NME1
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Official Full Name
NME/NM23 nucleoside diphosphate kinase 1
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Overview
This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of A (encoded by this gene) and B (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Jul 2008] -
Synonyms
NME1; NME/NM23 nucleoside diphosphate kinase 1; NB; AWD; NBS; GAAD; NDKA; NM23; NDPKA; NDPK-A; NM23-H1; nucleoside diphosphate kinase A; NDP kinase A; granzyme A-activated DNase; metastasis inhibition factor nm23; tumor metastatic process-associated protein; non-metastatic cells 1, protein (NM23A) expressed in;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- NME1 Related Research Area
NME1 involved in several pathways and played different roles in them. We selected most pathways NME1 participated on our site, such as Purine metabolism, Pyrimidine metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with NME1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Purine metabolism | NME4;ENTPD2;POLR3GLB;RRM2B;AK7;IMPDH1;ADAL;POLR3K;PAICS |
| Pyrimidine metabolism | POLR2C;POLE4;CMPK2;ZNRD1;DPYDA.1;DPYD;DUT;NME3;ENTPD3 |
| Metabolic pathways | UGT1AB;GPT2L;IDO1;P4HA1B;PNP5A;NDUFB5;GNPDA1;PLA2G4F;HOGA1 |
NME1 has several biochemical functions, for example, ATP binding, GTP binding, deoxyribonuclease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NME1 itself. We selected most functions NME1 had, and list some proteins which have the same functions with NME1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | ATP1A1A.3;MAPK6;CAMKK1A;SHPK;AK7;CHUK;PANK1A;SMC2;PGK1 |
| GTP binding | HHAT;ARL8;RHOA;EEF1A1A;RAB42;RAB25A;TUBA4A;RAB39BA;RHOT1 |
| deoxyribonuclease activity | TATDN3;ENDOG;TATDN1;TATDN2;NME1;DNASE1L2;DNASE1L3L;DNASE1L1;DNASE1L3 |
| identical protein binding | PKD2;GBP1;NQO1;ACPP;DRD2;CSNK2B;ZNHIT6;AMOTL2;ORAI1 |
| magnesium ion binding | GEM;FOXK2;ENOSF1;PPM1NB;ATP10A;PRKACB;NUDT3;SRPK1;EPHX2 |
| nucleoside diphosphate kinase activity | TXNDC3;NME2B.2;NME3;AK1;AK8;NME2;AK4;NME5;CMPK1 |
| poly(A) RNA binding | NCBP1;YTHDF1;PDAP1;PRR3;ZFP326;MRPS15;HIST1H4A;NMD3;ZNFX1 |
| protein binding | CBX5;ZNF350;PMM2;FCER2;MRAP;CCKBR;CSNK1G1;ANK1;SAFB2 |
| ribosomal small subunit binding | NPM1;PIM1;PTCD3;NME1;DDX3X;DHX29;MTIF3;ERAL1;CPEB2 |
NME1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NME1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NME1.
N/A; POLR1C; NME4; NME3
- Q&As
- Reviews
Q&As (7)
Ask a questionNME1 plays a role in DNA repair, contributing to genomic stability.
NME1 modulates cellular responses to stress, affecting signal transduction pathways.
NME1 influences apoptosis and cell survival, impacting cell fate decisions.
Changes in NME1 can impact drug resistance in cancer, affecting treatment efficacy.
NME1 regulates the immune response, particularly in tumor immunity.
NME1 affects the metastatic behavior of cancer cells, influencing their spread.
NME1 is involved in nucleotide metabolism, crucial for maintaining cellular energy balance.
Customer Reviews (3)
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