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Notch1

  • Official Full Name

    notch 1

  • Overview

    This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development. [provided by RefSeq, Jul 2008]
  • Synonyms

    NOTCH1; notch 1; hN1; TAN1; neurogenic locus notch homolog protein 1; Notch homolog 1, translocation-associated; translocation-associated notch protein TAN-1;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Cell & Tissue Lysates
  • Chicken
  • Human
  • Mouse
  • Rat
  • CHO
  • E. coli
  • E.coli
  • HEK293
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Fc
  • Fc Chimera
  • GST
  • HIgG1 Fc
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NOTCH1-384H Active Recombinant Human NOTCH1 protein, Fc-tagged Mammalian cells Fc
Human NOTCH1-0569H Active Recombinant Human NOTCH1 protein, Fc-tagged HEK293 Fc Ala19-Gln526
Human NOTCH1-385H Recombinant Human NOTCH1 protein, His-tagged HEK293 His Ala19-Gln526
Human NOTCH1-29727TH Recombinant Human NOTCH1 Wheat Germ N/A 110 amino acids
Human NOTCH1-5996H Recombinant Human NOTCH1 Protein, GST-tagged Wheat Germ GST
Human NOTCH1-127H Recombinant Human NOTCH1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human NOTCH1-531HB Recombinant Human NOTCH1 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Ala19-Gln526
Human NOTCH1-461H Recombinant Human NOTCH1 Protein (Ala19-Gln526), HIgG1 Fc-tagged HEK293 HIgG1 Fc Ala19-Gln526
Human NOTCH1-2498H Recombinant Human NOTCH1 Protein, His-tagged E.coli N-His Glu1949-Tyr2209
Human NOTCH1-127H-B Recombinant Human NOTCH1 Protein Pre-coupled Magnetic Beads HEK293
Human NOTCH1-531H Recombinant Human NOTCH1 protein, His-Avi-tagged HEK293 His-Avi Ala19-Gln526
Mouse Notch1-400M Active Recombinant Mouse Notch1, Fc Chimera CHO Fc Chimera
Mouse NOTCH1-884M Active Recombinant Mouse NOTCH1 Protein, His-tagged Insect Cell His
Mouse Notch1-422M Active Recombinant Mouse Notch1 protein, His-tagged Insect Cell His Met 1-Gln 526
Mouse NOTCH1-0570M Active Recombinant Mouse NOTCH1 protein, His-tagged HEK293 His Ala19-Gln526
Mouse Notch1-435M Recombinant Mouse Notch1, Fc-tagged CHO Fc
Mouse Notch1-423M Recombinant Mouse Notch1 protein, Fc-tagged CHO Fc Met1-Gln526
Mouse NOTCH1-469MCL Recombinant Mouse NOTCH1 cell lysate Insect Cell N/A
Mouse Notch1-420M Recombinant Mouse Notch1 protein, GST-tagged E. coli GST 1924-2209 aa
Mouse Notch1-1837M Recombinant Mouse Notch1 Protein, His-tagged E.coli N-His Glu1919-Ile2079
Rat Notch1-2540R Recombinant Rat Notch1, Fc Chimera Mammalian cells Fc
Rat Notch1-13R-B Recombinant Rat Notch1 Protein Pre-coupled Magnetic Beads HEK293
Rat Notch1-13R Recombinant Rat Notch1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken NOTCH1-2220C Recombinant Chicken NOTCH1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Notch1 Related Articles
  • Notch1 Related Research Area
  • Notch1 Related Signal Pathway

Notch1 involved in several pathways and played different roles in them. We selected most pathways Notch1 participated on our site, such as Dorso-ventral axis formation, Notch signaling pathway, Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Notch1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Dorso-ventral axis formationNOTCH1B;CPEB3;ETV6;ETV7;KRAS;CPEB1B;CPEB1A;GRB2;CPEB1
Notch signaling pathwayRBPJB;HER6;ADAM12;SNW1;NOTCH4;NUMBL;JAG1A;HES1;MFAP2
Thyroid hormone signaling pathwayMAPK1;ATP1A2;TP53;AKT1;HDAC3;ACTG1;MAPK3;RXRB;MED27
Prion diseasesC1QC;NOTCH1;NCAM2;HSPA1A;PRKACA;IL6;C8A;IL1B;PRKACG
MicroRNAs in cancerIRS2;WNT3;PTEN;IGF2BP1;MCL1;DNMT3A;RECK;HRAS;WNT3A

Notch1 has several biochemical functions, for example, Notch binding, calcium ion binding, chromatin DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Notch1 itself. We selected most functions Notch1 had, and list some proteins which have the same functions with Notch1. You can find most of the proteins on our site.

