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NNT

  • Official Full Name

    nicotinamide nucleotide transhydrogenase

  • Overview

    This gene encodes an integral protein of the inner mitochondrial membrane. The enzyme couples hydride transfer between NAD(H) and NADP(+) to proton translocation across the inner mitochondrial membrane. Under most physiological conditions, the enzyme uses energy from the mitochondrial proton gradient to produce high concentrations of NADPH. The resulting NADPH is used for biosynthesis and in free radical detoxification. Two alternatively spliced variants, encoding the same protein, have been found for this gene.
  • Synonyms

    NNT; nicotinamide nucleotide transhydrogenase; NAD(P) transhydrogenase, mitochondrial; mitochondrial; MS701; NAD(P) transhydrogenase; NAD(P) transhydrogenase mitochondrial; NNTM; NNTM_HUMAN; Pyridine nucleotide transhydrogenase; OTTHUMP00000122432; OTTHUMP00000122433; OTTHUMP00000221608;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Human
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NNT-1321H Recombinant Human NNT, GST-tagged E.coli GST 1-207aa
Human NNT-3778HCL Recombinant Human NNT 293 Cell Lysate HEK293 N/A
Human NNT-3777HCL Recombinant Human NNT 293 Cell Lysate HEK293 N/A
Human NNT-5957H Recombinant Human NNT Protein, GST-tagged Wheat Germ GST
Human NNT-6672HF Recombinant Full Length Human NNT Protein, GST-tagged In Vitro Cell Free System GST 207 amino acids
Zebrafish NNT-12777Z Recombinant Zebrafish NNT Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

NNT involved in several pathways and played different roles in them. We selected most pathways NNT participated on our site, such as Nicotinate and nicotinamide metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with NNT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Nicotinate and nicotinamide metabolismNT5C2A;AOX1;AOX3;NADKA;NAPRT1;PNP;NMNAT2;NADSYN1;NNT
Metabolic pathwaysNDUFA4;CYP2B19;GALK1;ATP6V1BA;GOT2A;POLR3C;NAPRT1;SMPD5;GKUP

NNT has several biochemical functions, for example, NAD binding, NAD(P)+ transhydrogenase (AB-specific) activity, NAD(P)+ transhydrogenase (B-specific) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NNT itself. We selected most functions NNT had, and list some proteins which have the same functions with NNT. You can find most of the proteins on our site.

Function Related Protein
NAD bindingPHGDH;GPD1;MDH1;AHCY;LDHA;HSD3B4;LDHB;IDH3B;ME3
NAD(P)+ transhydrogenase (AB-specific) activity
NAD(P)+ transhydrogenase (B-specific) activity
NAD(P)+ transhydrogenase activityDHDH;NNT
NADP bindingMTRR;FMO5;H6PD;SPR;G6PDX;CRYZL1;POR;IDH1;DPYD

NNT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NNT here. Most of them are supplied by our site. Hope this information will be useful for your research of NNT.

MVP; PAPD5; Wiz; Mkln1; MME; Junb; Papss1; HUWE1; ATL2; NEIL3; Cdc26; Mis12; SLAIN2

  • Q&As
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