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NMNAT2

  • Official Full Name

    nicotinamide nucleotide adenylyltransferase 2

  • Overview

    This gene product belongs to the nicotinamide mononucleotide adenylyltransferase (NMNAT) enzyme family, members of which catalyze an essential step in NAD (NADP) biosynthetic pathway. Unlike the other human family member, which is localized to the nucleus, and is ubiquitously expressed; this enzyme is cytoplasmic, and is predominantly expressed in the brain. Two transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    NMNAT2; nicotinamide nucleotide adenylyltransferase 2; C1orf15, chromosome 1 open reading frame 15; nicotinamide mononucleotide adenylyltransferase 2; KIAA0479; PNAT2; C1orf15; MGC2756; NaMN adenylyltransferase 2; Nicotinate-nucleotide adenylyltransferase 2; NMN adenylyltransferase 2; NMNA2_HUMAN; NMNAT 2; PNAT 2; Pyridine nucleotide adenylyltransferase 2; OTTHUMP00000033548; OTTHUMP00000033549;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NMNAT2-251H Recombinant Human NMNAT2, His tagged Insect Cell His
Human NMNAT2-300H Recombinant Human nicotinamide nucleotide adenylyltransferase 2, His-tagged E.coli His
Human NMNAT2-28747TH Recombinant Human NMNAT2, His-tagged E.coli His 306 amino acids
Human NMNAT2-638H Recombinant Human NMNAT2, His-tagged E.coli His
Human NMNAT2-001HCL Recombinant Human NMNAT2 cell lysate Insect Cell N/A
Human NMNAT2-1165H Recombinant Human NMNAT2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human NMNAT2-5467H Recombinant Human NMNAT2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human NMNAT2-5939H Recombinant Human NMNAT2 Protein, GST-tagged Wheat Germ GST
Human NMNAT2-6595HF Recombinant Full Length Human NMNAT2 Protein, GST-tagged In Vitro Cell Free System GST 302 amino acids
Mouse Nmnat2-4444M Recombinant Mouse Nmnat2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat NMNAT2-4006R Recombinant Rat NMNAT2 Protein Mammalian Cell His
Rat NMNAT2-3665R Recombinant Rat NMNAT2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat NMNAT2-3665R-B Recombinant Rat NMNAT2 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish NMNAT2-10365Z Recombinant Zebrafish NMNAT2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

NMNAT2 involved in several pathways and played different roles in them. We selected most pathways NMNAT2 participated on our site, such as Nicotinate and nicotinamide metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with NMNAT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Nicotinate and nicotinamide metabolismNMNAT1;NMNAT2;NUDT12;NMNAT3;AOX3L1;PNP;AOX4;MIBP;NMRK2
Metabolic pathwaysGGT5;MGAT5;MVD;CBR2;IPMKB;SPRA;ATP5O;ATP5IB;HSD3B4

NMNAT2 has several biochemical functions, for example, ATP binding, nicotinamide-nucleotide adenylyltransferase activity, nicotinate-nucleotide adenylyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NMNAT2 itself. We selected most functions NMNAT2 had, and list some proteins which have the same functions with NMNAT2. You can find most of the proteins on our site.

Function Related Protein
ATP bindingCCT8L2;FYNB;GARS;GSK3AA;SGK3;ABCB6;CLCN5;ACSM3;ACSM4
nicotinamide-nucleotide adenylyltransferase activityNMNAT3;NMNAT1;NMNAT2
nicotinate-nucleotide adenylyltransferase activityNMNAT3;ABL1;NMNAT2;NMNAT1

NMNAT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NMNAT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NMNAT2.

  • Q&As
  • Reviews

Q&As (5)

Ask a question
How does NMNAT2 relate to other proteins involved in neuroprotection? 09/13/2022

NMNAT2 is part of a network of proteins involved in neuroprotection, and understanding these interactions may provide insights into potential therapeutic strategies.

Are there any ongoing clinical trials related to NMNAT2? 11/17/2020

It's essential to check the latest clinical trial databases for updated information, as ongoing trials may be exploring the therapeutic potential of NMNAT2.

Are there any specific neurodegenerative diseases linked to NMNAT2 dysfunction? 09/19/2017

Some studies suggest a connection between NMNAT2 and conditions like Alzheimer's disease, making it a potential target for therapeutic interventions.

How can the clinical application of NMNAT2 impact aging? 10/03/2016

As NMNAT2 is associated with NAD+ production, its clinical application may have implications for addressing age-related decline in cellular function and overall health.

Can dietary interventions impact NMNAT2 levels? 01/02/2016

Some studies suggest that certain dietary interventions, such as those affecting NAD+ levels, may indirectly influence NMNAT2 activity.

Customer Reviews (3)

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Reviews
04/17/2019

    It reliably and accurately detects and quantifies target molecules, allowing for precise measurement of analytes in my samples.

    11/25/2018

      The NMNAT2 Protein consistently produces well-defined and interpretable structural data, enabling me to unravel complex macromolecular assemblies and their mechanisms.

      01/28/2017

        The sensitivity and specificity of the NMNAT2 Protein have consistently delivered robust and consistent results, enhancing the efficiency and accuracy of my experimental workflows.

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