NOS2
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Official Full Name
nitric oxide synthase 2, inducible
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Overview
Nitric oxide synthase, inducible is an enzyme that in humans is encoded by the NOS2 gene. Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. Alternative splicing of this gene results in two transcript variants encoding different isoforms. -
Synonyms
NOS2; nitric oxide synthase 2, inducible; HEP-NOS; NOS; nitric oxide synthase 2A (inducible, hepatocytes); Hepatocyte NOS; Inducible NO synthase; Peptidyl-cysteine S-nitrosylase NOS2; NOS type II; EC 1.14.13.39; INOS; nitric oxide synthase, inducible; nitric oxide synthase, macrophage; NOS, type II; inducible NOS; OTTHUMP00000163279; NOS2A;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- E. coli
- E.coli
- HEK293
- HEK293T
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- His|T7
- Myc
- DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- NOS2 Related Articles
- NOS2 Related Research Area
NOS2 involved in several pathways and played different roles in them. We selected most pathways NOS2 participated on our site, such as Arginine biosynthesis, Arginine and proline metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with NOS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Arginine biosynthesis | CPS1;ybaS;ASL;ACY1;GOT2;GOT2A;ARG1;GLS;NOS2A |
| Arginine and proline metabolism | AMD1;CARNS1;P4HA1A;ALDH3A2A;PRODH2;CKMA;DAO.3;ARG2;NOS2A |
| Metabolic pathways | ME1;PTDSS2;ADSL;SMPD5;XDH;FPGT;ATP6V0E2;DCT;GSS |
| Calcium signaling pathway | ORAI1;CACNA1D;TACR3L;ADCY1B;CALML5;MYLK2;P2RX4;PRKACBB;PHKG2 |
| HIF- signaling pathway | AKT2;TCEB2;TFRC;IFNGR1;PDHA1;MAPK3;PGK1;ALDOA;CAMK2G |
| Peroxisome | PEX16;NOS2A;PEX11C;GNPAT;HMGCLL1;DAO.2;PEX5L;SCP2;MPV17L |
| Salmonella infection | DYNC1LI1;ACTB1;NOS2A;PYCARD;CXCL3;IFNG1-2;TLR4;ARPC5LB;WASLA |
| Pertussis | IL12A;NLRP3;CXCL5;NOS2;C1R;C1RA;MAPK10;CASP1;MAPK8 |
| Leishmaniasis | TGFB1;MARCKSL1;PRKCB;TNF;CR1;IL12B;NFKB1;MAP3K7;HLA-DRB4 |
| Chagas disease (American trypanosomiasis) | CCL3L3;C3;PIK3CD;C1QC;GNA11;GNAL;CD3E; CD3D;PPP2R2C;C1QA |
| Toxoplasmosis | AKT2;IRAK1;LDLR;IL12B;Toxoplasma Gondii Microneme Protein MIC3;TGFB1;BCL2;BIRC7;TNFRSF1A |
| Amoebiasis | IL6;IL12A;COL24A1;LAMA1;RAB7;ACTN1;TLR2;TNF;CTSG |
| Tuberculosis | CARD9;NFYB;IFNA10;FCGR2C;CALML5;SPHK1;NFYC;TNFRSF1A;HLA-DMB |
| Pathways in cancer | RARB;PIAS2;GNA12;PDGFRA;ETS1;MAP2K2;RARA;AGTR1B;F2RL3 |
| Small cell lung cancer | ITGAV;SKP2;PIK3CD;PTK2;TRAF6;RB1;TRAF5;LAMA3;TRAF4 |
NOS2 has several biochemical functions, for example, FMN binding, NADP binding, NADPH-hemoprotein reductase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NOS2 itself. We selected most functions NOS2 had, and list some proteins which have the same functions with NOS2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| FMN binding | TYW1;HAO1;PNPO;CREG2;NOS2A;NDOR1;POR;NOS1;MTRR |
| NADP binding | G6PD;DHFRL1;PGD;CRYZL1;FMO3;NNT;MTHFR;SPR;FMO2 |
| NADPH-hemoprotein reductase activity | MTRR;POR;NOS2;NOS3;CYP2J6;NOS1;NDOR1;NOS2A;NOS2B |
| arginine binding | NOS3;RARS;NOS2;NAGS;NOS1 |
| calmodulin binding | CNN1;CAMK1GA;OBSCN;MYH13;MYO1F;PHKA1;PCDP1;PDE1A;CNGA2 |
| flavin adenine dinucleotide binding | AOX3L1;ETFA;NOS1;ACADS;SQLEA;D2HGDH;DMGDH;IVD;ACOXL |
| heme binding | HBB-BH1;CYP2K19;NOS2;HBQ1;CYP2J2;CYP4V7;CYP19A1B;NGB;CYP27A1 |
| iron ion binding | ALOX5A;PHF8;HBBE2;CYP2D26;FAM84B;FAM125B;CYP2Y3;HBBE3;CYP46A1.4 |
| nitric-oxide synthase activity | NOS2;NOS1;NOS3;NOS2A;NOS2B |
| protein binding | CD163;USP20;SEC63;SLC30A1;PGM2;MGP;PTGES2;LRRC47;U2AF1 |
| protein homodimerization activity | CER1;SLC30A8;EIF2AK1;IGJ;GPD1C;BHLHB9;HNF1A;G6PDX;PRTFDC1 |
| receptor binding | PTPRD;CCL17;CADM1B;SRMS;HAND2;Ar;BMP3;MCHR1;WIPI1 |
| tetrahydrobiopterin binding | NOS2;NOS1;TH;NOS3 |
NOS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NOS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NOS2.
GAPDH; S100A8; S100A9; arginine
- Q&As
- Reviews
Q&As (5)
Ask a questionGenetic polymorphisms in the NOS2 gene have been associated with susceptibility to certain diseases and can influence individual response to treatment.
Certain inflammatory markers and nitric oxide levels can be associated with NOS2 protein expression in clinical settings.
NOS2 protein plays a role in the host defense against pathogens by generating nitric oxide to inhibit microbial growth.
Monitoring changes in NOS2 protein expression may provide insights into treatment response and help evaluate therapeutic efficacy in clinical trials.
Customer Reviews (3)
Write a reviewThey can provide technical assistance, ensuring optimal utilization of the product.
This unique capability to selectively bind to exposed PS simplifies the identification and quantification of different cellular populations, reducing experimental errors and enhancing accuracy.
This may include providing detailed protocols, troubleshooting guidance, and access to knowledgeable experts who can answer any inquiries or concerns.
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