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NMT1

  • Official Full Name

    N-myristoyltransferase 1

  • Overview

    Myristate, a rare 14-carbon saturated fatty acid, is cotranslationally attached by an amide linkage to the N-terminal glycine residue of cellular and viral proteins with diverse functions. N-myristoyltransferase (NMT; EC 2.3.1.97) catalyzes the transfer of myristate from CoA to proteins. N-myristoylation appears to be irreversible and is required for full expression of the biologic activities of several N-myristoylated proteins, including the alpha subunit of the signal-transducing guanine nucleotide-binding protein (G protein) GO (GNAO1; MIM 139311) (Duronio et al., 1992
  • Synonyms

    NMT1; N-myristoyltransferase 1; glycylpeptide N-tetradecanoyltransferase 1; alternative; short form NMT S; long form; NMT L; myristoyl CoA:protein N myristoyltransferase; NMT; NMT 1; long form, NMT-L; alternative, short form NMT-S; type I N-myristoyltrans;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NMT1-3783HCL Recombinant Human NMT1 293 Cell Lysate HEK293 N/A
Human NMT1-1355HFL Recombinant Full Length Human NMT1 Protein, C-Flag-tagged Mammalian cells Flag
Human NMT1-6602HF Recombinant Full Length Human NMT1 Protein, GST-tagged In Vitro Cell Free System GST 496 amino acids
Human NMT1-1521H Recombinant Human NMT1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human NMT1-5945H Recombinant Human NMT1 Protein, GST-tagged Wheat Germ GST
Human NMT1-1521H-B Recombinant Human NMT1 Protein Pre-coupled Magnetic Beads HEK293
Mouse NMT1-10754M Recombinant Mouse NMT1 Protein Mammalian Cell His
Mouse Nmt1-4447M Recombinant Mouse Nmt1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse NMT1-6120M Recombinant Mouse NMT1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse NMT1-6120M-B Recombinant Mouse NMT1 Protein Pre-coupled Magnetic Beads HEK293
Rat NMT1-4009R Recombinant Rat NMT1 Protein Mammalian Cell His
Rat NMT1-3668R Recombinant Rat NMT1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat NMT1-3668R-B Recombinant Rat NMT1 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • NMT1 Related Articles

NMT1 involved in several pathways and played different roles in them. We selected most pathways NMT1 participated on our site, such as Activation, myristolyation of BID and translocation to mitochondria, Apoptosis, Disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with NMT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Activation, myristolyation of BID and translocation to mitochondriaNMT1;Gzmg;GZME;GZMF;GZMC
ApoptosisIKBKB;MAP3K14;STK24A;BAXB;HIST1H1D;CYCS;PPP3CC;CASP8L1;DIABLOB
DiseaseCUX1;SFTPB;IPO5;OGN;NMT2;TRAT1;NA;TLR6;KERA
HIV InfectionPPIAL4A;CDK9;VPS37A;NMT2;DOCK2;TCEB3;AP1M2;PSIP1;PSTPIP2
HIV Life CyclePSIP1;PDCD6IP;VPS37A;PSTPIP2;CHMP4B;TAF1L;NMT2;SSRP1;CHMP4C
Inactivation, recovery and regulation of the phototransduction cascadeMETAP2B;PPEF1;NMT1B;RGS9BP;NMT2;GUCA1E;NMT1;METAP1;RHOL
Infectious diseaseCHMP4C;RCC1;CCDC167;IPO5;APOBEC3G;PDCD6IP;ANTXR1;NMT2;EEF2
Intrinsic Pathway for ApoptosisBAXB;NMT1;GZMC;GZMF;Gzmg;DIABLOB;GZME;DIABLOA;DIABLO

NMT1 has several biochemical functions, for example, glycylpeptide N-tetradecanoyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NMT1 itself. We selected most functions NMT1 had, and list some proteins which have the same functions with NMT1. You can find most of the proteins on our site.

Function Related Protein
glycylpeptide N-tetradecanoyltransferase activityNMT1B;NMT2;NMT1;NMT1A

NMT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NMT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NMT1.

nef; TP53; CAPN2; ssrna_ug; NOP56; VIM; Eif3a; Rpl35; Rrbp1; Ccdc77; Wdr61

Rampoldi, F; Sandhoff, R; et al. A new, robust, and nonradioactive approach for exploring N-myristoylation. JOURNAL OF LIPID RESEARCH 53:2459-2468(2012).
Tamm, T; et al. Plasmids with E2 epitope tags: tagging modules for N- and C-terminal PCR-based gene targeting in both budding and fission yeast, and inducible expression vectors for fission yeast. YEAST 26:55-66(2009).
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