nme6
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  • Official Full Name
  • non-metastatic cells 6, protein expressed in (nucleoside-diphosphate kinase)
  • Background
  • Nucleoside diphosphate (NDP) kinases (EC 2.7.4.6), such as NME6, are ubiquitous enzymes that catalyze transfer of;gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates;(Mehus et al., 1999 (PubMed 10453732)).
  • Synonyms
  • NME6; non-metastatic cells 6, protein expressed in (nucleoside-diphosphate kinase); nucleoside diphosphate kinase 6; IPIA ALPHA; NM23 H6; NDP kinase 6; inhibitor of p53-induced apoptosis-alpha; NDK 6; NM23-H6; IPIA-ALPHA
Cat.#:NME6-1315HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NME6, GST-tagged
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Cat.#:NME6-10743MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse NME6 Protein
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Cat.#:NME6-749CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus NME6 Protein, His-tagged
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Cat.#:NME6-9138ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish NME6
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Cat.#:NME6-3787HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human NME6 293 Cell Lysate
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Involved Pathway

NME6 involved in several pathways and played different roles in them. We selected most pathways NME6 participated on our site, such as Biosynthesis of antibiotics, CMP phosphorylation, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with NME6 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Biosynthesis of antibiotics
ADH5; ECHS1; pykF; GALM; DAO; UAP1L1; DLAT; LDHAL6B; NME6; SDS
CMP phosphorylation
CMPK2; NME6
Metabolic pathways
P4HA1; UGT2B7; THA1; ASAH2; PGAM2; PI4KAA; GGT5; AOX2P; B4GALT3; ACSL3
Purine metabolism
AMPD2; IMPDH1B; UOX; GUCY2F; ADK; POLR1B; IMPDH1A; POLR2J2; CANT1B; ENTPD8
Pyrimidine metabolism
POLR1D; POLE; POLR3E; ENTPD8; CTPS2; NT5M; UCK2B; NME4; DPYD; NT5C2B
UTP and CTP de novo biosynthesis
CMPK2; NME6
adenosine deoxyribonucleotides de novo biosynthesis
NME6
guanosine deoxyribonucleotides de novo biosynthesis
NME6

Protein Function

NME6 has several biochemical functions, for example, ATP binding, metal ion binding, nucleoside diphosphate kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NME6 itself. We selected most functions NME6 had, and list some proteins which have the same functions with NME6. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein SGK1; DHX38; MAP4K3; TAE1; TTN; NSFB; PRKD2; RECQL4; PAPOLB; STK25
Function metal ion binding
Related Protein CYCS; ADO; ZNF512; CPEB1B; E4F1; ZFP598; ZDHHC16A; SCRT1B; C6AST1; ZDHHC16
Function nucleoside diphosphate kinase activity
Related Protein AK7; AK5; NME3; AK8; NME7; AK9; CMPK1; NME2B.2; AK4; NME8

Interacting Protein

NME6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NME6 here. Most of them are supplied by our site. Hope this information will be useful for your research of NME6.
SSSCA1; WBSCR16

NME6 Related Articles

Haglund, S; Almer, S; et al. Gene Expression and Thiopurine Metabolite Profiling in Inflammatory Bowel Disease - Novel Clues to Drug Targets and Disease Mechanisms?. PLOS ONE 8:-(2013).
Wang, CH; Ma, NH; et al. A shRNA Functional Screen Reveals Nme6 and Nme7 Are Crucial for Embryonic Stem Cell Renewal. STEM CELLS 30:2199-2211(2012).