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NOTCH3

Official Full Name

notch 3
Overview

This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq, Jul 2008]
Synonyms

NOTCH3; notch 3; IMF2; CASIL; CADASIL; neurogenic locus notch homolog protein 3; Notch homolog 3;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat
Zebrafish

Source

E.coli
HEK293
Insect Cell
Mammalian Cell
Sf21 Insect Cell
Wheat Germ

Tag

Fc
GST
hFc
His
His (Fc)
Avi
His|GST
TRxA
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	NOTCH3-948H	Active Recombinant Human NOTCH3 protein, His-tagged	HEK293	His	Ala1378-Ser1640	Inquiry
Human	NOTCH3-0545H	Active Recombinant Human NOTCH3 protein, Fc-tagged	HEK293	Fc	Ala40-Glu467	Inquiry
Human	NOTCH3-2543H	Recombinant Human Notch Homolog 3 (Drosophila), Fc Chimera	Sf21 Insect Cell	Fc		Inquiry
Human	NOTCH3-29729TH	Recombinant Human NOTCH3	Wheat Germ	N/A	110 amino acids	Inquiry
Human	NOTCH3-1813H	Recombinant Human NOTCH3 protein, His & GST-tagged	E.coli	His/GST	Leu2053~Gln2318 (Accession # Q9UM47)	Inquiry
Human	NOTCH3-047H	Recombinant Human NOTCH3 protein, hFc-tagged	HEK293	hFc	Ala40-Glu467	Inquiry
Human	NOTCH3-5999H	Recombinant Human NOTCH3 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	NOTCH3-947H	Recombinant Human NOTCH3 protein, His-Avi-tagged	HEK293	His-Avi	Ala40-Glu467	Inquiry
Human	NOTCH3-1814H	Recombinant Human NOTCH3 protein, His-TRxA-tagged	E.coli	His-TRxA	Leu2053~Gln2318	Inquiry
Human	NOTCH3-947HB	Recombinant Human NOTCH3 protein, His-Avi-tagged, Biotinylated	HEK293	His-Avi	Ala40-Glu467	Inquiry
Human	NOTCH3-4721H	Recombinant Human NOTCH3 Protein (Ala40-Glu467), N-His tagged	E.coli	N-His	Ala40-Glu467	Inquiry
Mouse	Notch3-2544M	Recombinant Mouse Notch Gene Homolog 3 (Drosophila) , Fc Chimera	Insect Cell	Fc		Inquiry
Mouse	Notch3-1839M	Recombinant Mouse Notch3 Protein, His&GST-tagged	E.coli	N-His&GST	Ala40-Thr273	Inquiry
Rat	NOTCH3-4028R	Recombinant Rat NOTCH3 Protein	Mammalian Cell	His		Inquiry
Rat	NOTCH3-3687R	Recombinant Rat NOTCH3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	NOTCH3-3687R-B	Recombinant Rat NOTCH3 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	NOTCH3-9094Z	Recombinant Zebrafish NOTCH3	Mammalian Cell	His		Inquiry

NOTCH3 involved in several pathways and played different roles in them. We selected most pathways NOTCH3 participated on our site, such as Dorso-ventral axis formation, Notch signaling pathway, Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NOTCH3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Dorso-ventral axis formation	ETV7;SPIRE1;CPEB2;GRB2;CPEB3;CPEB1B;SPIRE2;GRB2B;ETV6
Notch signaling pathway	DLA;NUMBL;MARK2;APH1C;DTX3;DTX2;HER15.1;MFNG;PSEN2
Thyroid hormone signaling pathway	MTOR;GATA4;AKT1;HDAC1;SLC2A1;GSK3B;MED13L;NOTCH3;FXYD2
MicroRNAs in cancer	FOXP1;TIMP3;PTEN;IRS1;MDM2;NOTCH3;DNMT3B;KRAS;ROCK1

NOTCH3 has several biochemical functions, for example, calcium ion binding, enzyme binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NOTCH3 itself. We selected most functions NOTCH3 had, and list some proteins which have the same functions with NOTCH3. You can find most of the proteins on our site.

Function	Related Protein
calcium ion binding	ANXA11B;ITPR3;CHP1;S100A10A;SPARC;FREM1A;EFHD2;PCDHA9;CELSR3
enzyme binding	N4BP2L2;RCOR2;UGT1A4;PPP3CA;USF1;CYP2A4;CPSF1;HSPA1A;PRKCH
protein binding	HIST1H1A;MAPK4;SHD;DIS3L;PBK;RNF138;SNAPC3;GTF2A1L;TTC17

NOTCH3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NOTCH3 here. Most of them are supplied by our site. Hope this information will be useful for your research of NOTCH3.

Psma1; ABL1; NCK1; JAG1; LRP1; ANKRD28; FBLN1; CSNK2B; opuD; ald1; q8d176_yerpe; rhsA5; E2F3

Huntzicker, EG; Hotzel, K; et al. Differential Effects of Targeting Notch Receptors in a Mouse Model of Liver Cancer. HEPATOLOGY 61:942-952(2015).

Minuzzo, S; Agnusdei, V; et al. DLL4 regulates NOTCH signaling and growth of T acute lymphoblastic leukemia cells in NOD/SCID mice. CARCINOGENESIS 36:115-121(2015).

Glioma Biomarkers

EMT Induction

Notch Family