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NOS3

  • Official Full Name

    nitric oxide synthase 3

  • Overview

    Endothelial NOS (eNOS), also known as nitric oxide synthase 3 (NOS3) or constitutive NOS (cNOS), is an enzyme that in humans is encoded by the NOS3 gene. Endothelial NOS is a nitric oxide synthase that generates NO in blood vessels and is involved with regulating vascular tone by inhibiting smooth muscle contraction and platelet aggregation. A constitutive Ca2+ dependent NOS provides a basal release of NO. eNOS is associated with plasma membranes surrounding cells and the membranes of Golgi bodies within cells.
  • Synonyms

    NOS3; Nitric oxide synthase 3 (endothelial cell); eNOS; ECNOS; Constitutive NOS; Endothelial NOS; EC-NOS; NOSIII; cNOS; NOS type III; EC 1.14.13.39; nitric oxide synthase, endothelial; OTTHUMP00000213183; OTTHUMP00000212826; OTTHUMP00000213184; OTTHUMP00000213185;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bovine
  • Cattle
  • Dog
  • Human
  • Mouse
  • Pig
  • Rat
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NOS3-7856H Recombinant Human NOS3 protein, His-tagged E.coli His Arg756~Gln888 (Accession # P29474)
Human NOS3-635H Recombinant Human Nitric Oxide Synthase 3 (Endothelial Cell) Sf9 Insect Cell N/A
Human NOS3-28567TH Recombinant Human NOS3 Wheat Germ N/A 100 amino acids
Human NOS3-1206HCL Recombinant Human NOS3 cell lysate N/A
Human NOS3-6567H Recombinant Human NOS3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human NOS3-157HFL Recombinant Full Length Human NOS3 Protein, C-Flag-tagged Mammalian cells Flag
Human NOS3-5993H Recombinant Human NOS3 Protein, GST-tagged Wheat Germ GST
Human NOS3-1156H Recombinant Human NOS3 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human NOS3-1526H Recombinant Human NOS3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human NOS3-4717H Recombinant Human NOS3 Protein (Met1-Lys192), N-His tagged E.coli N-His Met1-Lys192
Human NOS3-1526H-B Recombinant Human NOS3 Protein Pre-coupled Magnetic Beads HEK293
Mouse NOS3-10787M Recombinant Mouse NOS3 Protein Mammalian Cell His
Mouse Nos3-7857M Recombinant Mouse Nos3 protein, His-tagged E.coli His Glu888~Pro1001 (Accession # P70313)
Mouse Nos3-1836M Recombinant Mouse Nos3 Protein, His&GST-tagged E.coli N-His&GST Arg97-Lys485
Mouse Nos3-4462M Recombinant Mouse Nos3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse NOS3-6138M-B Recombinant Mouse NOS3 Protein Pre-coupled Magnetic Beads HEK293
Mouse NOS3-6138M Recombinant Mouse NOS3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Nos3-7860R Recombinant Rat Nos3 protein, His-tagged E.coli His Ala519~Phe702 (Accession # Q62600)
Rat NOS3-4025R Recombinant Rat NOS3 Protein Mammalian Cell His
Rat NOS3-3684R-B Recombinant Rat NOS3 Protein Pre-coupled Magnetic Beads HEK293
Rat NOS3-3684R Recombinant Rat NOS3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Nos3-5300R Recombinant Rat Nos3 protein, His-tagged E.coli His 519-690aa
Dog NOS3-7855D Recombinant Dog NOS3 protein, His & T7-tagged E.coli His/T7 Ala522~Phe705 (Accession # Q9TUX8)
Bovine NOS3-66B Recombinant bovine NOS3 Protein, His-tagged Insect Cell
Bovine NOS3-003B Recombinant Bovine NOS3 Protein E. coli 2-1205
Cattle NOS3-7854C Recombinant Cattle NOS3 protein, His & T7-tagged E.coli His/T7 Ala522~Phe705 (Accession # P29473)
Pig NOS3-7858P Recombinant Pig NOS3 protein, His-tagged E.coli His Ala522~Phe705 (Accession # Q28969)
Pig NOS3-7859P Recombinant Pig NOS3 protein, His-tagged E.coli His Arg758~Pro1004 (Accession # Q28969)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • NOS3 Related Articles

