5A2;HES1 |
NKX6-1 has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NKX6-1 itself. We selected most functions NKX6-1 had, and list some proteins which have the same functions with NKX6-1. You can find most of the proteins on our site.
Function | Related Protein |
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DNA binding | ZNF287;VOX;POLN;FOXG1;BLZF1;SP100;ZNF8;MEIOB;ENG1A |
RNA polymerase II core promoter proximal region sequence-specific DNA binding | NFIA;ARID3B;HOXA7;PPARA;PAXBP1;NKX6-2;ETV6;MYOD1;TFE3A |
chromatin binding | SOX15;SATB1;CENPA;PPARG;ZGLP1;SLC30A9;PLAC8;SFPQ;NSD1 |
sequence-specific DNA binding | DMRT3;PRRXL1;HMX3;SOX21A;FOXP4;NKX3;FLI1A;CUX2;RXRGB |
transcription factor activity, sequence-specific DNA binding | ARNTL1B;TWIST2;RHOXF1;MNX2A;POU2F1;RELA;HNF1B;SMAD6A;TBX22 |
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding | PRDM5;HMGA2;JDP2;CC2D1B;ZFPM2;KLF17;ZNF217;TBX3;HES1 |
NKX6-1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NKX6-1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NKX6-1.
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