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NMU

Official Full Name

Neuromedin U
Overview

Neuromedin U (NmU) is a vertebrate peptide which stimulates uterine smooth muscle contraction and causes selective vasoconstriction. Like most other active peptides, it is proteolytically processed from a larger precursor protein. The mature peptides are 8 (NmU-8) to 25 (NmU-25) residues long and C-terminally amidated. The sequence of the C-terminal extremity of NmU is extremely well conserved across species.
Synonyms

NmU; Neuromedin U; Neuromedin U 25; NmU 25;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Rat

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
His|GST
His|T7
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	NMU-741H	Recombinant Human NMU	Mammalian Cell	His		Inquiry
Human	NMU-5751H	Recombinant Human NMU protein, His & GST-tagged	E.coli	His/GST	Ala35~Ile158 (Accession # P48645)	Inquiry
Human	NMU-34H	Recombinant Human NMU, His-tagged	HEK293	His		Inquiry
Human	NMU-3781HCL	Recombinant Human NMU 293 Cell Lysate	HEK293	N/A		Inquiry
Human	NMU-6604HF	Recombinant Full Length Human NMU Protein, GST-tagged	In Vitro Cell Free System	GST	36-174 amino acids	Inquiry
Human	NMU-5946H	Recombinant Human NMU Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	NMU-3940H	Recombinant Human NMU Protein (Ala35-Ile174), N-GST tagged	E.coli	N-GST	Ala35-Ile174	Inquiry
Human	NMU-3645H-B	Recombinant Human NMU Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Human	NMU-3645H	Recombinant Human NMU Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	NMU-4010R	Recombinant Rat NMU Protein	Mammalian Cell	His		Inquiry
Rat	Nmu-5752R	Recombinant Rat Nmu protein, His & T7-tagged	E.coli	His/T7	Cys38~Ile174 (Accession # P12760)	Inquiry
Rat	NMU-3669R-B	Recombinant Rat NMU Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	NMU-3669R	Recombinant Rat NMU Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Chicken	NMU-5253C	Recombinant Chicken NMU	Mammalian Cell	His		Inquiry
Chicken	NMU-5254C	Recombinant Chicken NMU	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
NMU Related Articles

NMU involved in several pathways and played different roles in them. We selected most pathways NMU participated on our site, such as Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events, G alpha (q) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with NMU were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Class A/1 (Rhodopsin-like receptors)	LTB4R;OPN1SW1;INSL5;ANXA1;PENKA;GPR17;ZFPM2B;GPR37B;GPR55A
G alpha (i) signalling events	GPR17;PMCH;FPR-RS3;CXCL11.8;CNR2;TAS2R13;SSTR4;SSTR3;ADRA2A
G alpha (q) signalling events	FPR-RS3;ANXA1A;LPAR5A;CHRM3;OPN4B;NMBB;TAC1;NPS;KISS1
GPCR downstream signaling	AGTR2;ADCYAP1R1;PNOCB;ARHGEF16;CASR;TRPC7;CYSLTR1;RGS1;FGD2
GPCR ligand binding	GPR37B;SSTR1;PTH2;RGS1;INSL3;LPAR1;OPN4B;RLN3A;S1PR1
Gastrin-CREB signalling pathway via PKC and MAPK	ANXA1A;DGKQ;NPFFR2;MGLL;UTS2D;UTS2;EDN3;GPR4;LPAR1
Peptide ligand-binding receptors	PRLH;NPS;NMS;PENKB;UTS2;AMCF-II;PPY;FPR-RS6;TAC2
Signal Transduction	SH2B3;PROKR2;ARHGEF16;RDH14A;SHRPRBCK1R;ASH2L;KAL1;ARHGAP29B;PYGO1

NMU has several biochemical functions, for example, neuromedin U receptor binding, protein binding, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NMU itself. We selected most functions NMU had, and list some proteins which have the same functions with NMU. You can find most of the proteins on our site.

Function	Related Protein
neuromedin U receptor binding
protein binding	SRI;IFI35;FAM65B;AICDA;CETN2;CDC20B;LPAL2;EFNA4;Aatk
receptor binding	WNT4A;SRC;CD200;MAG;CCL15;APOL2;DIAPH1;PAOX;TNFSF4

NMU has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NMU here. Most of them are supplied by our site. Hope this information will be useful for your research of NMU.

KRTAP5-9; NOTCH2NL; TNS2

Rani, S; Corcoran, C; et al. Neuromedin U: A Candidate Biomarker and Therapeutic Target to Predict and Overcome Resistance to HER-Tyrosine Kinase Inhibitors. CANCER RESEARCH 74:3821-3833(2014).

Zhang, YM; Jiang, DS; et al. Neuromedin U Type 1 Receptor Stimulation of A-type K+ Current Requires the beta gamma Subunits of G(o) Protein, Protein Kinase A, and Extracellular Signal-regulated Kinase 1/2 (ERK1/2) in Sensory Neurons. JOURNAL OF BIOLOGICAL CHEMISTRY 287:18562-18572(2012).