Function Related Protein
Notch bindingJAG1A;NCOR2;JAG2B;C8orf4;DTX1;DLL3;DNER;ADAM17;GALNT11
calcium ion bindingGAS6;PCDHB1;NOTCH2;S100A2;CABP1B;CAPN12;RAB11FIP4;C2CD4A;PCDH1G31
chromatin DNA bindingH2AFY;SMAD3;EZH2;ZIC2;GRHL1;HIST1H1E;INSM1A;AASS;RARA
core promoter bindingINSM1B;GATA1;RBMX;HMGA2;MED1;INSM1A;NONO;SFPQ;E2F8
enzyme bindingCAT;CABYR;ZNF346;HMOX1;ARRB2;MAPT;CYP3A4;HIST1H2AM;CNTNAP2
enzyme inhibitor activityANGPTL4;TXNIP;NOTCH1;ATPIF1A;CALU;ATPIF1B;PLN;PDE6H;APOV1
protein bindingINIP;PYYA;GPSM3;TLR4;BAHD1;FBXL8;SLC2A4;USH2A;SAP30BP
protein heterodimerization activityCHUK;HIST1H2BB;PIK3R2;NEUROD2;HIST1H4C;GABRR1;TAF11;MAP3K7;SEPHS1
receptor activityP2RY1;VMN1R41;UNC13B;NLGN4X;KLRG1;GRIN2BB;TNFRSF10B;EDA2R;MED14
sequence-specific DNA bindingHEY2;ATF7A;HOXA9B;HOXB7;UNCX4.1;HOXB6;HOXC9A;DMBX1B;NKX2.1
transcription factor activity, sequence-specific DNA bindingMNT;MYCN;TBR1;NKX3;AFF4;ZSCAN12;NR5A2;ZNF691;GABPB1
transcriptional activator activity, RNA polymerase II transcription factor bindingCREB1;KLF14;PPARA;NKX2-5;NOTCH1;CLOCK;GBX2;SOX10;LMO2

Notch1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Notch1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Notch1.

RBPJ; XIAP; PIN1; SNW1

Irshad, K; Mohapatra, SK; et al. A Combined Gene Signature of Hypoxia and Notch Pathway in Human Glioblastoma and Its Prognostic Relevance. PLOS ONE 10:-(2015).
Huntzicker, EG; Hotzel, K; et al. Differential Effects of Targeting Notch Receptors in a Mouse Model of Liver Cancer. HEPATOLOGY 61:942-952(2015).
  • Q&As
  • Reviews

Q&As (7)

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How does NOTCH1 contribute to the regulation of embryonic development and tissue homeostasis? 09/22/2022

NOTCH1 contributes to the regulation of embryonic development and tissue homeostasis by influencing cell differentiation and proliferation.

What are the ligands or interacting partners of NOTCH1, and how do they regulate its activation? 09/22/2021

The ligands or interacting partners of NOTCH1 include Delta-like 1 (DLL1), Delta-like 3 (DLL3), Delta-like 4 (DLL4), Jagged 1, and Jagged 2, regulating its activation.

What is the primary function of Neurogenic locus notch homolog protein 1 (NOTCH1) in cellular processes and signaling? 06/02/2021

Neurogenic locus notch homolog protein 1 (NOTCH1) functions in cellular processes, primarily playing a role in the Notch signaling pathway.

What diseases or conditions are associated with dysregulation or abnormal expression of NOTCH1? 05/12/2021

Dysregulation or abnormal expression of NOTCH1 is associated with conditions such as cancer, cardiovascular diseases, and developmental disorders.

In which cellular compartments is NOTCH1 predominantly localized? 02/24/2018

NOTCH1 is predominantly localized on the cell membrane, where it undergoes proteolytic cleavage upon activation.

Are there therapeutic implications or potential targets related to NOTCH1 in diseases involving Notch signaling? 07/09/2017

There are potential therapeutic implications related to NOTCH1 in diseases involving Notch signaling, making it a target for drug development.

How does NOTCH1 participate in the Notch signaling pathway, and what is its role in cell fate determination? 09/12/2016

NOTCH1 participates in the Notch signaling pathway by interacting with ligands such as Delta and Jagged, influencing cell fate determination.

Customer Reviews (3)

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Reviews
01/24/2021

    Continuous access to up-to-date training materials ensured that our team remained well-versed in the product's capabilities.

    05/09/2017

      The product's evolution in response to user feedback showcased a dedication to meeting the evolving needs of researchers.

      11/04/2016

        The product's compatibility with open science practices positively influenced our decision to adopt it for our experiments.

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