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NODAL

  • Official Full Name

    nodal growth differentiation factor

  • Overview

    The protein encoded by this gene is a member of the TGF-beta superfamily. Studies of the mouse counterpart suggested that this gene may be essential for mesoderm formation and subsequent organization of axial structures in early embryonic development. [provided by RefSeq, Jul 2008]
  • Synonyms

    NODAL; nodal growth differentiation factor; HTX5; nodal homolog;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NODAL-30H Recombinant Human Nodal E.coli N/A
Human NODAL-30448TH Recombinant Human NODAL Wheat Germ N/A 72 amino acids
Human NODAL-528H Recombinant Human NODAL Mammalian Cell His
Human NODAL-3771HCL Recombinant Human NODAL 293 Cell Lysate HEK293 N/A
Human NODAL-5964H Recombinant Human NODAL Protein, GST-tagged Wheat Germ GST
Human NODAL-3648H Recombinant Human NODAL Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human NODAL-2494H Recombinant Human NODAL Protein, His-tagged E.coli N-His Ala27-Leu347
Human NODAL-6680HF Recombinant Full Length Human NODAL Protein, GST-tagged In Vitro Cell Free System GST 326 amino acids
Human NODAL-2913H Recombinant Human NODAL protein, His-tagged E.coli His 40-338 aa
Human NODAL-0528H Recombinant Human NODAL protein, GST-tagged E.coli GST His238-Leu347
Human NODAL-3648H-B Recombinant Human NODAL Protein Pre-coupled Magnetic Beads HEK293
Human NODAL-235H Active Recombinant Human NODAL Protein (His238-Leu347), C-His tagged, Animal-free, Carrier-free E.coli C-His His238-Leu347
Mouse NODAL-28M Recombinant Mouse Nodal E.coli N/A
Mouse NODAL-0527M Recombinant Mouse NODAL protein, GST-tagged E.coli GST His245-Leu354
Mouse NODAL-29M Recombinant Mouse NODAL Protein, His-tagged E.coli His His245~Leu354
Mouse Nodal-1833M Recombinant Mouse Nodal Protein, His-tagged E.coli N-His His245-Leu354
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • NODAL Related Articles
  • NODAL Related Research Area

NODAL involved in several pathways and played different roles in them. We selected most pathways NODAL participated on our site, such as TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with NODAL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
TGF-beta signaling pathwayBMPR2;BAMBIA;BMPR1AB;BMP8A;TGFB2;ID1;NODAL;LEFTY2;RBL1
Signaling pathways regulating pluripotency of stem cellsAKT1;WNT6;PIK3CG;JARID2;WNT9A;ACVR2B;FZD6;SOX2;LIF

NODAL has several biochemical functions, for example, cytokine activity, growth factor activity, morphogen activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NODAL itself. We selected most functions NODAL had, and list some proteins which have the same functions with NODAL. You can find most of the proteins on our site.

Function Related Protein
cytokine activityBMP4;FASLG;IL1F10;TNFSF8;IL17A/F3;BMP7;CLCF1;IL19;SECTM1
growth factor activityIL5;FGF6B;FGF1B;FGF12A;BMP8B;FGF16;FGF18B;GDF11;OSM
morphogen activityShh;CER1;DAND5;GREM1;NBL1;NODAL
receptor agonist activitySFRP2;WNT4;VEGFA;WNT2;GREM1;WNT1;WNT7A;NODAL;CXCL13
transforming growth factor beta receptor bindingGDF11;INHBA;INHA;GDF2;GDF6B;BMP5;BMP15;TGFB1A;MSTNA
type I activin receptor bindingSPAW;SMAD6;NDR1;NDR2;NODAL

NODAL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NODAL here. Most of them are supplied by our site. Hope this information will be useful for your research of NODAL.

Cardona, C; Sanchez-Mejias, E; et al. Expression of Gls and Gls2 Glutaminase Isoforms in Astrocytes. GLIA 63:365-382(2015).
Rutgen, BC; Gerner, W; et al. Exploratory assessment of CD4(+) T lymphocytes in brown hares (Lepus europeus) using a cross-reactive anti-rabbit CD4 antibody. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY 161:108-115(2014).
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