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NLRP10

Official Full Name

NLR family, pyrin domain containing 10
Overview

Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). The protein encoded by this gene belongs to the NALP protein family despite lacking the LRR region. This protein likely plays a regulatory role in the innate immune system. The protein belongs to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. Other experiments indicate that this gene acts as a multifunctional negative regulator of inflammation and apoptosis.
Synonyms

NLRP10; NLR family, pyrin domain containing 10; NACHT, leucine rich repeat and PYD containing 10 , NALP10; NACHT, LRR and PYD domains-containing protein 10; CLR11.1; NOD8; nucleotide binding oligomerization domain; leucine rich repeat and pyrin domain con;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse

Source

E.coli
HEK293
HEK293T
Mammalian cells

Tag

Flag
GST
His
His (Fc)
Avi
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	NLRP10-3803HCL	Recombinant Human NLRP10 293 Cell Lysate	HEK293	N/A		Inquiry
Human	NLRP10-2866H	Recombinant Human NLRP10 protein, His-tagged	E.coli	His	1-180 aa	$319 / 25ug
Human	NLRP10-5638H	Recombinant Human NLRP10 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	NLRP10-3707H	Recombinant Human NLRP10 protein, GST-tagged	E.coli	GST	1-180 aa	$319 / 25ug
Human	NLRP10-1517H-B	Recombinant Human NLRP10 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Human	NLRP10-1119HFL	Recombinant Full Length Human NLRP10 Protein, C-Flag-tagged	Mammalian cells	Flag		Inquiry
Human	NLRP10-1517H	Recombinant Human NLRP10 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	Nlrp10-4434M	Recombinant Mouse Nlrp10 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry

Involved Pathway
Protein Function
Interacting Protein
NLRP10 Related Articles
NLRP10 Related Research Area

NLRP10 involved in several pathways and played different roles in them. We selected most pathways NLRP10 participated on our site, such as NOD pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NLRP10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
NOD pathway	NLRP10;NLRP4;NLRP2;PRDM1;NLRP7;SUGT1;COPS6;NLRP12;NLRP3

NLRP10 has several biochemical functions, for example, ATP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NLRP10 itself. We selected most functions NLRP10 had, and list some proteins which have the same functions with NLRP10. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	TRP53;TDRD9;CTPS2;MINK1;MAPK8B;ABCB6A;ADCK3;EIF2AK3;PKM

NLRP10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NLRP10 here. Most of them are supplied by our site. Hope this information will be useful for your research of NLRP10.

Krishnaswamy, JK; Singh, A; et al. Coincidental loss of DOCK8 function in NLRP10-deficient and C3H/HeJ mice results in defective dendritic cell migration. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112:3056-3061(2015).

Glorioso, N; Herrera, VL; et al. Sex-Specific Effects of NLRP6/AVR and ADM Loci on Susceptibility to Essential Hypertension in a Sardinian Population. PLOS ONE 8:-(2013).

Inflammasome