NOS3 involved in several pathways and played different roles in them. We selected most pathways NOS3 participated on our site, such as Arginine biosynthesis, Arginine and proline metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with NOS3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Arginine biosynthesisGPT2;ybaS;GLUD1;GOT2A;NOS1;NOS2;NOS2A;GLUL;GLUD1A
Arginine and proline metabolismDAO.2;ALDH7A1;CKBB;DAO;NOS2B;OAT;ODC1;SAT1A.1;ABP1
Metabolic pathwaysNANS;TPO;SUCLG2;CMBL;PLA2G4AA;HSD3B2;SCLY;IMPAD1;HSD17B12
Calcium signaling pathwayDRD7;PLCD1A;PPP3CCA;GNA15;PPP3CB;PRKACAA;GNA11;PRKACBA;CACNA1SA
cGMP-PKG signaling pathwayVDAC3;PIK3CD;ATP1A1;VDAC1;NFATC3;SLC25A6;PIK3R1;PRKG1;ITPR1
HIF- signaling pathwayEPO;PIK3CB;INS2;NOS2;CAMK2A;RPS6KB1;CUL2;RELA;PIK3CA
Sphingolipid signaling pathwayNRAS;PPP2R2D;AKT2;ABCC1;ROCK2;RAF1;S1PR5;PPP2R2B;DEGS1
PIK-Akt signaling pathwayTLR2;MET;SPP1;GHR;OSMR;G6PC3;PDPK1;RPS6KB1;ANGPT4
VEGF signaling pathwayPLCG2;RAC1B;PRKCBA;PTK2AA;RAC3A;SHC2;MAPK14B;MAP2K1;CDC42L2
Platelet activationFCGR2A;MYLK4;ORAI1;COL27A1;GP1BB;FYN;PRKG2;FGB;NOS3
Estrogen signaling pathwayAKT1;CALML5;MAPK3;GRM1;GNAS;KCNJ5;CALM2;PRKCD;KCNJ3
Oxytocin signaling pathwayEEF2K;PIK3R3;RGS2;CAMK2B;PLA2G4C;PLA2G4F;PPP3CC;MYL6B;CACNG1
Insulin resistanceG6PC;PTPN11;TBC1D4;PRKAA2;CREB3L3L;CREB3L2;FOXO1;MLXIPL;PIK3R3B

NOS3 has several biochemical functions, for example, FMN binding, NADP binding, NADPH-hemoprotein reductase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NOS3 itself. We selected most functions NOS3 had, and list some proteins which have the same functions with NOS3. You can find most of the proteins on our site.

Function Related Protein
FMN bindingTYW1B;MTRR;CREG2;DHODH;NOS3;HAO2;NOS1;NDOR1;POR
NADP bindingHMGCRA;G6PD;DHFRL1;FMO2;HMGCRB;SPR;GSR;H6PD;NNT
NADPH-hemoprotein reductase activityNOS2A;NOS3;NOS1;NDOR1;POR;NOS2;NOS2B;CYP2J6;MTRR
actin monomer bindingCOBL;PKNOX2;ABL2;MYL4;TMSB;KLHL8;NOS3;PFN2;PFN4
arginine bindingNOS1;NOS2;NAGS;RARS;NOS3
cadmium ion bindingMT3;NOS3;SLC11A2;NOS1;P2RX2
calmodulin bindingADCY3;CAMSAP1;PDE1C;GAP43;SNTB2;KCNN3;KCNQ3;STRN;CAMK1G
flavin adenine dinucleotide bindingDPYD;AIFM4;AOX4;CYB5R3;ACAD11;TXNRD3;XDH;MTO1;POR
heme bindingCYB5A;CYP2E1;MPO;CYP2K16;HBB;NR1D1;CYP26C1;CYP4V7;CYP4A11
iron ion bindingCYP8B3;P4HTM;CYP8B2;CYP1A;PDF;CYP17A1;AOX4;CYP4F2;CYP2P9
nitric-oxide synthase activityNOS2B;NOS3;NOS1;NOS2A;NOS2
protein bindingC19orf60;TFIP11;ZNF2;FADD;CXCL10;PLEKHM1;GTF3C5;SHMT1;GP1BB
scaffold protein bindingNLGN3;ADCY6;KCNQ1;KRT18;PANX1;NCK2;KRT15;CIT;VIM
tetrahydrobiopterin bindingNOS1;NOS3;TH;NOS2

NOS3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NOS3 here. Most of them are supplied by our site. Hope this information will be useful for your research of NOS3.

NOSTRIN; AKT1; CDC37; tax; MAGEA11

Piccoli, JCE; Manfredini, V; et al. Association between endothelial nitric oxide synthase gene polymorphism (-786T > C) and interleukin-6 in acute coronary syndrome. HUMAN & EXPERIMENTAL TOXICOLOGY 33:396-402(2014).
Syeda, F; Hauton, D; et al. How ubiquitous is endothelial NOS?. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY 166:207-214(2013).
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