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NOX1

  • Official Full Name

    NADPH oxidase 1

  • Overview

    Voltage-gated proton (hydrogen) channels play an important role in cellular defense against acidic stress. They are unique among ion channels with respect to their extremely high selectivity, marked temperature dependence, and unitary conductance, which is 3 orders of magnitude lower than that of most other ion channels. NOX1 is a homolog of the catalytic subunit of the superoxide-generating NADPH oxidase of phagocytes, gp91phox. Two transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    NOX1; NADPH oxidase 1; GP91 2; mitogenic oxidase (pyridine nucleotide dependent superoxide generating); MOX1; NADPH oxidase 1 variant NOH 1L; NADPH oxidase homolog 1; NOH 1; NOH1; MOX-1; NOX-1; mitogenic oxidase 1; NADPH oxidase homolog-1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • In vitro E. coli expression system
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • His|T7
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NOX1-1335H Recombinant Human NOX1, His-tagged E.coli His 292-560aa
Human NOX1-1359H Recombinant Human NOX1 protein, His-tagged E.coli His Met235~Asn488
Human NOX1-404H Recombinant Human NOX1 Mammalian Cell His
Human NOX1-3751HCL Recombinant Human NOX1 293 Cell Lysate HEK293 N/A
Human NOX1-3659H Recombinant Human NOX1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human NOX1-1329H Recombinant Human NOX1 Full Length Transmembrane protein, His-tagged In vitro E. coli expression system His 1-564aa
Human NOX1-3659H-B Recombinant Human NOX1 Protein Pre-coupled Magnetic Beads HEK293
Human NOX1-4191H Recombinant Human NOX1 Protein (Arg54-Glu283), N-His tagged E.coli N-His Arg54-Glu283
Mouse NOX1-10797M Recombinant Mouse NOX1 Protein Mammalian Cell His
Mouse NOX1-6146M Recombinant Mouse NOX1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse NOX1-6146M-B Recombinant Mouse NOX1 Protein Pre-coupled Magnetic Beads HEK293
Rat NOX1-4030R Recombinant Rat NOX1 Protein Mammalian Cell His
Rat Nox1-2796R Recombinant Rat Nox1 protein, His & T7-tagged E.coli His/T7 Arg291~Arg544 (Accession # Q9WV87)
Rat NOX1-3689R Recombinant Rat NOX1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat NOX1-3689R-B Recombinant Rat NOX1 Protein Pre-coupled Magnetic Beads HEK293
Homo sapiens (Human) RFL13066HF Recombinant Full Length Human Nadph Oxidase 1(Nox1) Protein, His-Tagged E.coli expression system His Full Length (1-564aa)
Mus musculus (Mouse) RFL32513MF Recombinant Full Length Mouse Nadph Oxidase 1(Nox1) Protein, His-Tagged E.coli expression system His Full Length (1-591)
Rattus norvegicus (Rat) RFL7282RF Recombinant Full Length Rat Nadph Oxidase 1(Nox1) Protein, His-Tagged E.coli expression system His Full Length (1-563)
Zebrafish NOX1-5913Z Recombinant Zebrafish NOX1 Mammalian Cell His
Chicken NOX1-3741C Recombinant Chicken NOX1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • NOX1 Related Articles

NOX1 involved in several pathways and played different roles in them. We selected most pathways NOX1 participated on our site, such as HIF- signaling pathway, Phagosome, Osteoclast differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with NOX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
HIF- signaling pathwayPRKCG;Trf;INSR;PDK1;BCL2;IGF1R;CAMK2G;RELA;Il6ra
PhagosomeATP6V1C1A;SFTPA1;C3A.2;ATP6V0A1B;H2-Q10;ATP6V1E1B;TUBAL3;THBS4B;BLB1
Osteoclast differentiationTRAF6;SFPI1;TNFRSF11A;LILRA4;TGFBR2;TYROBP;FCGR4;IFNGR2;GRB2
Leukocyte transendothelial migrationMAPK11;RAP1B;OCLN;MYL12B;CLDN6;CLDN11;ITGAM;CLDN14;VAV3

NOX1 has several biochemical functions, for example, NADP binding, Rac GTPase binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NOX1 itself. We selected most functions NOX1 had, and list some proteins which have the same functions with NOX1. You can find most of the proteins on our site.

Function Related Protein
NADP bindingGAPDHS;GSR;ASPDH;NNT;HMGCRB;CRYM;FMO5;FMO2;G6PD
Rac GTPase bindingDVL1;SRGAP2A;SRGAP1;PKN1;PAK7;CDKL5;RAB7;CAV1;PAK3
metal ion bindingSAP30L;GTPBP8;ZNF485;ZNF800;ZNF776;CD209;SEC23IP;ZFP426;TET3
protein bindingATP4B;KCNA3;TNS4;ELK1;Apba1;TET3;CYBRD1;DOHH;ASMTL
superoxide-generating NADPH oxidase activityNOX3;NCF1;NOX1;NOX4;PAX2;CYBB;NOX5;SH3PXD2AA
voltage-gated proton channel activityNOX1;HVCN1

NOX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NOX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NOX1.

Matsumoto, M; Katsuyama, M; et al. Characterization of N-glycosylation sites on the extracellular domain of NOX1/NADPH oxidase. FREE RADICAL BIOLOGY AND MEDICINE 68:196-204(2014).
Ren, RD; Azuma, Y; et al. Modulation of platelet aggregation-related eicosanoid production by dietary F-fucoidan from brown alga Laminaria japonica in human subjects. BRITISH JOURNAL OF NUTRITION 110:880-890(2013).
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